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J Alzheimers Dis. Author manuscript; available in PMC 2017 September 21. Published in final edited form as: J Alzheimers Dis. 2017 ; 60(1): 211–223. doi:10.3233/JAD-170031.
Relative Incidence of Seizures and Myoclonus in Alzheimer’s Disease, Dementia with Lewy Bodies, and Frontotemporal Dementia Alexander J. Beagle1,*, Sonja M. Darwish1,*, Kamalini G. Ranasinghe1, Alice L. La1, Elissaios Karageorgiou1,2, and Keith A. Vossel1,3
Author Manuscript
1Memory
and Aging Center, Department of Neurology, University of California, San Francisco,
USA. 2Neurological
Institute of Athens, Athens, Greece.
3N.
Bud Grossman Center for Memory Research and Care, Institute for Translational Neuroscience, and Department of Neurology, University of Minnesota, Minneapolis, MN, USA.
Abstract Background—Patients with Alzheimer’s disease (AD) are more prone to seizures and myoclonus, but relative risk of these symptoms among other dementia types is unknown.
Author Manuscript
Objective—To determine incidence of seizures and myoclonus in the three most common neurodegenerative dementias: AD, dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD). Methods—Our institution’s medical records were reviewed for new-onset unprovoked seizures and myoclonus in patients meeting criteria for AD (n=1,320), DLB (n=178), and FTD (n=348). Cumulative probabilities of developing seizures and myoclonus were compared between diagnostic groups, whereas age-stratified incidence rates were determined relative to control populations.
Author Manuscript
Results—The cumulative probability of developing seizures after disease onset was 11.5% overall, highest in AD (13.4%) and DLB (14.7%) and lowest in FTD (3.0%). The cumulative probability of developing myoclonus was 42.1% overall, highest in DLB (58.1%). The seizure incidence rates, relative to control populations, were nearly 10 fold in AD and DLB, and 6 fold in FTD. Relative seizure rates increased with earlier age-at-onset in AD (age
J Alzheimers Dis. Author manuscript; available in PMC 2017 September 21. Published in final edited form as: J Alzheimers Dis. 2017 ; 60(1): 211–223. doi:10.3233/JAD-170031.
Relative Incidence of Seizures and Myoclonus in Alzheimer’s Disease, Dementia with Lewy Bodies, and Frontotemporal Dementia Alexander J. Beagle1,*, Sonja M. Darwish1,*, Kamalini G. Ranasinghe1, Alice L. La1, Elissaios Karageorgiou1,2, and Keith A. Vossel1,3
Author Manuscript
1Memory
and Aging Center, Department of Neurology, University of California, San Francisco,
USA. 2Neurological
Institute of Athens, Athens, Greece.
3N.
Bud Grossman Center for Memory Research and Care, Institute for Translational Neuroscience, and Department of Neurology, University of Minnesota, Minneapolis, MN, USA.
Abstract Background—Patients with Alzheimer’s disease (AD) are more prone to seizures and myoclonus, but relative risk of these symptoms among other dementia types is unknown.
Author Manuscript
Objective—To determine incidence of seizures and myoclonus in the three most common neurodegenerative dementias: AD, dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD). Methods—Our institution’s medical records were reviewed for new-onset unprovoked seizures and myoclonus in patients meeting criteria for AD (n=1,320), DLB (n=178), and FTD (n=348). Cumulative probabilities of developing seizures and myoclonus were compared between diagnostic groups, whereas age-stratified incidence rates were determined relative to control populations.
Author Manuscript
Results—The cumulative probability of developing seizures after disease onset was 11.5% overall, highest in AD (13.4%) and DLB (14.7%) and lowest in FTD (3.0%). The cumulative probability of developing myoclonus was 42.1% overall, highest in DLB (58.1%). The seizure incidence rates, relative to control populations, were nearly 10 fold in AD and DLB, and 6 fold in FTD. Relative seizure rates increased with earlier age-at-onset in AD (age
