Europace Advance Access published February 18, 2015

CLINICAL RESEARCH

Europace doi:10.1093/europace/euu389

Recurrence of paroxysmal atrial fibrillation after pulmonary vein isolation: is repeat pulmonary vein isolation enough? A prospective, randomized trial Stephanie Fichtner 1,*, Korbinian Sparn2, Tilko Reents 2, Sonia Ammar2, Verena Semmler 2, Roger Dillier 2, Alexandra Buiatti2, Susanne Kathan 2, Gabriele Hessling 2, and Isabel Deisenhofer 2 1

Medizinische Klinik I, Klinikum der Universita¨t Mu¨nchen, Marchioninistr. 15, Munich 81377, Germany; and 2Deutsches Herzzentrum Mu¨nchen, Lazarettstr. 36, Munich 80636, Germany

Received 20 October 2014; accepted after revision 10 December 2014

Aims

----------------------------------------------------------------------------------------------------------------------------------------------------------Keywords

Atrial fibrillation † Relapse; † Pulmonary vein isolation † Anterior line † PVI

Introduction Pulmonary vein isolation (PVI) has become a widely used and accepted treatment option in patients with paroxysmal atrial fibrillation (AF) with single procedure success rates of 60–80%.1 – 3 Although treatment expertise and technical equipment improve, about 30% of patients undergo a repeat ablation procedure because of arrhythmia recurrence.2,4,5 Pulmonary vein (PV) reconnection (detected in the majority of PVs during the repeat ablation) is suggested to be the main cause of arrhythmia recurrence.6 – 9 Another hypothesis is a progression of the atrial substrate and/or a higher percentage of extra PV foci in patients with AF recurrence. From experience with the surgical maze procedure, the addition of linear lesions to PVI has been

suggested to modify the substrate for AF and improve clinical outcomes.10 Therefore, the question arises whether patients would profit from a more extensive ablation approach during the repeat procedure. As up to now no prospective randomized trial has dealt with the optimal treatment strategy for the repeat ablation procedure in patients with recurrent paroxysmal AF after PVI, we compared a repeat PVI with a PVI and a left atrial line (AL).

Methods Patients This single-centre prospective randomized trial was performed at the German Heart Center in Munich, Germany, and was accepted by the

* Corresponding author. Tel: +49 89 4400 73034; fax: +49 89 4400 78797, E-mail address: [email protected] Published on behalf of the European Society of Cardiology. All rights reserved. & The Author 2015. For permissions please email: [email protected].

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In patients with paroxysmal atrial fibrillation (pAF), pulmonary vein isolation (PVI) has become an accepted treatment option with single procedure success rates of 60– 80%. A repeat ablation is performed in 30% of patients because of arrhythmia recurrence. The strategy for this repeat procedure is not defined. ..................................................................................................................................................................................... Methods Patients with pAF recurrence after PVI were prospectively randomized and underwent a second ablation procedure with and results either PVI of all reconnected veins or PVI with an additional left atrial anterior line. Follow-up in our arrhythmia clinic was every 3 months up to 12 months including 7 day Holter monitoring. A total of 77 patients (mean age 63 + 9 years, 69% males) were included in the analysis. A repeat PVI was performed in 41 patients, PVI + anterior line in 36 patients. After a follow-up of 12 months, 26 of 41 (63%) patients after repeat PVI and 18 of 36 (50%) patients with PVI + anterior line were in stable sinus rhythm off antiarrhythmic medication (P ¼ 0.26). In most patients (12 of 15 patients with PVI and 14 of 18 patients with PVI + anterior line) with an arrhythmia recurrence after the second procedure, the recurring arrhythmia was paroxysmal AF. In 2 of 15 patients of the PVI group and in 4 of 18 patients of the PVI + anterior line group atypical flutter was the reoccurring arrhythmia (P ¼ NS). ..................................................................................................................................................................................... Conclusion In this prospective randomized trial, patients with a recurrence of paroxysmal AF had no better outcome after repeat PVI + one left atrial line compared with patients with repeat PVI only.

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S. Fichtner et al.

What’s new? † Randomized prospective trial solely in patients with relapse of paroxysmal atrial fibrillation (AF) after initial pulmonary vein isolation (PVI) for paroxysmal AF † Randomized to repeat PVI or repeat PVI and anterior line

local ethic committee (clinical trial.gov identifier: NCT01229306). Patients were eligible if they had a documented relapse of paroxysmal AF and had previously undergone PVI for paroxysmal AF. Patients with persistent AF or atrial tachycardia were excluded. All patients were randomized using randomization envelopes either to the repeat PVI group or to the group with repeat PVI plus an additional left AL. Patients were recruited from July 2010 until October 2012. † Primary endpoint: Freedom from atrial arrhythmias after 12 months off antiarrhythmic medication † Secondary endpoint: reconnected PVs, type of arrhythmia recurrence after repeat procedure, adverse events.

