ORIGINAL ARTICLE
Relationship between apathy and cognitive dysfunctions in de novo untreated Parkinson’s disease: a prospective longitudinal study G. Santangeloa,b, C. Vitaleb,c, L. Trojanoa, M. Picillod, M. Mocciad, G. Pisanoa, D. Pezzellaa, S. Cuocoa, R. Errod, K. Longob, M. T. Pellecchiae, M. Ambonib, A. De Rosad, G. De Micheled and P. Baronee Department of Psychology, Second University of Naples, Caserta; bIDC-Hermitage-Capodimonte, Naples; cUniversity Parthenope, Naples; dDepartment of Neurological Sciences, University Federico II, Naples; and eNeurodegenerative Diseases Center, Department of Medicine and Surgery, University of Salerno, Salerno, Italy
See editorial by Benoit on page 221.
Keywords:
apathy, behavioral disorders, cognitive dysfunctions, frontal dysfunctions, Parkinson’s disease Received 23 November 2013 Accepted 26 March 2014 European Journal of Neurology 2015, 22: 253–260 doi:10.1111/ene.12467
Background and purpose: Apathy may be either a symptom of major depression or a behavioral disturbance occurring in concomitance with depression or alone in Parkinson’s disease (PD). The aim of the present study was to determine the progression of cognitive impairment in drug-na€ıve untreated PD patients with or without clinically significant apathy. Methods: Sixty-two PD patients with a disease duration
Relationship between apathy and cognitive dysfunctions in de novo untreated Parkinson’s disease: a prospective longitudinal study G. Santangeloa,b, C. Vitaleb,c, L. Trojanoa, M. Picillod, M. Mocciad, G. Pisanoa, D. Pezzellaa, S. Cuocoa, R. Errod, K. Longob, M. T. Pellecchiae, M. Ambonib, A. De Rosad, G. De Micheled and P. Baronee Department of Psychology, Second University of Naples, Caserta; bIDC-Hermitage-Capodimonte, Naples; cUniversity Parthenope, Naples; dDepartment of Neurological Sciences, University Federico II, Naples; and eNeurodegenerative Diseases Center, Department of Medicine and Surgery, University of Salerno, Salerno, Italy
See editorial by Benoit on page 221.
Keywords:
apathy, behavioral disorders, cognitive dysfunctions, frontal dysfunctions, Parkinson’s disease Received 23 November 2013 Accepted 26 March 2014 European Journal of Neurology 2015, 22: 253–260 doi:10.1111/ene.12467
Background and purpose: Apathy may be either a symptom of major depression or a behavioral disturbance occurring in concomitance with depression or alone in Parkinson’s disease (PD). The aim of the present study was to determine the progression of cognitive impairment in drug-na€ıve untreated PD patients with or without clinically significant apathy. Methods: Sixty-two PD patients with a disease duration
