ORIGINAL ARTICLE

The Clinical Respiratory Journal Journal

Relationship between plasma chemerin levels and disease severity in COPD patients Banu Boyuk1, Eda C. Guzel2, Hande Atalay1, Savas Guzel3, Levent C. Mutlu4 and Volkan Kucukyalçin3 1 Department 2 Department 3 Department 4 Department

of of of of

Internal Medicine, Gaziosmanpasa Taksim Education and Research Hospital, Istanbul, Turkey Family Physician, Namik Kemal University Faculty of Medicine, Tekirdag, Turkey Biochemistry, Namik Kemal University Faculty of Medicine, Tekirdag, Turkey Pulmonary Medicine, Namik Kemal University Faculty of Medicine, Tekirdag, Turkey

Abstract Background and Aims: Chronic inflammation of the lung is a characteristic finding in chronic obstructive pulmonary disease (COPD). The protein chemerin has been identified in inflammatory fluid and in inflamed tissues. This study aimed to determine the association between serum chemerin levels and the severity of COPD. Methods: Forty-three COPD patients and 38 healthy subjects were enrolled in this study. Fasting plasma samples were obtained from the patient and the control group. Serum chemerin levels were measured using a commercial enzyme-linked immunosorbent assay. C-reactive protein levels, the erythrocyte sedimentation rate, and fibrinogen analysis were used to assess the inflammation status of the patients. Spirometric measurements with reversibility testing were performed in all the subjects. Results: Serum chemerin levels were significantly elevated in the COPD patients (6.44 ± 0.52 vs 5.22 ± 0.59; P < 0.001). A Mann–Whitney U-test revealed that the serum chemerin levels of stage 2 COPD patients were higher than those of stage 1 and 3 COPD patients (P = 0.651). Cigarette smoking and plasma chemerin relation was also understudied; however, there was no significant relationship between current smokers and ex-smokers (P > 0.05). Pearson’s correlation analysis indicated that serum chemerin levels were positively correlated only with total cholesterol (T. cholesterol) (P < 0.05, r = 0.382). In the linear regression analysis, chemerin levels were associated with age (β = 0.321), triglycerides (β = 0.299) and T. cholesterol (β = 0.555). Conclusion: Our study points to a relation between plasma chemerin levels and COPD. Larger patient groups are needed to verify the role of chemerin in the severity of COPD.

Please cite this paper as: Boyuk B, Guzel EC, Atalay H, Guzel Guzel S, S, Mutlu Mutlu LC LC and and Kucukyalc ¸in V. levels and and disease disease severity severity Kucukyalçin V. Relationship between plasma chemerin levels in COPD patients. DOI:10.1111/crj.12164. patients. Clin ClinRespir RespirJJ2015; 2014;9:••:468–474. ••–••. DOI:10.1111/crj.12164.

Introduction Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States, 468 The Clinical Respiratory Journal (2014) • ISSN 1752-6981 © 2014 John Wiley & Sons Ltd

Key words chemerin – cigarette – COPD – inflammation Correspondence Hande Atalay, MD, Department of Internal Medicine, Gaziosmanpasa Taksim Education and Research Hospital, Karayollari Mah., Osmanbey Cad., No:120, 34255 Istanbul, Turkey. Tel: +90-212-945-30-00 Fax: +90-212-945-31-80 email: [email protected] Received: 12 April 2013 Revision requested: 26 March 2014 Accepted: 16 May 2014 DOI:10.1111/crj.12164 Authorship and contributorship Designed the study: Boyuk B, Atalay H. Performed the study: Mutlu LC, Guzel EC. Analysed the data: Kucukyalçin V, Guzel S. Wrote the paper: Boyuk B, Atalay H. Ethics The study protocol was approved by Bakirkoy Sadi Konuk Research Hospital Ethics Committee, Istanbul. Informed written consent was obtained from all the participants (COPD patients and controls) after a full explanation about the study and its purpose. Conflict of interest The authors have stated explicitly that there are no conflicts of interest in connection with this article.

and COPD-related mortality is rising (1). In Turkey, it was the same in a study which was headed by the Turkish health ministry by using global burden of study method in 2004 (2, 3). COPD is defined

The Clinical Respiratory Journal (2015) • ISSN 1752-6981 1 C 2014 John Wiley & Sons Ltd V

Boyuk et al.and disease severity in COPD Chemerin

as a post bronchodilator fixed ratio of

Relationship between plasma chemerin levels and disease severity in COPD patients.

Chronic inflammation of the lung is a characteristic finding in chronic obstructive pulmonary disease (COPD). The protein chemerin has been identified...
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