European Journal of Neurology 2014, 21: 1425–1434



Recent advances in neurology 2013–2014

The advent of modern neuro-imaging modalities transformed the practice of neurology and neurosurgery. Advances in this area continue with increased resolution and three-dimensional reconstructions, but perhaps the most exciting area of neuroradiology is the application of radiotracers or receptor ligands to the diagnosis of neurological diseases. The areas of stroke and the neurodegenerative diseases have perhaps been those that have benefited most from the new imaging modalities, but inflammatory disorders and common clinical problems such as headache have also seen novel applications. Probably the next most important area for advance and clinical application has been in the field of molecular neuroscience and genetics in particular. The ability to identify the genetic basis of disease has transformed the way we recognize the spectrum of the clinical phenotype of a particular mutation; indeed this has led us to reconsider the criteria for diagnosis in certain diseases such as Parkinson’s disease. These advances have also provided invaluable insight into the pathogenesis of neurological diseases and potential targets for novel therapeutic interventions. The past year has seen these advances reflected in the number and range of articles published in the European Journal of Neurology. Again, stroke is the most active area for publication followed by Parkinson’s disease and other movement disorders. The pathophysiology of stroke [1–22] has seen advances in the genetics of stroke that include identification of a single gene but more frequently multiple gene associations that confer increased risk. The observation that vitamin D levels can be associated with stroke risk is interesting, bearing in mind that levels have also been associated with the risk for Parkinson’s disease and multiple sclerosis. The management of acute stroke [23–38] is focused on intravascular thrombolysis, now with a longer time window for intervention but with diminishing returns in terms of improved outcome. The management of blood glucose and blood pressure remain of importance in the acute stage as well as in prevention and post-stroke management. The treatment and prevention of stroke [39–47] to improve outcomes [48–72] has as much to do with therapeutic intervention as it has to do with education of the general public as well as physicians. The swift recognition of transient ischaemic attacks and stroke is essential to improve outcome. The identification and correct stratification

© 2014 EAN

for treatment of patients with atrial fibrillation is a major feature of stroke prevention. Multiple sclerosis [73–101] is considered the prototypic neuro-inflammatory disease. It is now recognized to have a significant genetic component, although no single gene mutations have been identified, so again this is likely to be a complex genetic influence on risk. Other insights into pathogenesis include the role of axonal degeneration and the possible contribution of mitochondrial dysfunction. Disease-modifying therapies have had a significant impact upon relapse rate and outcome but are not without adverse events. Attempts to stratify patients manifesting with a single episode of demyelination into prognostic groups may enable the identification of those patients who might benefit more from earlier as opposed to later intervention with these drugs. Our understanding of the cause and pathophysiology of Parkinson’s disease (PD) [102–123] has benefited considerably from the molecular and imaging advances referred to above. Several monogenetic forms of PD are recognized, and recent genome-wide association studies have confirmed alpha-synuclein, tau, immune pathway and glucocerebrosidase (GBA) genes as playing important roles in determining risk. GBA gene mutations are now recognized as numerically the most important risk factor for PD. Studies have confirmed this in several ethnic groups, although the prevalence of GBA mutations varies between groups, being most common in the Ashkenazi population. Attention is focused on the prodromal period of PD where subtle clinical abnormalities, e.g. hyposmia, rapid eye movement sleep behaviour, can precede the onset of motor problems by several years. It is hoped that a combination of genetic, clinical and biochemical biomarkers may offer clinicians the opportunity to identify those most at risk for PD and therefore those most suitable for early intervention with a diseasemodifying drug, should one become available. Novel imaging modalities to detect microglial activation and alpha-synuclein offer benefits for early detection, but in particular a means potentially to follow the course of the disease and the success or not of therapies to slow progression. Advances in the clinical prodrome and pathogenesis of PD have called into question the traditional clinically based diagnosis of PD. Guidelines on the diagnosis of PD provide a rational basis for diagnosis [102], and for practical clinical practice the clinically



based diagnosis of PD remains intact. The symptomatic treatment of PD over the past year has been refined rather than revolutionized. Dopamine agonists are now available as once-a-day treatments and have a similar efficacy and adverse event profile to the traditional shorter acting preparations. However, it is clear that patients prefer the convenience of once-aday medication. The European Federation of Neurological Societies guidelines on the treatment of PD provide an excellent evidence-based review [105]. However, the recognition and treatment of non-motor symptoms remain a major unmet need for PD patients [124–132]. Although traditionally associated with features such as cognitive abnormalities, autonomic dysfunction etc., sleep disorders and pain are commonly recognized problems; the latter may be exacerbated by dopaminergic medication. Unfortunately, effective treatments for non-motor symptoms are very limited. Movement disorders other than PD have also benefited from the major developments in genetics and imaging [133–147]. Huntington’s disease is a good example where the use of longitudinal magnetic resonance imaging can follow progression in pre-symptomatic mutation carriers and potentially be used as a marker for efficacy of disease-modifying interventions. Imaging can also be helpful to distinguish some forms of parkinsonism although not necessarily with great sensitivity. Genetics has enabled the identification of several novel parkinsonism dystonia syndromes and has also opened up the essential tremor and dystonia fields [148–153]. The main focus of attention for Alzheimer’s disease and other dementias [154–163] remains the discovery of an intervention that will slow or prevent progression. However, once again, novel imaging techniques have enabled the identification of dementia variants more accurately and the correlation of these with genetics. The burden of vascular disease to cognitive decline can now be more accurately assessed in a longitudinal fashion. Amyotrophic lateral sclerosis (motor neuron disease) genetics have had a prominent advance with the identification of fus gene mutations and these may lead to important insights into pathogenesis and therefore potential targets for intervention. In the interim, the practising neurologist still faces the difficulties of management, particularly of respiratory complications [164–168]. Genetic associations in headache [169–173] and epilepsy [174–183] continue to appear and help define different phenotype correlations. New treatment strategies are becoming available for both, also incorporating lifestyle changes for headache management and new drugs for epilepsy.

The neuromuscular field [184–203] was perhaps the first area of neurology to be transformed by genetics when Duchenne gene mutations were identified. Mutations of primary myopathies including the limb girdle dystrophies and congenital and metabolic myopathies have been identified and have transformed the diagnostic approach to muscle disease. The role of muscle biopsy has changed with this and the European Federation of Neurological Societies guidelines on the use of this investigation in myalgia are welcomed [193]. The genetic discoveries have yet to lead to treatments, but some progress is being made in this field. Neuromuscular disorders and myasthenia gravis are important cases of morbidity and treatment protocols are now refined by autoimmune profiles. Similarly, the diagnosis of immune-based neuropathies and their management has improved outcome in these disorders. Trauma-related neurological dysfunction remains an important cause of long-term disability that encompasses cognitive and physical deficits, epilepsy and spinal cord injury sequelae that are not only of clinical but also of legal relevance [49,56,204–207]. The role of rehabilitation and research into its best delivery and efficacy is an area that deserves greater attention. Inflammatory non-multiple-sclerosis neurological disease [208–216] has traditionally been associated with sarcoid or the vasculopathies, but the discovery of anti-aquaporin antibodies in neuromyelitis optica provided valuable insight into a rather heterogeneous and poorly defined clinical entity. New treatment strategies are now being defined. The same holds for the autoimmune limbic encephalitides. Guidelines [102,105,193,217] remain a vitally important area for education and the development of best medical practice. An enormous amount of work goes into the writing of these and the European Academy of Neurology will be continuing this role through the Scientific Committee. Neurology is a huge area of clinical activity and we have seen publications that cannot easily be incorporated into the major categories above [218–232]. The overlaps with psychiatry, oncology and cardiology in particular are a source of valuable clinical insight. Neurotoxicology is also an important field of development and has the ability to provide valuable insights into potential mechanisms of disease that may in turn have relevance to metabolic pathways involved in genetic neurological disorders.

