Original Relationship of catecholamine obesity, and nutrient intake and elderly men13 B Young, Sparrow,
Rebecca J Troisi, Scott and Lewis Landsberg
ABSTRACT nerves
Catecholamine
and
the adrenal
dopamine measured
(DA), epinephrine in 24-h collections
the Normative Average daily
test
Aging Study intakes ofenergy
excretion variables.
related
to age,
age.
of the Veterans and macronutrients
of body
DA
size
and
and
fatness.
Excretion
related adjusted
to total CHO
food
frequency of sodium
of individual
con-
affects catecontent of was of
analyses
NE
fatness, rates
were Epi
ofall
was
three
energy intake consumption.
adjustments
negatively
Am
for
to measures
related
KEY
Age, obesity,
fat, energy
dopamine,
related
intake,
protein,
directly
(DA),
evidence
suggests
norepinephrine
as free amines
components derives ripheral
ofa
Nuir
1992;56:
norepinephrine, epinephrine,
that
(NE),
in urine,
peripheral
principally sympathetic
the
and
originate
car-
catecholamines
epinephrine primarily
chromaffin
system
from the adrenal nerves, although
in proximal
entially ences
affects that
can
the
tubular activity
medulla under
Epi in metabolic
jects
(1, 6, 9, 10).
in the
studies Whether
cells (2-4). of these
be observed
and portant mans
from
any
of these
dietary
present
J C/in
study
is part
especially Nutr
1992:56:827-34.
of an investigation in relation Printed
and
abdomen-hip
status
(12,
ratio],
total
energy
This anthro-
intake,
13).
Aging
Study
study established Details ofthe study
volunteers
is an ongoing
were initially
tolic blood pressure was > 140 mm Hg or iftheir pressure was > 90 mm Hg. Body composition
factors
2
im-
health disease,
© 1992 American
concentrations
disease,
were
diabetes
not screening
mellitus,
cancer,
peptic
were criteria for exexcluded if their sys-
criteria.
diastolic blood and circulating Although
neither
I From the Charles A Dana Research Institute, Thorndike Laboratory, and Channing Laboratory. Department of Medicine, Harvard Medical School, Beth Israel Hospital, and Brigham and Women’s Hospital, Boston.
excretion in huis, however, not of potential
lipid
heart
criteria or the pres-
re-
subare
of coronary
mul-
on the basis of din-
Epi
NE,
or in human
selected
and electrocardiographic at outset. A history
ulcer, gout, recurrent asthma, or bronchitis clusion from the study. Subjects were also
differ-
of DA,
longitudinal,
by the Veterans Administration protocol were presented elsewhere
ence
differ-
systems,
to cardiovascular in USA.
of sympa-
as it is in animals
ex-
different
intake
excretion
(5-8)
in animals
determinant population,
do-
and NE from pestressful conditions
chromaffin
determinants of urinary catecholamine outside of a clinical research protocol
consequences, Am
(BMI)
Normative
tidisciplinary in 1963.
(Epi),
(or systems).
Dietary
urinary
con-
subjects
( I 1). Male
known. The
index
Studi’
sodium
the adrenal medullary release of NE may also be quantitatively important ( 1). DA, in contrast, predominantly reflects nal decarboxylation of circulating 3,4-dihydroxyphenylalanine
(DOPA)
important
in a free-living
ical, laboratory, radiological, to provide a healthy population
Accumulating creted
is an
activity
and
to catecholamine to test whether
Methods
to energy-
Introduction
pamine
in addition opportunity
insulin-glucose
The WORDS
variables were measured the study provided an
as reflected
dietary
to body
were
J C/in
mass and
827-34.
bohydrate,
Because
composition
thoadrenal
activity
excretion.
pometric variables on catecholamine excretion in a sample of 572 participants in the Normative Aging Study of the Veterans Administration (11). Urinary excretion of NE, but not of Epi, was reported previously to be related positively to obesity [body
related
inversely
in sympathoadrenal
questionnaire excretion. Cate-
catecholamines
and
stitutional excretion,
dietary
differences catecholamine
and human subjects under more controlled circumstances. report examined the impact of dietary intake, age, and
included
positively
in urinary
Administration. were assessed
was also examined in relation to anthroBecause DA and Epi excretion were inversely
all subsequent
Although
diet urinary
under
size,
R Parker,
sympathetic
by diet
whether men, the
Donna
(Epi), or norepinephnne (NE) provided by 572 participants
by means of a semiquantitative and sodium intake by quantitation cholamine pometric
from
is influenced
trolled research conditions. To cholamine excretion in free-living
excretion to body in middle-aged
T Weiss,
release
medulla
Communications-general
Supported
01032
Public
Health
Research
Service
grants
Service
of the Veterans
HL
3787
1 and
RR
Adminis-
tration. 3 Address reprint requests to JB Young, Northwestern University Medical School, Searle Bldg 3-489, 320 East Superior Street. Chicago, IL 60611. Received May 22, 1991.
Accepted
Society
by US
and by the Medical
for Clinical
for publication
Nutrition
October
9, 1991.
827
Downloaded from https://academic.oup.com/ajcn/article-abstract/56/5/827/4715516 by guest on 04 December 2018
James David
Research
828
YOUNG
racial
nor
ethnic
origin
pants
are
almost
all Caucasian
± 7.9
y (i ± SD),
Subject
range
criterion,
men.
43-85
study
Subjects
were
particiaged
Subjects
report
a physical
Subjects
undergo
an
after overnight abstinence series of anthropometric ticipant
with
the
erect
ance-beam Height
oral
together.
converted
against
to centimeters.
are made in undershorts
BMI
axis of the body. Hip 0. 1 cm at the greatest
domen-hip
ratio
refers
circumference protrusion
to the ratio
circumference. The participants current, or former smokers on
To be considered
a former
framed
from
Dietary
questionnaire
Dietary titative received
smoking
data food the
to the assistant
study
center.
and
obtained
to the
Abof body
checked
by two
other
and
must
have
re-
a semiquan-
of the
food
item. Variables
intakes
Residuals
from
the
study
were the
on total energy on
coded
questions
(RJT,
to the value
at the
mean
total
intake
was
estimated
tea,
on Paffenbarger
information
of flights
of stairs
of various
climbed
physical
physical-activity
per
and
this
717
(81%)
time,
because
from
dards ofthe Development
Subcommittee Department
Human Studies Committee,
Clinic,
in accord
activity.
used
assessed with
from Mi/d)
a 24-h
urine
cluded
the
and
brought
in at the
a questionnaire
time
collected of their
eliciting
A total
because
time
was
an incomplete
were
missing,
Based
and
16 samples or thorazine
urine collection. Five additional subjects the analysis because their total daily energy
1 presents
range either
set a priori (2.51underor overre-
had to be excluded because of of the study variables. Finally,
were excluded. After elimination of 572 subjects were available for anal-
the descriptive
between from
the
the
included
study
statistics
and
sample
of study
for the study
sample.
excluded
were
shorter
cases:
subjects
on
average
sample*
Age (y) Weight (kg) Height (m) BMIt Abdomen circumference Hip circumference (cm) Abdomen-hip ratio Total energy (Mi/d)
asking pace,
and
to derive
total
a
energy stan-
Research Affairs
and Out-
at home routine information
15