1368

36. Somers VK, Conway

J, Sleight P. The effect of physical training on home blood pressure measurement in normal subjects. J Hypertens 1986; 4 (suppl 6): S657-58. 37. Rose C. Strategy of prevention: lessons from cardiovascular disease. Br Med J 1981; 282: 1847-51. 38. Sedgwick AW, Craig RJ, Crouch R, Dowling B. The effects of physical training on the day and night long-term heart rate of middle-aged men. Eur J Appl Physiol 1974; 33: 307-14. 39. Lewis S, Thompson P, Areskog N-H, et al. Endurance training and heart rate control studied by combined parasympathetic and &bgr;-adrenergic blockade. Int J Sports Med 1980; 1: 42-49.

Millar JA. Hypertension in children. Br Med J 1985; 290: 1451-52. 41. Mark AL, Kerber RE. Augmentation of cardiopulmonary baroreflex control of forearm vascular resistance in borderline hypertension. Hypertension 1982; 4: 39-46. 42. Radice M, Alberti D, Alli F, et al. Blood pressure response to dynamic exercise in adolescents with different risks of developing hypertension (in Italian). Boll Soc Ital 1984; 29: 519-22. 43. Somers VK, Mark AL, Abboud FM. Potentiation of sympathetic nerve responses to hypoxia in borderline hypertensive subjects. Hypertension 1988; 11: 608-12. 40.

Isley CD,

Recognition of human 60 kD heat shock protein by mononuclear cells from patients with juvenile chronic arthritis

A postulated mechanism for autoimmune disorders is that the immunoreactivity develops against bacterial antigens which show a high degree of sequence homology with mammalian proteins. The mycobacterial 65 kD heat shock protein (hsp) has been implicated in several forms of arthritis. Substantial amounts of the human 60 kD homologue (hsp60) were produced by insertion of the gene into Escherichia coli. To investigate the hypothesis that T-cell reactivity is directed against the endogenous hsp, T-cell proliferation of synovialfluid and peripheral-blood mononuclear cells in response to hsp60 was studied in samples from six patients with juvenile chronic arthritis (JCA) and nine adult patients with rheumatoid arthritis (RA). There was no T-lymphocyte proliferative response to purified fractions of hsp60 in mononuclear cells from RA patients or healthy children and young adults. However, both synovial-fluid and peripheral-blood mononuclear cells from JCA patients showed substantial proliferative responses. There was a significant correlation between the stimulation indices for human hsp60 and for mycobacterial hsp65 (r = 0·948, p

Recognition of human 60 kD heat shock protein by mononuclear cells from patients with juvenile chronic arthritis.

A postulated mechanism for autoimmune disorders is that the immunoreactivity develops against bacterial antigens which show a high degree of sequence ...
742KB Sizes 0 Downloads 0 Views