870
Li et al. / J Zhejiang Univ-Sci B (Biomed & Biotechnol) 2014 15(10):870-878
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) ISSN 1673-1581 (Print); ISSN 1862-1783 (Online) www.zju.edu.cn/jzus; www.springerlink.com E-mail: [email protected]
Relationship between post-operative cognitive dysfunction and regional cerebral oxygen saturation and β-amyloid protein* Xi-ming LI†§1,2, Ming-tao SHAO§3, Jian-juan WANG4, Yue-lan WANG†‡1 (1Department of Anesthesiology, Affiliated Qianfoshan Hospital of Shandong University, Jinan 250014, China) (2Department of Anesthesiology, Linyi City People's Hospital, Linyi 276000, China) 3
( Department of Emergency Surgery, Linyi City People's Hospital, Linyi 276000, China) 4
( Department of Anesthesiology, Shandong Lunan Ophthalmologic Hospital, Linyi 276000, China) †
E-mail: [email protected]; [email protected]
Received May 6, 2014; Revision accepted Aug. 7, 2014; Crosschecked Sept. 21, 2014
Abstract: Objective: To investigate the relationship between post-operative cognitive dysfunction (POCD) and regional cerebral oxygen saturation (rSO2) and β-amyloid protein (Aβ) in patients undergoing laparoscopic pancreaticoduodenectomy. Methods: Fifty patients undergoing elective laparoscopic pancreaticoduodenectomy received five groups of neuropsychological tests 1 d pre-operatively and 7 d post-operatively, with continuous monitoring of rSO2 intra-operatively. Before anesthesia induction (t0), at the beginning of laparoscopy (t1), and at the time of pneumoperitoneum 120 min (t2), pneumoperitoneum 240 min (t3), pneumoperitoneum 480 min (t4), the end of pneumoperitoneum (t5), and 24 h after surgery, jugular venous blood was drawn respectively for the measurement of Aβ by enzyme-linked immunosorbent assay (ELISA). Results: Twenty-one cases of the fifty patients suffered from POCD after operation. We found that the maximum percentage drop in rSO2 (rSO2, %max) was significantly higher in the POCD group than in the non-POCD group. The rSO2, %max value of over 10.2% might be a potential predictor of neurocognitive injury for those patients. In the POCD group, the plasma Aβ levels after 24 h were significantly higher than those of pre-operative values (P
Li et al. / J Zhejiang Univ-Sci B (Biomed & Biotechnol) 2014 15(10):870-878
Journal of Zhejiang University-SCIENCE B (Biomedicine & Biotechnology) ISSN 1673-1581 (Print); ISSN 1862-1783 (Online) www.zju.edu.cn/jzus; www.springerlink.com E-mail: [email protected]
Relationship between post-operative cognitive dysfunction and regional cerebral oxygen saturation and β-amyloid protein* Xi-ming LI†§1,2, Ming-tao SHAO§3, Jian-juan WANG4, Yue-lan WANG†‡1 (1Department of Anesthesiology, Affiliated Qianfoshan Hospital of Shandong University, Jinan 250014, China) (2Department of Anesthesiology, Linyi City People's Hospital, Linyi 276000, China) 3
( Department of Emergency Surgery, Linyi City People's Hospital, Linyi 276000, China) 4
( Department of Anesthesiology, Shandong Lunan Ophthalmologic Hospital, Linyi 276000, China) †
E-mail: [email protected]; [email protected]
Received May 6, 2014; Revision accepted Aug. 7, 2014; Crosschecked Sept. 21, 2014
Abstract: Objective: To investigate the relationship between post-operative cognitive dysfunction (POCD) and regional cerebral oxygen saturation (rSO2) and β-amyloid protein (Aβ) in patients undergoing laparoscopic pancreaticoduodenectomy. Methods: Fifty patients undergoing elective laparoscopic pancreaticoduodenectomy received five groups of neuropsychological tests 1 d pre-operatively and 7 d post-operatively, with continuous monitoring of rSO2 intra-operatively. Before anesthesia induction (t0), at the beginning of laparoscopy (t1), and at the time of pneumoperitoneum 120 min (t2), pneumoperitoneum 240 min (t3), pneumoperitoneum 480 min (t4), the end of pneumoperitoneum (t5), and 24 h after surgery, jugular venous blood was drawn respectively for the measurement of Aβ by enzyme-linked immunosorbent assay (ELISA). Results: Twenty-one cases of the fifty patients suffered from POCD after operation. We found that the maximum percentage drop in rSO2 (rSO2, %max) was significantly higher in the POCD group than in the non-POCD group. The rSO2, %max value of over 10.2% might be a potential predictor of neurocognitive injury for those patients. In the POCD group, the plasma Aβ levels after 24 h were significantly higher than those of pre-operative values (P