A. H. V. Schapira Department of Clinical Neurosciences, UCL Institute of Neurology, London, UK

(e-mail: [email protected])

© 2014 EAN


References Stroke pathophysiology 1. Schurks M, Prescott J, Dushkes R, De Vivo I, Rexrode KM. Telomere length and ischaemic stroke in women: a nested case control study. Eur J Neurol 2013; 20: 1068–1074. 2. Sanchez-Porras R, Zheng Z, Santos E, Scholl M, Unterberg AW, Sakowitz OW. The role of spreading depolarization in subarachnoid hemorrhage. Eur J Neurol 2013; 20: 1121–1127. 3. Nasr N, Ssi-Yan-Kai G, Guidolin B, Bonneville F, Larrue V. Transcranial color-coded sonography to predict recurrent transient ischaemic attack/stroke. Eur J Neurol 2013; 20: 1212–1217. 4. Lovkvist H, Sjogren M, Hoglund P, et al. Are 25 SNPs from the CARDIoGRAM study associated with ischaemic stroke? Eur J Neurol 2013; 20: 1284–1291. 5. Kim YJ, Lee DH, Kwon JY, et al. High resolution MRI difference between moyamoya disease and intracranial atherosclerosis. Eur J Neurol 2013; 20: 1311–1318. 6. Prefasi D, Martinez-Sanchez P, Rodriguez-Sanz A, et al. Atrial fibrillation in young stroke patients: do we underestimate its prevalence? Eur J Neurol 2013; 20: 1367–1374. 7. Yesilot BN, Putaala J, Waje-Andreassen U, et al. Etiology of first-ever ischaemic stroke in European young adults: the 15 cities young stroke study. Eur J Neurol 2013; 20: 1431–1439. 8. Zhang S, Zhou Y, Zhang Y, et al. Prevalence and risk factors of asymptomatic intracranial arterial stenosis in a community-based population of Chinese adults. Eur J Neurol 2013; 20: 1479–1485. 9. Mustanoja S, Putaala J, Haapaniemi E, Strbian D, Kaste M, Tatlisumak T. Multiple brain infarcts in young adults: clues for etiologic diagnosis and prognostic impact. Eur J Neurol 2013; 20: 216–222. 10. Michos ED, Gottesman RF. Vitamin D for the prevention of stroke incidence and disability: promising but too early for prime time. Eur J Neurol 2013; 20: 3–4. 11. Heckman MG, Soto-Ortolaza AI, Diehl NN, et al. Genetic variants associated with myocardial infarction in the PSMA6 gene and Chr9p21 are also associated with ischaemic stroke. Eur J Neurol 2013; 20: 300–308. 12. Kim SJ, Shin HY, Ha YS, et al. Paradoxical embolism as a cause of silent brain infarctions in healthy subjects: the ICONS study (Identification of the Cause of Silent Cerebral Infarction in Healthy Subjects). Eur J Neurol 2013; 20: 353–360. 13. Delavaran H, Sjunnesson H, Arvidsson A, et al. Proximity of brain infarcts to regions of endogenous neurogenesis and involvement of striatum in ischaemic stroke. Eur J Neurol 2013; 20: 473–479. 14. Song TJ, Kim J, Lee HS, et al. The frequency of cerebral microbleeds increases with CHADS(2) scores in stroke patients with non-valvular atrial fibrillation. Eur J Neurol 2013; 20: 502–508. 15. Tsai CL, Lee JT, Cheng CA, et al. Reversal of ophthalmic artery flow as a predictor of intracranial hemodynamic compromise: implication for prognosis of severe carotid stenosis. Eur J Neurol 2013; 20: 564–570. 16. Daubail B, Jacquin A, Guilland JC, et al. Serum 25-hydroxyvitamin D predicts severity and prognosis in stroke patients. Eur J Neurol 2013; 20: 57–61.

© 2014 EAN


17. Park JH, Hong KS, Lee J, Kim YJ, Song P. Deep subcortical infarct burden in relation to apolipoprotein B/ AI ratio in patients with intracranial atherosclerotic stenosis. Eur J Neurol 2013; 20: 671–680. 18. Shiue I. Urine phthalate concentrations are higher in people with stroke: United States National Health and Nutrition Examination Surveys (NHANES), 2001 2004. Eur J Neurol 2013; 20: 728–731. 19. Wolf ME, Sauer T, Hennerici MG, Chatzikonstantinou A. Characterization of patients with recurrent ischaemic stroke using the ASCO classification. Eur J Neurol 2013; 20: 812–817. 20. Park JM, Koo JS, Kim BK, et al. Vertebrobasilar dolichoectasia as a risk factor for cerebral microbleeds. Eur J Neurol 2013; 20: 824–830. 21. Shenhar-Tsarfaty S, Waiskopf N, Ofek K, et al. Atherosclerosis and arteriosclerosis parameters in stroke patients associate with paraoxonase polymorphism and esterase activities. Eur J Neurol 2013; 20: 891–898. 22. Olsson S, Jood K. Genetic variation in the receptor for advanced glycation end-products (RAGE) gene and ischaemic stroke. Eur J Neurol 2013; 20: 991–993.

