Original Relationship of catecholamine obesity, and nutrient intake and elderly men13 B Young, Sparrow,

Rebecca J Troisi, Scott and Lewis Landsberg

ABSTRACT nerves

Catecholamine

and

the adrenal

dopamine measured

(DA), epinephrine in 24-h collections

the Normative Average daily

test

Aging Study intakes ofenergy

excretion variables.

related

to age,

age.

of the Veterans and macronutrients

of body

DA

size

and

and

fatness.

Excretion

related adjusted

to total CHO

food

frequency of sodium

of individual

con-

affects catecontent of was of

analyses

NE

fatness, rates

were Epi

ofall

was

three

energy intake consumption.

adjustments

negatively

Am

for

to measures

related

KEY

Age, obesity,

fat, energy

dopamine,

related

intake,

protein,

directly

(DA),

evidence

suggests

norepinephrine

as free amines

components derives ripheral

ofa

Nuir

1992;56:

norepinephrine, epinephrine,

that

(NE),

in urine,

peripheral

principally sympathetic

the

and

originate

car-

catecholamines

epinephrine primarily

chromaffin

system

from the adrenal nerves, although

in proximal

entially ences

affects that

can

the

tubular activity

medulla under

Epi in metabolic

jects

(1, 6, 9, 10).

in the

studies Whether

cells (2-4). of these

be observed

and portant mans

from

any

of these

dietary

present

J C/in

study

is part

especially Nutr

1992:56:827-34.

of an investigation in relation Printed

and

abdomen-hip

status

(12,

ratio],

total

energy

This anthro-

intake,

13).

Aging

Study

study established Details ofthe study

volunteers

is an ongoing

were initially

tolic blood pressure was > 140 mm Hg or iftheir pressure was > 90 mm Hg. Body composition

factors

2

im-

health disease,

© 1992 American

concentrations

disease,

were

diabetes

not screening

mellitus,

cancer,

peptic

were criteria for exexcluded if their sys-

criteria.

diastolic blood and circulating Although

neither

I From the Charles A Dana Research Institute, Thorndike Laboratory, and Channing Laboratory. Department of Medicine, Harvard Medical School, Beth Israel Hospital, and Brigham and Women’s Hospital, Boston.

excretion in huis, however, not of potential

lipid

heart

criteria or the pres-

re-

subare

of coronary

mul-

on the basis of din-

Epi

NE,

or in human

selected

and electrocardiographic at outset. A history

ulcer, gout, recurrent asthma, or bronchitis clusion from the study. Subjects were also

differ-

of DA,

longitudinal,

by the Veterans Administration protocol were presented elsewhere

ence

differ-

systems,

to cardiovascular in USA.

of sympa-

as it is in animals

ex-

different

intake

excretion

(5-8)

in animals

determinant population,

do-

and NE from pestressful conditions

chromaffin

determinants of urinary catecholamine outside of a clinical research protocol

consequences, Am

(BMI)

Normative

tidisciplinary in 1963.

(Epi),

(or systems).

Dietary

urinary

con-

subjects

( I 1). Male

known. The

index

Studi’

sodium

the adrenal medullary release of NE may also be quantitatively important ( 1). DA, in contrast, predominantly reflects nal decarboxylation of circulating 3,4-dihydroxyphenylalanine

(DOPA)

important

in a free-living

ical, laboratory, radiological, to provide a healthy population

Accumulating creted

is an

activity

and

to catecholamine to test whether

Methods

to energy-

Introduction

pamine

in addition opportunity

insulin-glucose

The WORDS

variables were measured the study provided an

as reflected

dietary

to body

were

J C/in

mass and

827-34.

bohydrate,

Because

composition

thoadrenal

activity

excretion.

pometric variables on catecholamine excretion in a sample of 572 participants in the Normative Aging Study of the Veterans Administration (11). Urinary excretion of NE, but not of Epi, was reported previously to be related positively to obesity [body

related

inversely

in sympathoadrenal

questionnaire excretion. Cate-

catecholamines

and

stitutional excretion,

dietary

differences catecholamine

and human subjects under more controlled circumstances. report examined the impact of dietary intake, age, and

included

positively

in urinary

Administration. were assessed

was also examined in relation to anthroBecause DA and Epi excretion were inversely

all subsequent

Although

diet urinary

under

size,

R Parker,

sympathetic

by diet

whether men, the

Donna

(Epi), or norepinephnne (NE) provided by 572 participants

by means of a semiquantitative and sodium intake by quantitation cholamine pometric

from

is influenced

trolled research conditions. To cholamine excretion in free-living

excretion to body in middle-aged

T Weiss,

release

medulla

Communications-general

Supported

01032

Public

Health

Research

Service

grants

Service

of the Veterans

HL

3787

1 and

RR

Adminis-

tration. 3 Address reprint requests to JB Young, Northwestern University Medical School, Searle Bldg 3-489, 320 East Superior Street. Chicago, IL 60611. Received May 22, 1991.

Accepted

Society

by US

and by the Medical

for Clinical

for publication

Nutrition

October

9, 1991.

827

Downloaded from https://academic.oup.com/ajcn/article-abstract/56/5/827/4715516 by guest on 04 December 2018

James David

Research

828

YOUNG

racial

nor

ethnic

origin

pants

are

almost

all Caucasian

± 7.9

y (i ± SD),

Subject

range

criterion,

men.

43-85

study

Subjects

were

particiaged

Subjects

report

a physical

Subjects

undergo

an

after overnight abstinence series of anthropometric ticipant

with

the

erect

ance-beam Height

oral

together.

converted

against

to centimeters.

are made in undershorts

BMI

axis of the body. Hip 0. 1 cm at the greatest

domen-hip

ratio

refers

circumference protrusion

to the ratio

circumference. The participants current, or former smokers on

To be considered

a former

framed

from

Dietary

questionnaire

Dietary titative received

smoking

data food the

to the assistant

study

center.

and

obtained

to the

Abof body

checked

by two

other

and

must

have

re-

a semiquan-

of the

food

item. Variables

intakes

Residuals

from

the

study

were the

on total energy on

coded

questions

(RJT,

to the value

at the

mean

total

intake

was

estimated

tea,

on Paffenbarger

information

of flights

of stairs

of various

climbed

physical

physical-activity

per

and

this

717

(81%)

time,

because

from

dards ofthe Development

Subcommittee Department

Human Studies Committee,

Clinic,

in accord

activity.

used

assessed with

from Mi/d)

a 24-h

urine

cluded

the

and

brought

in at the

a questionnaire

time

collected of their

eliciting

A total

because

time

was

an incomplete

were

missing,

Based

and

16 samples or thorazine

urine collection. Five additional subjects the analysis because their total daily energy

1 presents

range either

set a priori (2.51underor overre-

had to be excluded because of of the study variables. Finally,

were excluded. After elimination of 572 subjects were available for anal-

the descriptive

between from

the

the

included

study

statistics

and

sample

of study

for the study

sample.

excluded

were

shorter

cases:

subjects

on

average

sample*

Age (y) Weight (kg) Height (m) BMIt Abdomen circumference Hip circumference (cm) Abdomen-hip ratio Total energy (Mi/d)

asking pace,

and

to derive

total

a

energy stan-

Research Affairs

and Out-

at home routine information

15

Relationship of catecholamine excretion to body size, obesity, and nutrient intake in middle-aged and elderly men.

Catecholamine release from sympathetic nerves and the adrenal medulla is influenced by diet under controlled research conditions. To test whether diet...
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