PYRITE ANSWER
Renal Mass: Is It Always Worrisome? Fatma Rabah, MD, MSc,* Fatma A. Ramadhan, FRCPath,w and Alexander P. Chacko, MD*
Right nephrectomy showed a 700 g multilobular cystic mass. The individual cysts were 1 mm to 3 cm in size and filled with serous fluid. The cysts were noncommunicating and lined by cuboidal/flat epithelium. The stroma between cysts contained tubular structures and variable amounts of striated muscle. These features were consistent with multicystic nephroma. Cystic nephroma is an uncommon renal tumor first described in 1892.1 The cysts vary in size and the septa vary in cellularity. It is thought to be the benign end of a spectrum that includes partially differentiated Wilms tumor.2 Males predominate in cases diagnosed under the age of 5, whereas in females it is more frequent in adulthood.3 It usually presents as an asymptomatic mass, but flank pain and
hematuria may occur. Prognosis after resection shows no recurrence. REFERENCES 1. Agrani P, Beckwith JB. Renal neoplasm of childhood. In: Mills SE, ed. Sternberg’s Diagnostic Surgical Pathology. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2004:2016–2019. 2. Joshi VV, Beckwith JB. Multilocular cyst of the kidney (cystic nephroma) and cystic, partially differentiated nephroblastoma: terminology and criteria for diagnosis. Cancer. 1989;64:466–479. 3. Lane BR, Campbell SC, Remer EM, et al. Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney: clinical, radiographic, and pathologic characteristics. Urology. 2008;71:1142–1148.
Received for publication January 27, 2014; accepted January 27, 2014. From the *Child Health Department, Sultan Qaboos University Hospital; and wDepartment of Histopathology, Royal Hospital, Muscat, Oman. The authors declare no conflict of interest. Reprints: Fatma Rabah, MD, MSc, Child Health Department, Sultan Qaboos University Hospital, Postal code 123, Zip code 38, AlKoud, Muscat, Oman (e-mail: [email protected]. Copyright r 2014 by Lippincott Williams & Wilkins
J Pediatr Hematol Oncol
Volume 36, Number 5, July 2014
www.jpho-online.com |
411
Renal Mass: Is It Always Worrisome? Fatma Rabah, MD, MSc,* Fatma A. Ramadhan, FRCPath,w and Alexander P. Chacko, MD*
Right nephrectomy showed a 700 g multilobular cystic mass. The individual cysts were 1 mm to 3 cm in size and filled with serous fluid. The cysts were noncommunicating and lined by cuboidal/flat epithelium. The stroma between cysts contained tubular structures and variable amounts of striated muscle. These features were consistent with multicystic nephroma. Cystic nephroma is an uncommon renal tumor first described in 1892.1 The cysts vary in size and the septa vary in cellularity. It is thought to be the benign end of a spectrum that includes partially differentiated Wilms tumor.2 Males predominate in cases diagnosed under the age of 5, whereas in females it is more frequent in adulthood.3 It usually presents as an asymptomatic mass, but flank pain and
hematuria may occur. Prognosis after resection shows no recurrence. REFERENCES 1. Agrani P, Beckwith JB. Renal neoplasm of childhood. In: Mills SE, ed. Sternberg’s Diagnostic Surgical Pathology. 4th ed. Philadelphia: Lippincott Williams & Wilkins; 2004:2016–2019. 2. Joshi VV, Beckwith JB. Multilocular cyst of the kidney (cystic nephroma) and cystic, partially differentiated nephroblastoma: terminology and criteria for diagnosis. Cancer. 1989;64:466–479. 3. Lane BR, Campbell SC, Remer EM, et al. Adult cystic nephroma and mixed epithelial and stromal tumor of the kidney: clinical, radiographic, and pathologic characteristics. Urology. 2008;71:1142–1148.
Received for publication January 27, 2014; accepted January 27, 2014. From the *Child Health Department, Sultan Qaboos University Hospital; and wDepartment of Histopathology, Royal Hospital, Muscat, Oman. The authors declare no conflict of interest. Reprints: Fatma Rabah, MD, MSc, Child Health Department, Sultan Qaboos University Hospital, Postal code 123, Zip code 38, AlKoud, Muscat, Oman (e-mail: [email protected]. Copyright r 2014 by Lippincott Williams & Wilkins
J Pediatr Hematol Oncol
Volume 36, Number 5, July 2014
www.jpho-online.com |
411