Stroke acute 23. Alons IM, Verheul RJ, Ponjee GA, Jellema K. Optimizing blood pigment analysis in cerebrospinal fluid for the diagnosis of subarachnoid haemorrhage – a practical approach. Eur J Neurol 2013; 20: 193–197. 24. Arauz A, Ruiz A, Pacheco G, et al. Aspirin versus anticoagulation in intra- and extracranial vertebral artery dissection. Eur J Neurol 2013; 20: 167–172. 25. Calleja AI, Cortijo E, Garcia-Bermejo P, et al. Collateral circulation on perfusion-computed tomographysource images predicts the response to stroke intravenous thrombolysis. Eur J Neurol 2013; 20: 795–802. 26. Canhao P, Abreu LF, Ferro JM, et al. Safety of lumbar puncture in patients with cerebral venous thrombosis. Eur J Neurol 2013; 20: 1075–1080. 27. Cho BH, Kim JT, Chang J, Choi KH, Park MS, Cho KH. Prediction of hemorrhagic transformation in acute ischaemic stroke by micro- and macroalbuminuria after intravenous thrombolysis. Eur J Neurol 2013; 20: 1145– 1152. 28. Fischer U, Mono ML, Schroth G, et al. Endovascular therapy in 201 patients with acute symptomatic occlusion of the internal carotid artery. Eur J Neurol 2013; 20: 1017–1024, e87. 29. Grond-Ginsbach C, Giossi A, Aksay SS, et al. Elevated peripheral leukocyte counts in acute cervical artery dissection. Eur J Neurol 2013; 20: 1405–1410. 30. Horstmann S, Rizos T, Guntner J, et al. Does the STAF score help detect paroxysmal atrial fibrillation in acute stroke patients? Eur J Neurol 2013; 20: 147–152. 31. Jung S, Gralla J, Fischer U, et al. Safety of endovascular treatment beyond the 6-h time window in 205 patients. Eur J Neurol 2013; 20: 865–871. 32. Kufner A, Galinovic I, Brunecker P, et al. Early infarct FLAIR hyperintensity is associated with increased hemorrhagic transformation after thrombolysis. Eur J Neurol 2013; 20: 281–285. 33. Marsh EB, Llinas RH, Hillis AE, Gottesman RF. Hemorrhagic transformation in patients with acute ischaemic stroke and an indication for anticoagulation. Eur J Neurol 2013; 20: 962–967.



34. Qureshi AI. Endovascular treatment of acute ischaemic stroke after 6 h of symptom onset: safe but is it efficacious? Eur J Neurol 2013; 20: 863–864. 35. Rodriguez-Luna D, Pineiro S, Rubiera M, et al. Impact of blood pressure changes and course on hematoma growth in acute intracerebral hemorrhage. Eur J Neurol 2013; 20: 1277–1283. 36. Rossi C, Sallustio F, Di Legge S, Stanzione P, Koch G. Transcranial direct current stimulation of the affected hemisphere does not accelerate recovery of acute stroke patients. Eur J Neurol 2013; 20: 202–204. 37. Shimoyama T, Shibazaki K, Kimura K, et al. Admission hyperglycemia causes infarct volume expansion in patients with ICA or MCA occlusion: association of collateral grade on conventional angiography. Eur J Neurol 2013; 20: 109–116. 38. Walter U, Kolbaske S, Patejdl R, et al. Insular stroke is associated with acute sympathetic hyperactivation and immunodepression. Eur J Neurol 2013; 20: 153–159.






Stroke treatment 39. Bugnicourt JM, Flament M, Guillaumont MP, et al. Predictors of newly diagnosed atrial fibrillation in cryptogenic stroke: a cohort study. Eur J Neurol 2013; 20: 1352–1359. 40. Diener HC. More patients with atrial fibrillation need to be anticoagulated. Eur J Neurol 2013; 20: 597–598. 41. Doan QV, Gillard P, Brashear A, et al. Cost-effectiveness of onabotulinumtoxin A for the treatment of wrist and hand disability due to upper-limb post-stroke spasticity in Scotland. Eur J Neurol 2013; 20: 773–780. 42. Giralt-Steinhauer E, Cuadrado-Godia E, Ois A, et al. Comparison between CHADS2 and CHA2DS2-VASc score in a stroke cohort with atrial fibrillation. Eur J Neurol 2013; 20: 623–628. 43. Jungehulsing GJ, Israel H, Safar N, et al. Levetiracetam in patients with central neuropathic post-stroke pain – a randomized, double-blind, placebo-controlled trial. Eur J Neurol 2013; 20: 331–337. 44. Martinez-Martinez MM, Martinez-Sanchez P, Fuentes B, et al. Transient ischaemic attacks clinics provide equivalent and more efficient care than early in-hospital assessment. Eur J Neurol 2013; 20: 338–343. 45. Palm F, Kleemann T, Dos SM, et al. Stroke due to atrial fibrillation in a population-based stroke registry (Ludwigshafen Stroke Study): CHADS(2), CHA(2) DS (2) -VASc score, underuse of oral anticoagulation, and implications for preventive measures. Eur J Neurol 2013; 20: 117–123. 46. Seet RC. Detection of atrial fibrillation in the poststroke setting: challenges and opportunities on the horizon. Eur J Neurol 2013; 20: 1331–1332. 47. Tobin WO, Kinsella JA, Coughlan T, et al. High ontreatment platelet reactivity on commonly prescribed antiplatelet agents following transient ischaemic attack or ischaemic stroke: results from the Trinity Antiplatelet Responsiveness (TRAP) study. Eur J Neurol 2013; 20: 344–352.











Stroke outcomes 48. Al-Khaled M, Awwad H, Matthis C, Eggers J. Stroke recurrence in patients with recently symptomatic carotid stenosis and scheduled for carotid revascularization. Eur J Neurol 2013; 20: 831–835. 49. Aslaksen PM, Orbo M, Elvestad R, Schafer C, Anke A. Prediction of on-road driving ability after traumatic


brain injury and stroke. Eur J Neurol 2013; 20: 1227– 1233. Bejot Y, Aboa-Eboule C, de Maistre E, et al. Prestroke antiplatelet therapy and early prognosis in stroke patients: the Dijon Stroke Registry. Eur J Neurol 2013; 20: 879–890. Bejot Y, Aboa-Eboule C, Jacquin A, et al. Stroke care organization overcomes the deleterious ‘weekend effect’ on 1-month stroke mortality: a population-based study. Eur J Neurol 2013; 20: 1177–1183. Cha MJ, Lee HS, Kim YD, Nam HS, Heo JH. The association between asymptomatic coronary artery disease and CHADS2 and CHA2DS2-VASc scores in patients with stroke. Eur J Neurol 2013; 20: 1256– 1263. Chen YW, Tang SC, Tsai LK, et al. Pre-ICH warfarin use, not antiplatelets, increased case fatality in spontaneous ICH patients. Eur J Neurol 2013; 20: 1128–1134. Chevreul K, Durand-Zaleski I, Gouepo A, Fery-Lemonnier E, Hommel M, Woimant F. Cost of stroke in France. Eur J Neurol 2013; 20: 1094–1100. Choi-Kwon S, Han K, Cho KH, et al. Factors associated with post-stroke anger proneness in ischaemic stroke patients. Eur J Neurol 2013; 20: 1305–1310. Devos H, Hawley CA. Screening tools for fitness to drive after traumatic brain injury and stroke. Eur J Neurol 2013; 20: 1225–1226. Hillbom M. Could the poor outcome of cerebral hemorrhage be improved by more aggressive first-line treatment? Eur J Neurol 2013; 20: 1111–1112. Kuwashiro T, Sugimori H, Ago T, Kuroda J, Kamouchi M, Kitazono T. The impact of predisposing factors on long-term outcome after stroke in diabetic patients: the Fukuoka Stroke Registry. Eur J Neurol 2013; 20: 921–927. Lee SH, Park HK, Ryu WS, et al. Effects of celecoxib on hematoma and edema volumes in primary intracerebral hemorrhage: a multicenter randomized controlled trial. Eur J Neurol 2013; 20: 1161–1169. Maier IL, Bauerle M, Kermer P, Helms HJ, Buettner T. Risk prediction of very early recurrence, death and progression after acute ischaemic stroke. Eur J Neurol 2013; 20: 599–604. Milionis H, Vemmou A, Ntaios G, et al. Ankle-brachial index long-term outcome after first-ever ischaemic stroke. Eur J Neurol 2013; 20: 1471–1478. Narasimhalu K, Wiryasaputra L, Sitoh YY, Kandiah N. Post-stroke subjective cognitive impairment is associated with acute lacunar infarcts in the basal ganglia. Eur J Neurol 2013; 20: 547–551. Purroy F, Jimenez-Caballero PE, Mauri-Capdevila G, et al. Predictive value of brain and vascular imaging including intracranial vessels in transient ischaemic attack patients: external validation of the ABCD3-I score. Eur J Neurol 2013; 20: 1088–1093. Rist PM, Buring JE, Kase CS, Ridker PM, Kurth T. Biomarkers and functional outcomes from ischaemic cerebral events in women: a prospective cohort study. Eur J Neurol 2013; 20: 375–381. Ritter MA, Theismann K, Schmiedel M, Ringelstein EB, Dittrich R. Vascularization of carotid plaque in recently symptomatic patients is associated with the occurrence of transcranial microembolic signals. Eur J Neurol 2013; 20: 1218–1221.

