Cerebral Cortex, March 2016;26: 1322–1335 doi: 10.1093/cercor/bhv305 Advance Access Publication Date: 7 January 2016 Original Article

ORIGINAL ARTICLE

Reinforcement of the Brain’s Rich-Club Architecture Following Early Neurodevelopmental Disruption Caused by Very Preterm Birth Vyacheslav R. Karolis1, Sean Froudist-Walsh1, Philip J. Brittain1, Jasmin Kroll1, Gareth Ball2, A. David Edwards2, Flavio Dell’Acqua3, Steven C. Williams3, Robin M. Murray1 and Chiara Nosarti1,2 1

Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, 2Centre for the Developing Brain, Division of Imaging Sciences & Biomedical Engineering and 3Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, London, UK Address correspondence to Dr Vyacheslav R. Karolis, Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King’s College London, 16 De Crispigny Park, London SE5 8AF, UK. Email: [email protected]

Abstract The second half of pregnancy is a crucial period for the development of structural brain connectivity, and an abrupt interruption of the typical processes of development during this phase caused by the very preterm birth (