0021-972x/92/7405-1215$03.00/0 Journal of Clinical Endocrinology and Metabolism Copyright 0 1992 by The Endocrine Society
Vol. 74, No. 5 Printed
Report on the Nomenclature TABLE
of the IGF Binding
in U.S. A.
Proteins
1. Terminology of the newly discovered IGFBPs Proposed designation hIGFBP-4 hIGFBP-5
hIGFBP-6
a In the publication IGFBP-4. -
Source TESS osteosarcoma Human (rat) serum Human osteoearcoma cell-line Cerebro-spinal fluid Human Bone extract Human (rat) serum Cerebro-spinal fluid Transformed and fetal fibroblaste Human (rat) serum
of Kiefer et al. (Refs. 5 and 7) IGFBP-5 has been temporarily
Participants San Francisco
of the Second International IGF Symposium in interested in the characterization and nomenclature of the insulin-like growth factor binding proteins (IGFBPs) met on Wednesday January 16,199l. It was felt that
the nomenclatureproposaladoptedduring the workshopon the IGF Binding Proteins held in Vancouver in June 1989served its purposeand had found generalacceptanceamongthe investigators around the world involved in IGF and IGFBP research. During the last 2 yr, three more IGFBPs have been discovered and their amino acid sequencedetermined, thus increasing the total number of IGFBPs thus far fully characterized to six. The following is the consensusdevelopedat the San Francisco meeting on the terminology of the newly discovered IGFBPs. In order to avoid confusion in the literature a recommendation was made at this meeting for all researchersin the field to adhereto the proposeddesignation(Table 1). Finally, in order to avoid confusion in the future it was unanimously agreed to request all investigators intending to further enlargethe IGFBP family to report the finding of any new memberof the IGFBP family to Dr. Stenvert L. S. Drop in order to assureproper nomenclature assignment.The minimal requirement would be a significantly different N-terminal or cDNA sequence. Participants of the SecondInternational IGF Symposium.F. J. Ballard, Ph.D., Division of Human Nutrition, CSIRO, Adelaide, Australia; R. C. Baxter, Ph.D., Department of Endocrinology, Royal Prince Alfred Hospital, Camperdown,New South Wales, Australia; M. Binoux, M.D., INSERM U 142, Saint-Antoine, Paris, France; D. R. Clemmons,M.D., Department of Internal Medicine, University of North Carolina, Chapel Hill, North ReceivedOctober7,199l. Address all correspondence and requesta for reprints to: Dr. Stenvert L. S. Drop, P.O. Box 70029.3000 LL Rotterdam, The Netherlands.
N-terminal amino acid sequence DEAIHCPPCSEEKLA
1-5”
LGSFVHCEPCDEKAL
6, 7”-10
ALARCPGCGQGVQAG
5”,11-15
Ref.
designated IGFBP-6, whereas IGFBPB
hae been termed
Carolina; S.L. S. Drop, M.D., Department of Pediatrics,Sophia Children’s Hospital, Erasmus University, Rotterdam, The Netherlands, K. Hall, M.D., Department of Endocrinology, Karolinska Institutet, Stockholm, Sweden;R. L. Hintz, M.D., Department of Pediatrics, Stanford University, Stanford, California; N. Ling, Ph.D., Department of Molecular Endocrinology, The Whittier Institute for Diabetes and Endocrinology, LaJolla, California; S. Mohan, Ph.D., Department of Med. Biochemistry and Physiology, Loma Linda University, Loma Linda, California; M. M. Rechler, M.D., Growth and Development Section,
MCNEB,
NIDDK,
NIH,
Bethesda,
Maryland;
E. M. Rutanen, M.D., Dept. II of Obstetrics and Gynecology, Helsinki, Finland, University Central Hospital, SF-99290,Helsinki, Finland; J. C. Schwander,M.D., Department of Internal Medicine, University of Basal,Switzerland; E. Martin Spencer, M.D., Ph.D., Laboratory of Growth and Development, Children’s Hospital, San Francisco, California; and J. Zapf, M.D. Metabolic Unit, Department of Medicine, University Hospital, Zurich, Switzerland.