© 2014 EAN


66. Roivainen R, Haapaniemi E, Putaala J, Kaste M, Tatlisumak T. Young adult ischaemic stroke related acute symptomatic and late seizures: risk factors. Eur J Neurol 2013; 20: 1247–1255. 67. Shibazaki K, Kimura K, Uemura J, et al. Atrial fibrillation is associated with severe sleep-disordered breathing in patients with ischaemic stroke and transient ischaemic attack. Eur J Neurol 2013; 20: 266–270. 68. Su SH, Hai J, Zhang L, Yu F, Wu YF. Assessment of cognitive function in adult patients with hemorrhagic moyamoya disease who received no surgical revascularization. Eur J Neurol 2013; 20: 1081–1087. 69. Teuschl Y, Matz K, Brainin M. Prevention of poststroke cognitive decline: a review focusing on lifestyle interventions. Eur J Neurol 2013; 20: 35–49. 70. Turunen KE, Kauranen TV, Laari SP, Mustanoja SM, Tatlisumak T, Poutiainen ET. Cognitive deficits after subcortical infarction are comparable with deficits after cortical infarction. Eur J Neurol 2013; 20: 286–292. 71. Waje-Andreassen U, Thomassen L, Jusufovic M, et al. Ischaemic stroke at a young age is a serious event – final results of a population-based long-term follow-up in Western Norway. Eur J Neurol 2013; 20: 818–823. 72. Yoon Y, Lee DH, Kang DW, et al. Stroke recurrence patterns are predicted by the subtypes and mechanisms of the past, non-cardiogenic stroke. Eur J Neurol 2013; 20: 928–934.

83. 84.







Multiple sclerosis – General 73. Ajdacic-Gross V, Tschopp A, Schmid M, Bopp M, Gutzwiller F. Missed epidemics and missing links: international birth cohort trends in multiple sclerosis. Eur J Neurol 2013; 20: 440–447. 74. Baumstarck K, Pelletier J, Butzkueven H, et al. Healthrelated quality of life as an independent predictor of long-term disability for patients with relapsing remitting multiple sclerosis. Eur J Neurol 2013; 20: 907–909. 75. Benito-Leon J, Mitchell AJ, Rivera-Navarro J, Morales-Gonzalez JM. Impaired health-related quality of life predicts progression of disability in multiple sclerosis. Eur J Neurol 2013; 20: 79–86. 76. Berg-Hansen P, Smestad C, Sandvik L, Harbo HF, Celius EG. Increased disease severity in non-western immigrants with multiple sclerosis in Oslo, Norway. Eur J Neurol 2013; 20: 1546–1552. 77. Bergamaschi R. Can we predict the evolution of an unpredictable disease like multiple sclerosis? Eur J Neurol 2013; 20: 995–996. 78. Devy R, Lehert P, Varlan E, Genty M, Edan G. A short and validated multiple-sclerosis-specific healthrelated quality of life measurement for routine medical practice. Eur J Neurol 2013; 20: 935–941. 79. Gajofatto A, Stefani A, Turatti M, et al. Prevalence of multiple sclerosis in Verona, Italy: an epidemiological and genetic study. Eur J Neurol 2013; 20: 697–703. 80. Galea I, Lederer C, Neuhaus A, et al. A web-based tool for personalized prediction of long-term disease course in patients with multiple sclerosis. Eur J Neurol 2013; 20: 1107–1109. 81. Giordano A, Ferrari G, Radice D, Randi G, Bisanti L, Solari A. Self-assessed health status changes in a community cohort of people with multiple sclerosis: 11 years of follow-up. Eur J Neurol 2013; 20: 681–688. 82. Heussinger N, Kontopantelis E, Rompel O, Paulides M, Trollmann R. Predicting multiple sclerosis following

© 2014 EAN



isolated optic neuritis in children. Eur J Neurol 2013; 20: 1292–1296. Krone B, Ramagopalan SV. Evidence for a multiple sclerosis epidemic? Eur J Neurol 2013; 20: 407. Maghzi AH, Minagar A. Urinary tract infection in multiple sclerosis: a practical algorithm for a common problem. Eur J Neurol 2013; 20: 408–409. Margaritella N, Mendozzi L, Tronci F, et al. The evoked potentials score improves the identification of benign MS without cognitive impairment. Eur J Neurol 2013; 20: 1423–1425. Montgomery S, Hillert J, Bahmanyar S. Hospital admission due to infections in multiple sclerosis patients. Eur J Neurol 2013; 20: 1153–1160. Rakusa M, Murphy O, McIntyre L, et al. Testing for urinary tract colonization before high-dose corticosteroid treatment in acute multiple sclerosis relapses: prospective algorithm validation. Eur J Neurol 2013; 20: 448–452. Runia TF, Jafari N, Hintzen RQ. Application of the 2010 revised criteria for the diagnosis of multiple sclerosis to patients with clinically isolated syndromes. Eur J Neurol 2013; 20: 1510–1516. Schurks M, Bussfeld P. Multiple sclerosis and restless legs syndrome: a systematic review and meta-analysis. Eur J Neurol 2013; 20: 605–615. Weier K, Naegelin Y, Amann M, et al. Six-year followup of a case series with non-communicating syringomyelia in multiple sclerosis. Eur J Neurol 2013; 20: 578– 583. Yamout B, Issa Z, Herlopian A, et al. Predictors of quality of life among multiple sclerosis patients: a comprehensive analysis. Eur J Neurol 2013; 20: 756–764.