Procedure

Reisolation of all reconnected pulmonary veins Pulmonary vein isolation was performed using a circular steerable mapping catheter (LassoTM , Biosense-Webster or Orbiter PVTM , C.R: Bard) and an irrigated tip ablation catheter (Celsius ThermocoolTM , Biosense Webster, or Therapy Cool PathTM , St. Jude). If PVs showed

Reisolation of all reconnected pulmonary veins plus additional anterior line Initially all reconnected PVs were circumferentially re-isolated. In addition, a left AL from the anterior mitral annulus to the left superior pulmonary vein was drawn as described earlier (see Figure 1).11 This was performed under continuous pacing from the left atrial appendage. Bidirektional block was tested using differential pacing criteria and the line was tested for double potentials (for further information see ref 11).

Follow-up after ablation Patients were scheduled for visits at the arrhythmia clinic 3, 6, and 12 months after the procedure. At each visit, intensive questioning for arrhythmia-related symptoms was done and in all patients 7 day Holter electrocardiogram was performed at each visit. A blanking period of 6 weeks was used and any documented atrial arrhythmia occurring after the blanking period and lasting .30 s were counted as arrhythmia recurrence. If no AF recurrence was detected within the first 6 months and the CHA2DS2 Vasc score was ≤2, oral anticoagulation was discontinued. No antiarrhythmic medication besides beta blockers was prescribed after the ablation procedure.

Statistical analysis All values are presented as mean + SD. Student’s t-test, Fisher’s exact test, Wilcoxon’s test, and x2 test were applied for comparisons. A probability value of P , 0.05 was considered statistically significant.

Results Patient characteristics A total of 77 patients with relapse of paroxysmal atrial fibrillation were included in the study; 41 patients in the PVI group, 36 in the

R R

Figure 1 Group 1 underwent repeat PVI (left picture), group 2 underwent repeat PVI plus additional left atrial line from mitral annulus to the left superior vein (right picture).

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Patients were kept on continuous oral anticoagulation with intraprocedural INR levels of 2.0– 2.7 or continued taking Dabigatran. Ablation procedures were performed under conscious sedation using a threedimensional mapping system for anatomy and catheter visualization (Carto 3, Biosense-Webster or Ensite Navx, St. Jude Medical). The individual left atrial anatomy as segmented from the previous computed tomographic scan was displayed during the procedure and fused with the reconstructed anatomy in the three-dimensional mapping system if felt appropriate. An 8 polar catheter was placed in the coronary sinus (CS; XPT, C.R. Bard) and the left atrium (LA) was accessed by single or double transseptal puncture or via an open foramen ovale. Preablation and postablation angiograms of all PVs were performed. After placement of electrode catheters within the LA, heparin was given to maintain an activated clotting time at ≥270 s.

reconnection, a complete circumferential approach isolating all reconnected PVs was used (see Figure 1), even if only a single gab was seen. The circular mapping catheter was positioned as close to the pulmonary vein ostium as possible. Circular mapping was performed by obtaining 10 bipolar electrograms (1 to 2, 2 to 3, up to 10 to 1 electrode pairs) from the circularly arranged electrodes. Pulmonary vein isolation was performed by applying radiofrequency (RF) current at the antral sites. At the end of the procedure, entry and exit block of all PVs was documented.

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Recurrence of paroxysmal atrial fibrillation after PVI

PVI + AL group. Baseline characteristics in both groups were comparable (see Table 1). Patients’ age was 64 + 9 years (PVI group) and 62 + 8 years (PVI + AL group). Paroxysmal AF was present since 74.5 + 76 (PVI) and 97.3 + 80 (PVI + AL) months, respectively. The initial PVI procedure had taken place 21.5 + 27.6 (PVI) and 17.3 + 24.7 (PVI + AL) months before the repeat procedure. The cardiovascular risk factors were equally distributed in both groups (see Table 1).