References 1. Mohan S, Bautista C, Wergedal J, Baylink DJ 1989 Isolation of an inhibitory insulin-like growth factor (IGF) binding protein from bone cell conditioned medium: a potential local regulator of IGF action. Proc Nat1 Acad Sci USA 8683388342 2. Shimonaka M. Schroeder R, Shimaeaki S, Ling N 1989 Identification of a novel binding protein for insulin-lie growth factors in adult rat serum. Biochem Biophya Ree Commun 165:1&I-195 3. Shimaeaki S, Uchiyama F, Schimonaka M, Ling N 1990 Molecular cloning of the cDNAs encoding a novel insulin-lie growth factor binding protein from rat and human. Mol Endocrinol4:1451-1468 4. LaTour D, Mohan S, Liiart TA, Strong DD 1990 Inhibitory insulin-like growth factor binding protein: cloning, complete sequence and physiological regulation. Mol Endocrinol4:1806-1814 5. Kiefer MC, Masiarz FR, Bauer DM, Zapf J 1991 Identification and molecular cloning of two new 3OkDa insulin-like growth factor
1215
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1216
6. 7. 8.
9.
10.
IGFBP NOMENCLATURE
binding proteins isolated from adult human serum. J Biol Chem 266:9043-9049 Andress DL, Birnbaum RS 1991 A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells. Biochem Biophys Res &mmun 176:213-218 Kiefer MC. Ioh RS. Bauer DM. Zanf J 1991 Molecular clonina of a new human insulin-like growth factor binding protein. Biochem Biophys Res Commun 176:219-225 Bautista C, Baylink DJ, Mohan S 1991 Isolation of a novel insulinlike growth factor (IGF) binding protein from human bone: a potential candidate for fixing IGFII in human bone. Biochem Biophys Res Commun 176:756-763 Shimasaki S, Shimonaka M, Zhang H-P, Ling N 1991 Identification of five different insulin-like growth factor binding protein (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human serum. J Biol Chem 266:16646-10653 Ronhani M. Seeovia B. Whiteburch 0. Binoux M 1991 Purification fro& human ce;ebrospinal fluid of IG’F binding proteins. Isolation of IGFBP-2, an altered form of IGFBP-3 and a new IGFBP species. Growth Regulation 1:125-130
11. Roghani M, Hossenlopp P, Lepage P, Balland A, Binoux M 1989 Isolation from human cerebrospinal fluid of a new insulin-like growth factor binding protein with a selective affinity for IGF-II. FEBS Lett 255:253-258 12. Martin dL, Willetts KE, Baxter RC 1990 Purification and properties of a novel insulin-like growth factor-II binding protein from transformed human Iibroblasts. J Biol Chem 26:4124-4130 13. Forbes B, Ballard FJ, Wallace JC 1990 An IGF binding protein purified from medium conditioned by a human lung tibroblast cell line (He[39)L) has a novel N-terminal sequence. J Endocrinol 126:497-506 14. Zapf J, Kiefer M, Merryweather J, Masiarz F, Bauer D, Born W, Fisher JA, Froesch ER 1990 Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF-I administration and in extrapancreatic tumor hypoglycemia. J Biol Chem 265:14892-14898 15. Shimasaki S, Gao L, Shimonaka M, Ling N 1991 Isolation and molecular cloning of IGF binding protein 6. Mol Endocrinol5:938948
The Endocrine Society. Downloaded from press.endocrine.org by [${individualUser.displayName}] on 15 December 2016. at 03:18 For personal use only. No other uses without permission. . All rights reserved.
Vol. 74, No. 5 Printed
Report on the Nomenclature TABLE
of the IGF Binding
in U.S. A.