Multiple sclerosis pathogenesis 92. Hedstrom AK, Hillert J, Olsson T, Alfredsson L. Exposure to anaesthetic agents does not affect multiple sclerosis risk. Eur J Neurol 2013; 20: 735–739. 93. Kardys A, Weinstock-Guttman B, Dillon M, et al. Cholesterol affects retinal nerve fiber layer thickness in patients with multiple sclerosis with optic neuritis. Eur J Neurol 2013; 20: 1264–1271. 94. Malhotra S, Morcillo-Suarez C, Nurtdinov R, et al. Roles of the ubiquitin peptidase USP18 in multiple sclerosis and the response to interferon-beta treatment. Eur J Neurol 2013; 20: 1390–1397. 95. Sheu JJ, Lin HC. Association between multiple sclerosis and chronic periodontitis: a population-based pilot study. Eur J Neurol 2013; 20: 1053–1059. 96. Van den Berg PJ, Van den Berg GB, Westerhuis LW, Visser LH. Occurrence of CCSVI in patients with MS and its relationship with iron metabolism and varicose veins. Eur J Neurol 2013; 20: 519–526. 97. Young KL, Brandt AU, Petzold A, et al. Loss of retinal nerve fibre layer axons indicates white but not grey matter damage in early multiple sclerosis. Eur J Neurol 2013; 20: 803–811.

Multiple sclerosis treatment 98. Grove RA, Shackelford S, Sopper S, et al. Leukocyte counts in cerebrospinal fluid and blood following firategrast treatment in subjects with relapsing forms of multiple sclerosis. Eur J Neurol 2013; 20: 1032–1042. 99. Portaccio E, Stromillo ML, Goretti B, et al. Natalizumab may reduce cognitive changes and brain atrophy rate in relapsing remitting multiple sclerosis – a



prospective, non-randomized pilot study. Eur J Neurol 2013; 20: 986–990. 100. Romeo M, Martinelli-Boneschi F, Rodegher M, Esposito F, Martinelli V, Comi G. Clinical and MRI predictors of response to interferon-beta and glatiramer acetate in relapsing remitting multiple sclerosis patients. Eur J Neurol 2013; 20: 1060–1067. 101. Rossi S, Motta C, Studer V, et al. Effect of glatiramer acetate on disease reactivation in MS patients discontinuing natalizumab. Eur J Neurol 2013; 20: 87–94.

Parkinson’s disease – General 102. Berardelli A, Wenning GK, Antonini A, et al. EFNS/ MDS-ES/ENS [corrected] recommendations for the diagnosis of Parkinson’s disease. Eur J Neurol 2013; 20: 16–34. 103. Berg D, Godau J, Seppi K, et al. The PRIPS study: screening battery for subjects at risk for Parkinson’s disease. Eur J Neurol 2013; 20: 102–108. 104. Fanciulli A, Strano S, Colosimo C, Caltagirone C, Spalletta G, Pontieri FE. The potential prognostic role of cardiovascular autonomic failure in alpha-synucleinopathies. Eur J Neurol 2013; 20: 231–235. 105. Ferreira JJ, Katzenschlager R, Bloem BR, et al. Summary of the recommendations of the EFNS/MDS-ES review on therapeutic management of Parkinson’s disease. Eur J Neurol 2013; 20: 5–15. 106. Grosset KA, Malek N, Morgan F, Grosset DG. Phase IIa randomized double-blind, placebo-controlled study of inhaled apomorphine as acute challenge for rescuing ‘off’ periods in patients with established Parkinson’s disease. Eur J Neurol 2013; 20: 1445–1450. 107. Hiorth YH, Lode K, Larsen JP. Frequencies of falls and associated features at different stages of Parkinson’s disease. Eur J Neurol 2013; 20: 160–166. 108. La Morgia C, Barboni P, Rizzo G, et al. Loss of temporal retinal nerve fibers in Parkinson disease: a mitochondrial pattern? Eur J Neurol 2013; 20: 198–201. 109. Lim EC. Dosing issues in Parkinson’s disease – patient preferences and their influence on compliance. Eur J Neurol 2013; 20: 1–2. 110. Liu H, Tao Q, Deng H, et al. Genetic analysis of NR4A2 gene in a large population of Han Chinese patients with Parkinson’s disease. Eur J Neurol 2013; 20: 584–587. 111. Olivares RJ, Arjona PA, Barrero Hernandez FJ, Martin GM, Gil EB. Utility of transcranial sonography in the diagnosis of drug-induced parkinsonism: a prospective study. Eur J Neurol 2013; 20: 1451–1458. 112. Perez-Lloret S. Apomorphine for the treatment of refractory motor fluctuations in late stage Parkinson’s disease: an old drug revisited. Eur J Neurol 2013; 20: 1427–1428. 113. Poewe W, Seppi K. Diagnosis of drug-induced parkinsonism: can transcranial sonography make the difference? Eur J Neurol 2013; 20: 1429–1430. 114. Rocchi L, Conte A, Nardella A, et al. Somatosensory temporal discrimination threshold may help to differentiate patients with multiple system atrophy from patients with Parkinson’s disease. Eur J Neurol 2013; 20: 714–719. 115. Schapira AH, Stocchi F, Borgohain R, et al. Longterm efficacy and safety of safinamide as add-on therapy in early Parkinson’s disease. Eur J Neurol 2013; 20: 271–280.

116. Schapira AH, Barone P, Hauser RA, et al. Patientreported convenience of once-daily versus three-timesdaily dosing during long-term studies of pramipexole in early and advanced Parkinson’s disease. Eur J Neurol 2013; 20: 50–56. 117. Schapira AH, Barone P, Hauser RA, et al. Success rate, efficacy, and safety/tolerability of overnight switching from immediate- to extended-release pramipexole in advanced Parkinson’s disease. Eur J Neurol 2013; 20: 180–187. 118. Stathis P, Smpiliris M, Konitsiotis S, Mitsikostas DD. Nocebo as a potential confounding factor in clinical trials for Parkinson’s disease treatment: a meta-analysis. Eur J Neurol 2013; 20: 527–533. 119. Stocchi F, Bloem BR. Move for Change Part II: a European survey evaluating the impact of the EPDA Charter for people with Parkinson’s disease. Eur J Neurol 2013; 20: 461–472. 120. Zhao YJ, Tan LC, Au WL, et al. Estimating the lifetime economic burden of Parkinson’s disease in Singapore. Eur J Neurol 2013; 20: 368–374.

Parkinson’s disease pathogenesis 121. Jesus S, Perez I, Caceres-Redondo MT, et al. Low serum uric acid concentration in Parkinson’s disease in southern Spain. Eur J Neurol 2013; 20: 208–210. 122. Kumar KR, Ramirez A, Gobel A, et al. Glucocerebrosidase mutations in a Serbian Parkinson’s disease population. Eur J Neurol 2013; 20: 402–405. 123. Mateo I, Gonzalez-Aramburu I, Pozueta A, et al. Reduced serum progranulin level might be associated with Parkinson’s disease risk. Eur J Neurol 2013; 20: 1571–1573.