Procedural results

PVI 1 anterior line

PVI

P value

................................................................................ 3.7 + 0.9

3.3 + 0.9

106.6 + 42

117.9 + 52

Reconnected PV per patient Procedure time (min)

0.02 0.3

RF time (min)

33.5 + 18

44.7 + 19

0.01

Fluoroscopy time (min)

21.8 + 14

16.9 + 13.5

0.14

1557 + 1203

0.35

Fluoroscopy dose (cGym)

1818 + 1219

Tamponade Procedural stroke

0 0

0 0

1.0 1.0

Blood transfusion

0

0

1.0

Groin pseudoaneurysm

1

0

1.0

70

P = 0.26

60 50

Primary endpoint outcome

40

After 12 months follow-up, stable sinus rhythm off antiarrhythmic medication was present in 63% of patients in the PVI group and 50% of patients in the PVI + AL group (P ¼ 0.26) (Figure 2). Patients with arrhythmia recurrence after the repeat ablation procedure had paroxysmal AF in most cases in both groups (75% vs. 78%). Atypical atrial flutter occurred in four patients in the

30 20 10 0 PVI only

PVI + anterior line

Figure 2 After a follow-up of 12 months 63% in the PVI only group and 50% in the PVI + anterior line group were in stable sinus rhythm off antiarrhythmic medication.

Table 1 Baseline characteristics PVI (n 5 41)

PVI 1 anterior line (n 5 36)

P value

Age Gender (male)

64 + 9 68%

62 + 8 69%

0.33 1.0

Duration of atrial fibrillation (months)

74.5 + 76

97.3 + 80

0.25

Time since initial PVI (months)

21.5 + 27.6

................................................................................

2

17.3 + 24.7

Table 3 Type of arrhythmia recurrence after repeat procedure PVI (N 5 16)

PVI 1 anterior line (N 5 18)

P value

0.4

0.5

............................................................................... Paroxysmal AF Persistent AF

75% 12.5%

78% 0%

Atypical flutter

12.5%

22%

CHADS VASc score

2.3 + 1.7

2.1 + 1.8

0.62

Art. hypertension Hyperlipidemia

71% 39%

61% 61%

0.47 0.07

Coronary artery disease

14.6%

8.3%

0.5

Diabetes mellitus

12%

8.3%

0.7

Previous stroke Size of left atrium

7.3% 44 + 6.2

16.7% 43.7 + 5

0.3 0.85

PVI + AL group and in two patients in the PVI group (see Table 3). In two of the four patients with atypical flutter of the PVI + AL group perimitral flutter was the reason and could be terminated by closing the gap in the ablation line.

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In all patients repeat PVI was performed successfully and 100% of reconnected PVs were isolated. In all patients of the PVI + AL group, the AL was successfully applied and bidirectional block confirmed. Reconnected atrio-PV conduction was present in 3.7 + 0.9 of PVs in the PVI group and 3.3 + 0.9 in the PVI + AL group (P ¼ 0.02). Procedure time was comparable with 106.6 min in the PVI group and 117.9 min in the PVI + AL group (P ¼ 0.3). Radiofrequency time was significantly higher in the PVI + AL group compared with the PVI group (44.7 + 19 vs. 33.5 + 18, P ¼ 0.01). Fluoroscopic time and dose showed no significant differences [fluoroscopic time 21.8 + 14 (PVI) vs. 16.9 + 13.5 (PVI + AL) and fluoroscopic dose 1818 + 1219 (PVI) vs. 1557 + 1203 (PVI + AL)] (Table 2). No serious adverse events were observed. A groin pseudoaneurysm in the PVI group was managed without surgical intervention.

Table 2 Procedural data

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Discussion Main findings In this prospective randomized trial, patients with recurrent paroxysmal AF after PVI did not profit from a more extensive reablation approach including PVI and a left anterior line compared with patients who underwent repeat PVI only.

Pulmonary vein isolation and substrate modification in patients with paroxysmal atrial fibrillation

Success after repeat ablation procedure To our knowledge, there is only one prospective clinical trial that only included patients with arrhythmia recurrence after PVI using cryoballon. In this trial, patients with arrhythmia relapse were randomized to repeat PVI using cryoballon vs. repeat PVI using RF. In the group using RF for repeat PVI a higher rate of freedom from AF was observed (58% vs. 43%, P ¼ 0.06).21 In our study, stable sinus rhythm after 12 months off antiarrhythmic medication was reached in 63% vs. 50% of patients leading to the assumption that patients who need a repeat procedure are more difficult to treat.

Type of arrhythmia recurrence after the repeat ablation Patients who had arrhythmia relapse after the repeat ablation procedure presented with paroxysmal AF in the majority of cases; only a minority of patients developed atypical atrial flutter in both groups. In the study by Sawhney et al.,18 significant more atypical flutter was detected in patients with an additional AL; however, in this study two AL s (mitral isthmus line and roof line) were done that might lead to a higher risk of gaps in the lines.