Proteins
1. Terminology of the newly discovered IGFBPs Proposed designation hIGFBP-4 hIGFBP-5
hIGFBP-6
a In the publication IGFBP-4. -
Source TESS osteosarcoma Human (rat) serum Human osteoearcoma cell-line Cerebro-spinal fluid Human Bone extract Human (rat) serum Cerebro-spinal fluid Transformed and fetal fibroblaste Human (rat) serum
of Kiefer et al. (Refs. 5 and 7) IGFBP-5 has been temporarily
Participants San Francisco
of the Second International IGF Symposium in interested in the characterization and nomenclature of the insulin-like growth factor binding proteins (IGFBPs) met on Wednesday January 16,199l. It was felt that
the nomenclatureproposaladoptedduring the workshopon the IGF Binding Proteins held in Vancouver in June 1989served its purposeand had found generalacceptanceamongthe investigators around the world involved in IGF and IGFBP research. During the last 2 yr, three more IGFBPs have been discovered and their amino acid sequencedetermined, thus increasing the total number of IGFBPs thus far fully characterized to six. The following is the consensusdevelopedat the San Francisco meeting on the terminology of the newly discovered IGFBPs. In order to avoid confusion in the literature a recommendation was made at this meeting for all researchersin the field to adhereto the proposeddesignation(Table 1). Finally, in order to avoid confusion in the future it was unanimously agreed to request all investigators intending to further enlargethe IGFBP family to report the finding of any new memberof the IGFBP family to Dr. Stenvert L. S. Drop in order to assureproper nomenclature assignment.The minimal requirement would be a significantly different N-terminal or cDNA sequence. Participants of the SecondInternational IGF Symposium.F. J. Ballard, Ph.D., Division of Human Nutrition, CSIRO, Adelaide, Australia; R. C. Baxter, Ph.D., Department of Endocrinology, Royal Prince Alfred Hospital, Camperdown,New South Wales, Australia; M. Binoux, M.D., INSERM U 142, Saint-Antoine, Paris, France; D. R. Clemmons,M.D., Department of Internal Medicine, University of North Carolina, Chapel Hill, North ReceivedOctober7,199l. Address all correspondence and requesta for reprints to: Dr. Stenvert L. S. Drop, P.O. Box 70029.3000 LL Rotterdam, The Netherlands.
N-terminal amino acid sequence DEAIHCPPCSEEKLA
1-5”
LGSFVHCEPCDEKAL
6, 7”-10
ALARCPGCGQGVQAG
5”,11-15
Ref.
designated IGFBP-6, whereas IGFBPB
hae been termed
Carolina; S.L. S. Drop, M.D., Department of Pediatrics,Sophia Children’s Hospital, Erasmus University, Rotterdam, The Netherlands, K. Hall, M.D., Department of Endocrinology, Karolinska Institutet, Stockholm, Sweden;R. L. Hintz, M.D., Department of Pediatrics, Stanford University, Stanford, California; N. Ling, Ph.D., Department of Molecular Endocrinology, The Whittier Institute for Diabetes and Endocrinology, LaJolla, California; S. Mohan, Ph.D., Department of Med. Biochemistry and Physiology, Loma Linda University, Loma Linda, California; M. M. Rechler, M.D., Growth and Development Section,
MCNEB,
NIDDK,
NIH,
Bethesda,
Maryland;
E. M. Rutanen, M.D., Dept. II of Obstetrics and Gynecology, Helsinki, Finland, University Central Hospital, SF-99290,Helsinki, Finland; J. C. Schwander,M.D., Department of Internal Medicine, University of Basal,Switzerland; E. Martin Spencer, M.D., Ph.D., Laboratory of Growth and Development, Children’s Hospital, San Francisco, California; and J. Zapf, M.D. Metabolic Unit, Department of Medicine, University Hospital, Zurich, Switzerland.