Parkinson’s disease – non-motor 124. Ceravolo R, Frosini D, Poletti M, et al. Mild affective symptoms in de novo Parkinson’s disease patients: relationship with dopaminergic dysfunction. Eur J Neurol 2013; 20: 480–485. 125. Louter M, van der Marck MA, Pevernagie DA, Munneke M, Bloem BR, Overeem S. Sleep matters in Parkinson’s disease: use of a priority list to assess the presence of sleep disturbances. Eur J Neurol 2013; 20: 259–265. 126. Defazio G, Tinazzi M, Berardelli A. How pain arises in Parkinson’s disease? Eur J Neurol 2013; 20: 1517– 1523. 127. Clark AJ, Ritz B, Prescott E, Rod NH. Psychosocial risk factors, pre-motor symptoms and first-time hospitalization with Parkinson’s disease: a prospective cohort study. Eur J Neurol 2013; 20: 1113–1120. 128. Granovsky Y, Schlesinger I, Fadel S, Erikh I, Sprecher E, Yarnitsky D. Asymmetric pain processing in Parkinson’s disease. Eur J Neurol 2013; 20: 1375–1382. 129. Lin CH, Wu RM, Chang HY, Chiang YT, Lin HH. Preceding pain symptoms and Parkinson’s disease: a nationwide population-based cohort study. Eur J Neurol 2013; 20: 1398–1404. 130. Martinez-Martin P, Rojo-Abuin JM, Dujardin K, et al. Designing a new scale to measure anxiety symptoms in Parkinson’s disease: item selection based on canonical correlation analysis. Eur J Neurol 2013; 20: 1198–1203. 131. Rod NH, Bordelon Y, Thompson A, Marcotte E, Ritz B. Major life events and development of major depression in Parkinson’s disease patients. Eur J Neurol 2013; 20: 663–670.

© 2014 EAN


132. Saenz A, Doe de Maindreville A, Henry A, de Labbey S, Bakchine S, Ehrle N. Recognition of facial and musical emotions in Parkinson’s disease. Eur J Neurol 2013; 20: 571–577.

Other movement disorders 133. Bohlen S, Ekwall C, Hellstrom K, et al. Physical therapy in Huntington’s disease – toward objective assessments? Eur J Neurol 2013; 20: 389–393. 134. Dostal M, Weber-Schoendorfer C, Sobesky J, Schaefer C. Pregnancy outcome following use of levodopa, pramipexole, ropinirole, and rotigotine for restless legs syndrome during pregnancy: a case series. Eur J Neurol 2013; 20: 1241–1246. 135. Giardino G, Fusco A, Romano R, et al. Betamethasone therapy in ataxia telangiectasia: unraveling the rationale of this serendipitous observation on the basis of the pathogenesis. Eur J Neurol 2013; 20: 740–747. 136. Kostic VS, Mijajlovic M, Smajlovic D, Lukic MJ, Tomic A, Svetel M. Transcranial brain sonography findings in two main variants of progressive supranuclear palsy. Eur J Neurol 2013; 20: 552–557. 137. Lambrecq V, Langbour N, Guehl D, Bioulac B, Burbaud P, Rotge JY. Evolution of brain gray matter loss in Huntington’s disease: a meta-analysis. Eur J Neurol 2013; 20: 315–321. 138. Lin CH, Wu VC, Li WY, et al. Restless legs syndrome in end-stage renal disease: a multicenter study in Taiwan. Eur J Neurol 2013; 20: 1025–1031. 139. Meneret A, Gaudebout C, Riant F, Vidailhet M, Depienne C, Roze E. PRRT2 mutations and paroxysmal disorders. Eur J Neurol 2013; 20: 872–878. 140. Prodi E, Grisoli M, Panzeri M, et al. Supratentorial and pontine MRI abnormalities characterize recessive spastic ataxia of Charlevoix Saguenay. A comprehensive study of an Italian series. Eur J Neurol 2013; 20: 138–146. 141. Saini J, Bagepally BS, Sandhya M, et al. Subcortical structures in progressive supranuclear palsy: vertexbased analysis. Eur J Neurol 2013; 20: 493–501. 142. Sikk K, Haldre S, Aquilonius SM, et al. Manganeseinduced parkinsonism in methcathinone abusers: biomarkers of exposure and follow-up. Eur J Neurol 2013; 20: 915–920. 143. Thompson JA, Cruickshank TM, Penailillo LE, et al. The effects of multidisciplinary rehabilitation in patients with early-to-middle-stage Huntington’s disease: a pilot study. Eur J Neurol 2013; 20: 1325–1329. 144. Trenkwalder C. Emergency call from gynecologists: how to treat restless legs syndrome during pregnancy? Eur J Neurol 2013; 20: 1223–1224. 145. Whitwell JL, Jack CR Jr, Parisi JE, et al. Midbrain atrophy is not a biomarker of progressive supranuclear palsy pathology. Eur J Neurol 2013; 20: 1417–1422. 146. Whitwell JL, Duffy JR, Strand EA, et al. Neuroimaging comparison of primary progressive apraxia of speech and progressive supranuclear palsy. Eur J Neurol 2013; 20: 629–637. 147. Zhang P, Gao Z, Jiang Y, et al. Follow-up study of 25 Chinese children with PLA2G6-associated neurodegeneration. Eur J Neurol 2013; 20: 322–330.

Other movement disorders – essential tremor 148. de Verdal M, Renard D, Collombier L, et al. I123-FPCIT single-photon emission tomography in patients with long-standing mixed tremor. Eur J Neurol 2013; 20: 382–388.

© 2014 EAN


149. Louis ED, Ottman R. Is there a one-way street from essential tremor to Parkinson’s disease? Possible biological ramifications. Eur J Neurol 2013; 20: 1440–1444. 150. Louis ED. The primary type of tremor in essential tremor is kinetic rather than postural: cross-sectional observation of tremor phenomenology in 369 cases. Eur J Neurol 2013; 20: 725–727. 151. Louis ED, Gerbin M, Galecki M. Essential tremor 10, 20, 30, 40: clinical snapshots of the disease by decade of duration. Eur J Neurol 2013; 20: 949–954.

Other movement disorders – dystonia 152. Loyola DP, Camargos S, Maia D, Cardoso F. Sensory tricks in focal dystonia and hemifacial spasm. Eur J Neurol 2013; 20: 704–707. 153. Lungu C, Considine E, Zahir S, Ponsati B, Arrastia S, Hallett M. Pilot study of topical acetyl hexapeptide-8 in the treatment for blepharospasm in patients receiving botulinum toxin therapy. Eur J Neurol 2013; 20: 515–518.

