HHS Public Access Author manuscript Author Manuscript
Am J Perinatol. Author manuscript; available in PMC 2017 January 31. Published in final edited form as: Am J Perinatol. 2016 January ; 33(1): 114–121. doi:10.1055/s-0035-1562928.
Relationship of early pregnancy waist to hip ratio versus body mass index with gestational diabetes and insulin resistance
Author Manuscript
Sanmaan K. Basraon, M.D., Lisa Mele, Sc.M., Leslie Myatt, Ph.D., James M. Roberts, M.D., John C. Hauth, M.D., Kenneth J. Leveno, M.D., Michael W. Varner, M.D., Ronald J. Wapner, M.D., John M. Thorp Jr, M.D., Alan M. Peaceman, M.D., Susan M. Ramin, M.D., Anthony Sciscione, D.O., M.Sc., Jorge E. Tolosa, M.D., M.S.C.E., Yoram Sorokin, M.D., and for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network Departments of Obstetrics and Gynecology of University of Texas Medical Branch, Galveston, TX (S.K.B.); George Washington University, Biostatistics Center, Washington DC (L.M.); University of Cincinnati, Cincinnati, OH (L.M.); University of Pittsburgh, Pittsburgh, PA (J.M.R.); University of Alabama at Birmingham, Birmingham, AL (J.C.H.); University of Texas Southwestern Medical Center, Dallas, TX (K.J.L.); University of Utah, Salt Lake City, UT (M.W.V.); Columbia University, New York, NY (R.J.W.); University of North Carolina at Chapel Hill, Chapel Hill, NC (J.M.T.); Northwestern University, Chicago, IL (A.M.P.); University of Texas Health Science Center at Houston-Children’s Memorial Hermann Hospital, Houston, TX (S.M.R.); Drexel University, Philadelphia, PA (A.S.); Oregon Health & Science University, Portland, OR (J.E.T.); and Wayne State University, Detroit, MI (Y.S.).
Author Manuscript
Abstract Objective—To determine the risk of gestational diabetes (GDM) and insulin resistance (IR) in obesity defined by body mass index (BMI), waist-to-hip ratio (WHR) or both combined.
Author Manuscript
Methods—Secondary analysis of a randomized multicenter trial of antioxidant supplementation versus placebo in nulliparous low-risk women to prevent pregnancy associated hypertension. Women between 9–16 weeks with data for WHR and BMI were analyzed for GDM (n=2300). Those with fasting glucose and insulin between 22–26 weeks (n=717) were analyzed for IR by homeostasis model assessment of insulin resistance (HOMA-IR; normal≤75thpercentile). WHR and BMI were categorized as normal (WHR
Am J Perinatol. Author manuscript; available in PMC 2017 January 31. Published in final edited form as: Am J Perinatol. 2016 January ; 33(1): 114–121. doi:10.1055/s-0035-1562928.
Relationship of early pregnancy waist to hip ratio versus body mass index with gestational diabetes and insulin resistance
Author Manuscript
Sanmaan K. Basraon, M.D., Lisa Mele, Sc.M., Leslie Myatt, Ph.D., James M. Roberts, M.D., John C. Hauth, M.D., Kenneth J. Leveno, M.D., Michael W. Varner, M.D., Ronald J. Wapner, M.D., John M. Thorp Jr, M.D., Alan M. Peaceman, M.D., Susan M. Ramin, M.D., Anthony Sciscione, D.O., M.Sc., Jorge E. Tolosa, M.D., M.S.C.E., Yoram Sorokin, M.D., and for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network Departments of Obstetrics and Gynecology of University of Texas Medical Branch, Galveston, TX (S.K.B.); George Washington University, Biostatistics Center, Washington DC (L.M.); University of Cincinnati, Cincinnati, OH (L.M.); University of Pittsburgh, Pittsburgh, PA (J.M.R.); University of Alabama at Birmingham, Birmingham, AL (J.C.H.); University of Texas Southwestern Medical Center, Dallas, TX (K.J.L.); University of Utah, Salt Lake City, UT (M.W.V.); Columbia University, New York, NY (R.J.W.); University of North Carolina at Chapel Hill, Chapel Hill, NC (J.M.T.); Northwestern University, Chicago, IL (A.M.P.); University of Texas Health Science Center at Houston-Children’s Memorial Hermann Hospital, Houston, TX (S.M.R.); Drexel University, Philadelphia, PA (A.S.); Oregon Health & Science University, Portland, OR (J.E.T.); and Wayne State University, Detroit, MI (Y.S.).
Author Manuscript
Abstract Objective—To determine the risk of gestational diabetes (GDM) and insulin resistance (IR) in obesity defined by body mass index (BMI), waist-to-hip ratio (WHR) or both combined.
Author Manuscript
Methods—Secondary analysis of a randomized multicenter trial of antioxidant supplementation versus placebo in nulliparous low-risk women to prevent pregnancy associated hypertension. Women between 9–16 weeks with data for WHR and BMI were analyzed for GDM (n=2300). Those with fasting glucose and insulin between 22–26 weeks (n=717) were analyzed for IR by homeostasis model assessment of insulin resistance (HOMA-IR; normal≤75thpercentile). WHR and BMI were categorized as normal (WHR
