Relationship Between the Epicardial Fat Thickness and Total Atrial Conduction Time in Patients with Lone Paroxysmal Atrial Fibrillation ¨ U˘gur Canpolat, Kudret Aytemir, Necla Ozer, Ali Oto PII: DOI: Reference:

S0167-5273(15)00330-7 doi: 10.1016/j.ijcard.2015.03.091 IJCA 19855

To appear in:

International Journal of Cardiology

Received date: Accepted date:

17 January 2015 7 March 2015

¨ Please cite this article as: Canpolat U˘gur, Aytemir Kudret, Ozer Necla, Oto Ali, Relationship Between the Epicardial Fat Thickness and Total Atrial Conduction Time in Patients with Lone Paroxysmal Atrial Fibrillation, International Journal of Cardiology (2015), doi: 10.1016/j.ijcard.2015.03.091

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ACCEPTED MANUSCRIPT Relationship Between the Epicardial Fat Thickness and Total Atrial Conduction Time in Patients with Lone Paroxysmal Atrial Fibrillation

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Running Title: EFT and TACT in Lone AF

Kudret Aytemir, MD, Professor, FESC (1) Necla ÖZER, MD, Professor, FESC (1)

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Ali OTO, MD, Professor, FESC, FACC, FHRS (1)

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Uğur CANPOLAT, MD (1)

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(1) Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey Corresponding Author

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Uğur Canpolat, MD. Hacettepe University Faculty of Medicine, Department of Cardiology,

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06100, Sıhhiye, Ankara, Turkey. Tel: +90 312 305 17 80. Fax: +90 312 305 41 37.

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Email: [email protected]

Conflict of Disclosure Statement: There is no conflict of interest related with our

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manuscript and was not supported by any grant or institution. Word count: 1121 words (excluding title page, references and figure legends) Key words: Atrial fibrillation; epicardial fat; atrial conduction time; remodelling

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ACCEPTED MANUSCRIPT Letter to Editor, The pathophysiology of atrial fibrillation (AF) is complex and has not been

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completely understood yet. However, current knowledge suggests that both electrical

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and structural remodelling of the atrium and the activation of inflammatory pathways may represent a prerequisite for AF (1,2). Total atrial conduction time (TACT) which can

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be simply assessed by using tissue Doppler imaging (PA-TDI duration) and has been proposed as a marker of the extent of both electrical and structural remodelling of the

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atria (3). Furthermore, epicardial fat, asserted as an endocrine active organ, is thougt to be an important source of proinflammatory mediators and given its direct neighboring to

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heart potentially takes play in the pathophysiology of AF (4). Previous studies demonstrated that total or regional amount of epicardial fat has been associated with the new onset or recurrent AF (5,6). Therefore, it was the goal of this study to further

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confirm the association of echocardiographically measured epicardial fat thickness (EFT)

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with the TACT in patients with lone paroxysmal AF.

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This prospective study is consisted of 50 patients with lone paroxysmal AF and 50 healthy subjects. Patients who were at the age of ≥60 years, had pregnancy, valvular heart disease, connective tissue disease, renal dysfunction (serum creatinine levels ≥1.5

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mg/dl), hepatic disorders, concomitant inflammatory, infectious or neoplastic diseases or any other systemic disorders including thyroid disorders were excluded from the study. The study was in compliance with the principles outlined in the Declaration of Helsinki and approved by Institutional Ethics Committee. Paroxysmal AF is defined as self-terminating episode, usually within 48 hours, may continue for up to 7 days (7). Lone AF was defined in patients who were

Relationship between the epicardial fat thickness and total atrial conduction time in patients with lone paroxysmal atrial fibrillation.

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