Alzheimer’s disease and other dementias 154. Andro M, Le Squere P, Estivin S, Gentric A. Anaemia and cognitive performances in the elderly: a systematic review. Eur J Neurol 2013; 20: 1234–1240. 155. Gil-Navarro S, Lomena F, Cot A, et al. Decreased striatal dopamine transporter uptake in the non-fluent/ agrammatic variant of primary progressive aphasia. Eur J Neurol 2013; 20: 1459-e126. 156. Gomez-Tortosa E, Guerrero-Lopez R, Gil-Neciga E, et al. Plasma progranulin levels in cortical dementia phenotypes with asymmetric perisylvian atrophy. Eur J Neurol 2013; 20: 1319–1324. 157. Gurol ME. Cerebral hypoperfusion and white matter disease in healthy elderly and patients with Alzheimer’s disease. Eur J Neurol 2013; 20: 214–215. 158. Haubois G, de Decker L, Annweiler C, et al. Derivation and validation of a Short Form of the Mini-Mental State Examination for the screening of dementia in older adults with a memory complaint. Eur J Neurol 2013; 20: 588–590. 159. Huang CW, Chang WN, Huang SH, et al. Impact of homocysteine on cortical perfusion and cognitive decline in mild Alzheimer’s dementia. Eur J Neurol 2013; 20: 1191–1197. 160. Lahiri DK, Ray B. Abnormal cerebrospinal fluid (CSF) dynamics in Alzheimer’s disease and normal pressure hydrocephalus: CSF-amyloid beta precursor protein metabolites as possible biomarkers. Eur J Neurol 2013; 20: 211–213. 161. Leinonen V, Rinne JO, Virtanen KA, et al. Positron emission tomography with [18F]flutemetamol and [11C] PiB for in vivo detection of cerebral cortical amyloid in normal pressure hydrocephalus patients. Eur J Neurol 2013; 20: 1043–1052. 162. Makedonov I, Black SE, MacIntosh BJ. Cerebral small vessel disease in aging and Alzheimer’s disease: a comparative study using MRI and SPECT. Eur J Neurol 2013; 20: 243–250. 163. Tabara Y, Igase M, Okada Y, et al. Association of Chr17q25 with cerebral white matter hyperintensities and cognitive impairment: the J-SHIPP study. Eur J Neurol 2013; 20: 860–862.

Motor neuron disease, amyotrophic lateral sclerosis 164. Korner S, Kollewe K, Ilsemann J, et al. Prevalence and prognostic impact of comorbidities in amyotrophic lateral sclerosis. Eur J Neurol 2013; 20: 647–654.



165. Raaphorst J, Tuijp J, Verweij L, et al. Treatment of respiratory impairment in patients with motor neuron disease in the Netherlands: patient preference and timing of referral. Eur J Neurol 2013; 20: 1524– 1530. 166. Roth NM, Saidha S, Zimmermann H, et al. Optical coherence tomography does not support optic nerve involvement in amyotrophic lateral sclerosis. Eur J Neurol 2013; 20: 1170–1176. 167. Swash M. Ventilation in ALS. Eur J Neurol 2013; 20: 1508–1509. 168. Waibel S, Neumann M, Rosenbohm A, et al. Truncating mutations in FUS/TLS give rise to a more aggressive ALS-phenotype than missense mutations: a clinicogenetic study in Germany. Eur J Neurol 2013; 20: 540– 546.

Headache 169. Esserlind AL, Christensen AF, Le H, et al. Replication and meta-analysis of common variants identifies a genome-wide significant locus in migraine. Eur J Neurol 2013; 20: 765–772. 170. Huang Y, Cai X, Song X, et al. Steroids for preventing recurrence of acute severe migraine headaches: a metaanalysis. Eur J Neurol 2013; 20: 1184–1190. 171. Ozge A, Sasmaz T, Bugdayci R, et al. The prevalence of chronic and episodic migraine in children and adolescents. Eur J Neurol 2013; 20: 95–101. 172. Verrotti A, Agostinelli S, D’Egidio C, et al. Impact of a weight loss program on migraine in obese adolescents. Eur J Neurol 2013; 20: 394–397. 173. Wang J, Huang Q, Li N, Tan G, Chen L, Zhou J. Triggers of migraine and tension-type headache in China: a clinic-based survey. Eur J Neurol 2013; 20: 689–696.

Epilepsy 174. Agostinelli S, Traverso M, Accorsi P, et al. Early-onset absence epilepsy: SLC2A1 gene analysis and treatment evolution. Eur J Neurol 2013; 20: 856–859. 175. Balestrini S, Cagnetti C, Foschi N, et al. Emergency room access for recurring seizures: when and why. Eur J Neurol 2013; 20: 1411–1416. 176. Belcastro V, Striano P, Parisi P. Interictal and periictal headache in patients with epilepsy: migraine-triggered seizures or epilepsy-triggered headache? Eur J Neurol 2013; 20: 1333–1334. 177. Duchaczek B, Ghaeni L, Matzen J, Holtkamp M. Interictal and periictal headache in patients with epilepsy. Eur J Neurol 2013; 20: 1360–1366. 178. Hilger E, Zimprich F, Jung R, Pataraia E, Baumgartner C, Bonelli S. Postictal psychosis in temporal lobe epilepsy: a case control study. Eur J Neurol 2013; 20: 955–961. 179. Labate A, Mumoli L, Fratto A, Quattrone A, Gambardella A. Hippocampal sclerosis worsens autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) phenotype related to CHRNB2 mutation. Eur J Neurol 2013; 20: 591–593. 180. Sellner J, Trinka E. Clinical characteristics, risk factors and pre-surgical evaluation of post-infectious epilepsy. Eur J Neurol 2013; 20: 429–439. 181. Sturiale CL, Rigante L, Puca A, et al. Angioarchitectural features of brain arteriovenous malformations associated with seizures: a single center retrospective series. Eur J Neurol 2013; 20: 849–855.

182. Witt JA, Elger CE, Helmstaedter C. Impaired verbal fluency under topiramate – evidence for synergistic negative effects of epilepsy, topiramate, and polytherapy. Eur J Neurol 2013; 20: 130–137. 183. Zaccara G, Giovannelli F, Cincotta M, Verrotti A, Grillo E. The adverse event profile of perampanel: meta-analysis of randomized controlled trials. Eur J Neurol 2013; 20: 1204–1211.