References 1. Mohan S, Bautista C, Wergedal J, Baylink DJ 1989 Isolation of an inhibitory insulin-like growth factor (IGF) binding protein from bone cell conditioned medium: a potential local regulator of IGF action. Proc Nat1 Acad Sci USA 8683388342 2. Shimonaka M. Schroeder R, Shimaeaki S, Ling N 1989 Identification of a novel binding protein for insulin-lie growth factors in adult rat serum. Biochem Biophya Ree Commun 165:1&I-195 3. Shimaeaki S, Uchiyama F, Schimonaka M, Ling N 1990 Molecular cloning of the cDNAs encoding a novel insulin-lie growth factor binding protein from rat and human. Mol Endocrinol4:1451-1468 4. LaTour D, Mohan S, Liiart TA, Strong DD 1990 Inhibitory insulin-like growth factor binding protein: cloning, complete sequence and physiological regulation. Mol Endocrinol4:1806-1814 5. Kiefer MC, Masiarz FR, Bauer DM, Zapf J 1991 Identification and molecular cloning of two new 3OkDa insulin-like growth factor
1215
The Endocrine Society. Downloaded from press.endocrine.org by [${individualUser.displayName}] on 15 December 2016. at 03:18 For personal use only. No other uses without permission. . All rights reserved.
1216
6. 7. 8.
9.
10.
IGFBP NOMENCLATURE
binding proteins isolated from adult human serum. J Biol Chem 266:9043-9049 Andress DL, Birnbaum RS 1991 A novel human insulin-like growth factor binding protein secreted by osteoblast-like cells. Biochem Biophys Res &mmun 176:213-218 Kiefer MC. Ioh RS. Bauer DM. Zanf J 1991 Molecular clonina of a new human insulin-like growth factor binding protein. Biochem Biophys Res Commun 176:219-225 Bautista C, Baylink DJ, Mohan S 1991 Isolation of a novel insulinlike growth factor (IGF) binding protein from human bone: a potential candidate for fixing IGFII in human bone. Biochem Biophys Res Commun 176:756-763 Shimasaki S, Shimonaka M, Zhang H-P, Ling N 1991 Identification of five different insulin-like growth factor binding protein (IGFBPs) from adult rat serum and molecular cloning of a novel IGFBP-5 in rat and human serum. J Biol Chem 266:16646-10653 Ronhani M. Seeovia B. Whiteburch 0. Binoux M 1991 Purification fro& human ce;ebrospinal fluid of IG’F binding proteins. Isolation of IGFBP-2, an altered form of IGFBP-3 and a new IGFBP species. Growth Regulation 1:125-130
11. Roghani M, Hossenlopp P, Lepage P, Balland A, Binoux M 1989 Isolation from human cerebrospinal fluid of a new insulin-like growth factor binding protein with a selective affinity for IGF-II. FEBS Lett 255:253-258 12. Martin dL, Willetts KE, Baxter RC 1990 Purification and properties of a novel insulin-like growth factor-II binding protein from transformed human Iibroblasts. J Biol Chem 26:4124-4130 13. Forbes B, Ballard FJ, Wallace JC 1990 An IGF binding protein purified from medium conditioned by a human lung tibroblast cell line (He[39)L) has a novel N-terminal sequence. J Endocrinol 126:497-506 14. Zapf J, Kiefer M, Merryweather J, Masiarz F, Bauer D, Born W, Fisher JA, Froesch ER 1990 Isolation from adult human serum of four insulin-like growth factor (IGF) binding proteins and molecular cloning of one of them that is increased by IGF-I administration and in extrapancreatic tumor hypoglycemia. J Biol Chem 265:14892-14898 15. Shimasaki S, Gao L, Shimonaka M, Ling N 1991 Isolation and molecular cloning of IGF binding protein 6. Mol Endocrinol5:938948
The Endocrine Society. Downloaded from press.endocrine.org by [${individualUser.displayName}] on 15 December 2016. at 03:18 For personal use only. No other uses without permission. . All rights reserved.