Limitations This is a single-centre study only with a limited number of patients; therefore significant differences might have been missed.

Conclusion In this prospective randomized trial, patients with recurrent paroxysmal AF after PVI had no better outcome (sinus rhythm off antiarrhythmic medication) after a repeat PVI + one left AL compared with patients who underwent a repeat PVI only. Conflict of interest: none declared.

Funding No external funding was received, only through the German heart center.

References 1. Calkins H, Brugada J, Packer DL, Cappato R, Chen SA, Crijns HJ et al. HRS/EHRA/ ECAS expert consensus statement on catheter and surgical ablation of atrial fibrillation: recommendations for personnel, policy, procedures and follow-up. A report of the Heart Rhythm Society (HRS) Task Force on Catheter and Surgical Ablation of Atrial Fibrillation developed in partnership with the European Heart Rhythm Association (EHRA) and the European Cardiac Arrhythmia Society (ECAS). Europace 2007;9:335 –79. 2. Calkins H, Kuck KH, Cappato R, Brugada J, Camm AJ, Chen SA et al. 2012 HRS/ EHRA/ECAS Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation: recommendations for patient selection, procedural techniques, patient management and follow-up, definitions, endpoints, and research trial design. Europace 2012;14:528 –606. 3. Camm AJ, Lip GY, De Caterina R, Savelieva I, Atar D, Hohnloser SH et al. 2012 focused update of the ESC Guidelines for the management of atrial fibrillation: an update of the 2010 ESC Guidelines for the management of atrial fibrillation. Developed with the special contribution of the European Heart Rhythm Association. Europace 2012;14:1385 –413. 4. Bhargava M, Di Biase L, Mohanty P, Prasad S, Martin DO, Williams-Andrews M et al. Impact of type of atrial fibrillation and repeat catheter ablation on long-term freedom from atrial fibrillation: Results from a multicenter study. Heart Rhythm 2009;6:1403–12. 5. Miyazaki S, Kuwahara T, Kobori A, Takahashi Y, Takei A, Sato A et al. Long-term clinical outcome of extensive pulmonary vein isolation-based catheter ablation therapy in patients with paroxysmal and persistent atrial fibrillation. Heart 2011;97:668 –73. 6. Fiala M, Chovancik J, Nevralova˜ Rt, Neuwirth R, Jiravsky O, Nykl I et al. Pulmonary vein isolation using segmental versus electroanatomical circumferential ablation for paroxysmal atrial fibrillation. J Interv Cardiac Electrophysiol 2008;22:13 –21. 7. Fichtner S, Czudnochowsky U, Hessling G, Reents T, Estner H, Wu J et al. Very late relapse of atrial fibrillation after pulmonary vein isolation: incidence and results of repeat ablation. Pacing Clin Electrophysiol 2010;33:1258 –63. 8. Nilsson B, Chen X, Pehrson S, Kober L, Hilden J, Svendsen JH. Recurrence of pulmonary vein conduction and atrial fibrillation after pulmonary vein isolation for atrial fibrillation: a randomized trial of the ostial versus the extraostial ablation strategy. Am Heart J 2006;152:537 e1-8. 9. Cappato R, Negroni S, Pecora D, Bentivegna S, Lupo PP, Carolei A et al. Prospective assessment of late conduction recurrence across radiofrequency lesions producing electrical disconnection at the pulmonary vein ostium in patients with atrial fibrillation. Circulation 2003;108:1599 –604.

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There are reports that in patients with paroxysmal AF, a substrate modification ablating complex atrial fractionated electrograms (CFAEs) showed no additional benefit to PVI only.12 However, in patients with persistent AF, adding CFAE ablation to PVI improved the success rates significantly.12 – 15 Additional isolation of the vena cava superior and the coronary sinus in patients with paroxysmal AF and PVI did also not show a significant improvement compared with PVI alone.16,17 In another study, patients with paroxysmal AF were randomized to PVI alone or PVI plus roof line and mitral isthmus line during the initial ablation. No significant difference was found after 16 months of follow-up with regard to sinus rhythm off antiarrhythmic medication. However, patients in the PVI plus line group showed significantly more often left atrial atypical flutter as reoccurring arrhythmia.18 Another study could also show no additional benefit in patients with initially PVI plus lines.19 However, patients treated with lines according to the maze procedure had an improved outcome compared with patients with single PVI regardless of the type of AF.10 To our knowledge, no study investigated patients with paroxysmal AF relapse after PVI adding substrate modification to the repeat PVI. It is well known that about 30% of patients after PVI need a repeat procedure because of arrhythmia recurrence.2,4,5 From these studies, the assumption arises that atrio-PV reconnection is the main cause of arrhythmia recurrence.8,9 However, in patients with persistent AF, PVI alone leads to worse success compared with PVI plus substrate modification.14,20 It might be speculated that at least a part of patients with paroxysmal AF relapse after PVI already have a more advanced level of atrial disease and might benefit from substrate modification and as could be shown in multiple maze studies lines do alter the substrate. This could not be demonstrated in our study. The rate of reconnected PVs was high in both groups and the additional AL from the mitral annulus to the left superior pulmonary vein did not improve outcome which emphasizes the role of reconnected PVs as the leading cause of arrhythmia recurrence.

