Original Paper Received: January 14, 2014 Accepted after revision: March 28, 2014 Published online: December 2, 2014

Acta Haematol 2015;133:295–299 DOI: 10.1159/000362531

Relationships of Mean Platelet Volume and Plasma Thrombopoietin with Glycocalicin Levels in Thrombocytopenic Patients Svetlana G. Khaspekova a Olga N. Shustova a Nina V. Golubeva a Sergey A. Vasiliev b Alexey V. Mazurov a   

 

 

 

 

Russian Cardiology Research and Production Complex, Russian Ministry of Health, and b Haematology Research Center, Russian Academy of Medical Sciences, Moscow, Russian Federation  

 

Key Words Glycocalicin · Idiopathic thrombocytopenic purpura · Mean platelet volume · Platelet-associated IgG · Thrombopoietin

Abstract Backgrounds/Aims: Relationships of mean platelet volume (MPV) and thrombopoietin (TPO) with platelet turnover assessed by glycocalicin measurement were evaluated in thrombocytopenic patients. Methods: MPV, glycocalicin and platelet-associated IgG (PA-IgG) were measured in 107 patients with idiopathic thrombocytopenic purpura (ITP) and 19 patients with hypoproductive thrombocytopenia (HPT; aplastic anemia or leukemia), and TPO was measured in 53 ITP and 12 HPT patients. All the included ITP patients had PA-IgG ≥300% and glycocalicin ≥50% of control values, and HPT patients had PA-IgG