Accepted Article

Article Type: Original Article

Remineralizing potential of CPP-ACP crèmes with and without fluoride in artificial enamel lesions.

Remineralization potencial of CPP-ACP Patrícia Regina Almeida de Oliveiraa, Graduate student Ana Beatriz Monteiro Fonsecab, Associate professor Eduardo Moreira da Silvac, Associate professor Thereza Christina Lopes Coutinhoa, Associate professor Monica Almeida Tostesa, Associate professor a

Department of Pediatric Dentistry, School of Dentistry, Fluminense Federal University, Rua Mário Santos Braga, nº 30, Campus Valonguinho, Niterói, Rio de Janeiro, Brazil.

b

Department of Statistics, Fluminense Federal University, Rua Mário Santos Braga, s/n 7o andar, Campus Valonguinho, Niterói, Rio de Janeiro, Brazil.

c

Analitical Laboratory of Restorative Biomaterials – LABiom-R, School of Dentistry, Federal Fluminense University, Rua Mário Santos Braga, nº 30, Niterói, Rio de Janeiro, Brazil *Corresponding author: Dra. Monica Tostes, Rua Presidente Backer, 337/903, Icaraí, Niterói, RJ – CEP 24240-045 Brazil, e-mail address: [email protected]. Tel55(21)26299829

Keywords: Dental caries, Microhardness, CPP-ACP, Fluoride Remineralization potencial of CPP-ACP ABSTRACT: Objective: This study evaluated the effect of pastes containing casein phosphopeptide– amorphous calcium phosphate (CPP–ACP) with and without fluoride on enamel demineralization. Methods: Human enamel blocks were used and after incipient-caries-like lesions were formed, they were assigned to four groups: G1: saliva; G2: MI Paste (RecaldentTM); G3: MI Paste Plus (RecaldentTM 900 ppm as NaF), and G4: CrestTM (1.100 ppm as NaF). The specimens were soaked in demineralizing solution for 6 hours and remineralized in artificial This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1111/adj.12305 This article is protected by copyright. All rights reserved.

Accepted Article

saliva for 18 hours alternatively for 10 days. The dentifrice was prepared with deionized water in a 1:3 proportion (w/w) or applied undiluted in the case of the CPP-ACP formula. Demineralized enamel changes were analyzed by surface microhardness (SMH), 3Dprofilometry and SEM. Data were analyzed by nonparametric Kruskal-Wallis and Mann Whitney tests comparisons and one-way ANOVA and Tukey’s HSD post hoc test (α = 0.05). Results: The SMH values observed in G2 (47.8±28.5) and G3 (53.6±27.6) groups were different from that of G4 (90.2±17.1), which were significantly higher than that found in G1 (39.4± 14.2). The %SMH was significantly lower in G4 when compared to G1 (p

Remineralizing potential of CPP-ACP crèmes with and without fluoride in artificial enamel lesions.

This study evaluated the effect of pastes containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) with and without fluoride on enamel d...
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