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Recurrence of paroxysmal atrial fibrillation after PVI

10. Stulak JM, Dearani JA, Sundt TM 3rd, Daly RC, Schaff HV. Ablation of atrial fibrillation: comparison of catheter-based techniques and the Cox-Maze III operation. Ann Thorac Surg 2011;91:1882 –8; discussion 88-9. 11. Tzeis S, Luik A, Jilek C, Schmitt C, Estner HL, Wu J et al. The modified anterior line: an alternative linear lesion in perimitral flutter. J Cardiovasc Electrophysiol 2010;21: 665 –70. 12. Deisenhofer I, Estner H, Reents T, Fichtner S, Bauer A, Wu J et al. Does electrogram guided substrate ablation add to the success of pulmonary vein isolation in patients with paroxysmal atrial fibrillation? A prospective, randomized study. J Cardiovasc Electrophysiol 2009;20:514 – 21. 13. Wu SH, Jiang WF, Gu J, Zhao L, Wang YL, Liu YG et al. Benefits and risks of additional ablation of complex fractionated atrial electrograms for patients with atrial fibrillation: a systematic review and meta-analysis. Int J Cardiol 2013;169: 35 – 43. 14. Hayward RM, Upadhyay GA, Mela T, Ellinor PT, Barrett CD, Heist EK et al. Pulmonary vein isolation with complex fractionated atrial electrogram ablation for paroxysmal and nonparoxysmal atrial fibrillation: A meta-analysis. Heart Rhythm 2011;8: 994 –1000. 15. Li WJ, Bai YY, Zhang HY, Tang RB, Miao CL, Sang CH et al. Additional ablation of complex fractionated atrial electrograms after pulmonary vein isolation in patients with atrial fibrillation: a meta-analysis. Circ Arrhythmia Electrophysiol 2011;4:143 –8.

Page 5 of 5 16. Wang XH, Liu X, Sun YM, Shi HF, Zhou L, Gu JN. Pulmonary vein isolation combined with superior vena cava isolation for atrial fibrillation ablation: a prospective randomized study. Europace 2008;10:600 – 5. 17. Gavin AR, Singleton CB, Bowyer J, McGavigan AD. Pulmonary venous isolation versus additional substrate modification as treatment for paroxysmal atrial fibrillation. J Interv Cardiac Electrophysiol 2011;33:101 –7. 18. Sawhney N, Anousheh R, Chen W, Feld GK. Circumferential pulmonary vein ablation with additional linear ablation results in an increased incidence of left atrial flutter compared with segmental pulmonary vein isolation as an initial approach to ablation of paroxysmal atrial fibrillation. Circ Arrhythmia Electrophysiol 2010;3:243 –8. 19. Kim TH, Park J, Park JK, Uhm JS, Joung B, Hwang C et al. Linear ablation in addition to circumferential pulmonary vein isolation (Dallas lesion set) does not improve clinical outcome in patients with paroxysmal atrial fibrillation: a prospective randomized study. Europace 2014; doi:10.1093/europace/euu245. 20. Ammar S, Hessling G, Reents T, Fichtner S, Wu J, Zhu P et al. Arrhythmia type after persistent atrial fibrillation ablation predicts success of the repeat procedure. Circ Arrhythmia Electrophysiol 2011;4:609 – 14. 21. Pokushalov E, Romanov A, Artyomenko S, Baranova V, Losik D, Bairamova S et al. Cryoballoon versus radiofrequency for pulmonary vein re-isolation after a failed initial ablation procedure in patients with paroxysmal atrial fibrillation. J Cardiovasc Electrophysiol 2013;24:274–9.

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Recurrence of paroxysmal atrial fibrillation after pulmonary vein isolation: is repeat pulmonary vein isolation enough? A prospective, randomized trial.

In patients with paroxysmal atrial fibrillation (pAF), pulmonary vein isolation (PVI) has become an accepted treatment option with single procedure su...
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