Biol. Neonate 35 : 60-65 (1979)

Relationship between Maturity, Electrolyte Balance and the Function of the Renin-Angiotensin-Aldosterone System in Newborn Infants E. Sulyok, M. Nemeth, I. Tenyi, I.F. Csaba, F. Varga, E. Gyory and V. Thurzo Department of Obstetrics and Gynecology, and 1st Department of Medicine, University of Pecs, Pecs

Key Words. Plasma renin activity • Plasma aldosterone • Aldosterone excretion • Maturity • Electrolyte balance

Introduction

In recent years, there have been several reports on neonatal hyperfunction of the reninangiotensin-aldosterone system (RAAS). It has been demonstrated that plasma renin activity (PRA) (7, 8, 11, 13, 15, 17, 25), plasma

angiotensin (3 ,4 , 8, 15, 17) and plasma aldoste­ rone cor.centration (PA) (2, 7, 8, 13, 19, 23, 25) are higher in newborn infants than in normal adults. Although several factors have been considered which may be responsible for the increased activity of the RAAS, the reason for this increase is not apparent and its patho-

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Abstract. Simultaneous measurement of plasma renin activity (PRA), plasma aldosterone concentration (PA) and urinary aldosterone excretion (UAE) was made using the RIA method along with determination of Na and K balance in 1-week-old neonates with gestational age of 30—41 weeks (mean 35.9 weeks) and birth weight of 1,160-4,670 g (mean 2,680 g). It was demonstrated that PRA decreased from the value of 36.3 ± 6.3 ng/ml/h (mean ± SE) to a level of 10.2 ± 2.1 ng/ml/h (p

Relationship between maturity, electrolyte balance and the function of the renin-angiotensin-aldosterone system in newborn infants.

Biol. Neonate 35 : 60-65 (1979) Relationship between Maturity, Electrolyte Balance and the Function of the Renin-Angiotensin-Aldosterone System in Ne...
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