€ 1991S. Karger AG. Basel 0028-2766/910572 OI 56S2.75/0

Nephron 1991;57:156-163

Renal Concentrating Defect in Protein Malnutrition: The Role of the Thick Ascending Limb of Henle and Inner Medullary Collecting Duct Lucia H. Kudo. Maña H.M. Sliimizu, Antonio C. Seguro, Antonino S. Rocha Laboratorio de Pesquisa Básica do Departamento de Clínica Médica da Faculdadede Medicinada Universidade de Sao Paulo, Brasil

KeyWords. Protein malnutrition • Urinary concentration • Thick ascending limb of Henle • Inner medullary collecting duct Abstract. The present study was carried out to examine the effect of chronic dietary protein restriction on renal water handling in the rat. During hypotonic saline infusion, the malnourished rats showed a lower free-water clearance, corrected by inulin clearance (7.2 ±0.4%), than normal rats (13.6 ± 2.5%, p < 0.051), although the fractional distal delivery of sodium did not differ from normal. Throughout hypertonic saline diuresis the free-water reabsorp­ tion (T cC hjo) corrected by inulin clearance was lower in malnourished rats (6.62 ±0.64%) than in control animals (9.25 ±0.62, p

Renal concentrating defect in protein malnutrition: the role of the thick ascending limb of Henle and inner medullary collecting duct.

The present study was carried out to examine the effect of chronic dietary protein restriction on renal water handling in the rat. During hypotonic sa...
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