Original Article

Reduction of Interhemispheric Functional Connectivity in Sensorimotor and Visual Information Processing Pathways in Schizophrenia Xu Lang1, Le Wang2, Chuan‑Jun Zhuo3,4, Feng Jia4, Li‑Na Wang4, Chun‑Li Wang4 1

Department of Radiology and Tianjin Key Laboratory of Functional Imaging, Tianjin Medical University General Hospital, Tianjin 300052, China 2 Department of Radiology, First Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi 030001, China 3 Tianjin Anning Hospital, Tianjin 300300, China 4 Tianjin Mental Health Center, Tianjin Anding Hospital, Tianjin 300070, China Xu Lang and Le Wang contributed equally to this work.

Abstract Background: Previous studies have demonstrated interhemispheric functional connectivity alterations in schizophrenia. However, the relationship between these alterations and the disease state of schizophrenia is largely unknown. Therefore, we aimed to investigate this relationship using voxel‑mirrored homotopic connectivity (VMHC) method. Methods: This study enrolled 36 schizophrenia patients with complete remission, 58 schizophrenia patients with incomplete remission and 55 healthy controls. The VMHC was calculated based on resting‑state functional magnetic resonance imaging data. Differences in VMHC among three groups were compared using one‑way analysis of variance. A brain region with a significant difference in VMHC was defined as a region of interest (ROI), and the mean VMHC value in the ROI was extracted for the post hoc analysis, i.e., pair‑wise comparisons across the three groups. Results: VMHC in the visual region (inferior occipital and fusiform gyri) and the sensorimotor region (paracentral lobule) showed significant differences among the three groups (P 

Reduction of Interhemispheric Functional Connectivity in Sensorimotor and Visual Information Processing Pathways in Schizophrenia.

Previous studies have demonstrated interhemispheric functional connectivity alterations in schizophrenia. However, the relationship between these alte...
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