Neuromuscular 184. Argyriou AA, Briani C, Cavaletti G, et al. Advanced age and liability to oxaliplatin-induced peripheral neuropathy: post hoc analysis of a prospective study. Eur J Neurol 2013; 20: 788–794. 185. Briani C, Campagnolo M, Lucchetta M, et al. Ultrasound assessment of oxaliplatin-induced neuropathy and correlations with neurophysiologic findings. Eur J Neurol 2013; 20: 188–192. 186. Bsteh G, Wanschitz JV, Gruber H, Seppi K, Loscher WN. Prognosis and prognostic factors in non-traumatic acute-onset compressive mononeuropathies – radial and peroneal mononeuropathies. Eur J Neurol 2013; 20: 981–985. 187. Collongues N, Depienne C, Boehm N, et al. Novel SPG10 mutation associated with dysautonomia, spinal cord atrophy, and skin biopsy abnormality. Eur J Neurol 2013; 20: 398–401. 188. Dimberg EL. Grip strength in CIDP: does one function fit all? Eur J Neurol 2013; 20: 733–734. 189. Galban-Horcajo F, Fitzpatrick AM, Hutton AJ, et al. Antibodies to heteromeric glycolipid complexes in multifocal motor neuropathy. Eur J Neurol 2013; 20: 62– 70. 190. Goedee HS, Brekelmans GJ, van Asseldonk JT, Beekman R, Mess WH, Visser LH. High resolution sonography in the evaluation of the peripheral nervous system in polyneuropathy – a review of the literature. Eur J Neurol 2013; 20: 1342–1351. 191. Gregianin E, Vazza G, Scaramel E, et al. A novel SACS mutation results in non-ataxic spastic paraplegia and peripheral neuropathy. Eur J Neurol 2013; 20: 1486–1491. 192. Kamradt T, Rasch C, Schuld C, et al. Spinal cord injury: association with axonal peripheral neuropathy in severely paralysed limbs. Eur J Neurol 2013; 20: 843–848. 193. Kyriakides T, Angelini C, Schaefer J, et al. EFNS review on the role of muscle biopsy in the investigation of myalgia. Eur J Neurol 2013; 20: 997–1005. 194. Liewluck T, Winder TL, Dimberg EL, et al. ANO5muscular dystrophy: clinical, pathological and molecular findings. Eur J Neurol 2013; 20: 1383–1389. 195. Linssen WH, de Voogt WG, Krahn M, et al. Longterm follow-up study on patients with Miyoshi phenotype of distal muscular dystrophy. Eur J Neurol 2013; 20: 968–974. 196. Lozeron P, Theaudin M, Mincheva Z, Ducot B, Lacroix C, Adams D. Effect on disability and safety of tafamidis in late onset of Met30 transthyretin familial amyloid polyneuropathy. Eur J Neurol 2013; 20: 1539– 1545. 197. Maniaol AH, Boldingh M, Brunborg C, Harbo HF, Tallaksen CM. Smoking and socio-economic status may affect myasthenia gravis. Eur J Neurol 2013; 20: 453–460.

© 2014 EAN


198. Markvardsen LH, Debost JC, Harbo T, et al. Subcutaneous immunoglobulin in responders to intravenous therapy with chronic inflammatory demyelinating polyradiculoneuropathy. Eur J Neurol 2013; 20: 836–842. 199. Nakata R, Motomura M, Masuda T, et al. Thymus histology and concomitant autoimmune diseases in Japanese patients with muscle-specific receptor tyrosine kinase-antibody-positive myasthenia gravis. Eur J Neurol 2013; 20: 1272–1276. 200. Pedersen EG, Pottegard A, Hallas J, et al. Use of azathioprine for non-thymoma myasthenia and risk of cancer: a nationwide case control study in Denmark. Eur J Neurol 2013; 20: 942–948. 201. Sandell SM, Mahjneh I, Palmio J, Tasca G, Ricci E, Udd BA. ‘Pathognomonic’ muscle imaging findings in DNAJB6 mutated LGMD1D. Eur J Neurol 2013; 20: 1553–1559. 202. Vanhoutte EK, Latov N, Deng C, et al. Vigorimeter grip strength in CIDP: a responsive tool that rapidly measures the effect of IVIG – the ICE study. Eur J Neurol 2013; 20: 748–755. 203. Zach H, Cetin H, Hilger E, et al. The effect of early prednisolone treatment on the generalization rate in ocular myasthenia gravis. Eur J Neurol 2013; 20: 708– 713.

Trauma 204. Furlan JC, Fehlings MG. Blood alcohol concentration as a determinant of outcomes after traumatic spinal cord injury. Eur J Neurol 2013; 20: 1101–1106. 205. Lannsjo M, Backheden M, Johansson U, Af Geijerstam JL, Borg J. Does head CT scan pathology predict outcome after mild traumatic brain injury? Eur J Neurol 2013; 20: 124–129. 206. Theadom A, Mahon S, Barker-Collo S, et al. Enzogenol for cognitive functioning in traumatic brain injury: a pilot placebo-controlled RCT. Eur J Neurol 2013; 20: 1135–1144. 207. Sabre L, Hagen EM, Rekand T, Asser T, Korv J. Traumatic spinal cord injury in two European countries: why the differences? Eur J Neurol 2013; 20: 293– 299.

Neuro-inflammatory 208. Banati M, Csecsei P, Koszegi E, et al. Antibody response against gastrointestinal antigens in demyelinating diseases of the central nervous system . Eur J Neurol 2013; 20: 1492–1495. 209. Chanson JB, Lamy J, Rousseau F, et al. White matter volume is decreased in the brain of patients with neuromyelitis optica. Eur J Neurol 2013; 20: 361–367. 210. Frisch C, Malter MP, Elger CE, Helmstaedter C. Neuropsychological course of voltage-gated potassium channel and glutamic acid decarboxylase antibody related limbic encephalitis. Eur J Neurol 2013; 20: 1297–1304. 211. Kim W, Kim SH, Huh SY, et al. Reduced antibody formation after influenza vaccination in patients with neuromyelitis optica spectrum disorder treated with rituximab. Eur J Neurol 2013; 20: 975–980. 212. Kiyat-Atamer A, Ekizoglu E, Tuzun E, et al. Longterm MRI findings in neuromyelitis optica: seropositive versus seronegative patients. Eur J Neurol 2013; 20: 781–787. 213. O’Dwyer JP, Al-Moyeed BA, Farrell MA, et al. Neurosarcoidosis-related intracranial haemorrhage: three

© 2014 EAN


new cases and a systematic review of the literature. Eur J Neurol 2013; 20: 71–78. 214. Oyanguren B, Sanchez V, Gonzalez FJ, et al. Limbic encephalitis: a clinical-radiological comparison between herpetic and autoimmune etiologies. Eur J Neurol 2013; 20: 1566–1570. 215. Steinbrink F, Evers S, Buerke B, et al. Cognitive impairment in HIV infection is associated with MRI and CSF pattern of neurodegeneration. Eur J Neurol 2013; 20: 420–428. 216. Tjensvoll AB, Harboe E, Goransson LG, et al. Headache in primary Sjogren’s syndrome: a populationbased retrospective cohort study. Eur J Neurol 2013; 20: 558–563.

Guidelines 217. Leone MA, Brainin M, Boon P, Pugliatti M, Keindl M, Bassetti CL. Guidance for the preparation of neurological management guidelines by EFNS scientific task forces – revised recommendations 2012. Eur J Neurol 2013; 20: 410–419.

General 218. Benito-Leon J, Mitchell AJ, Hernandez-Gallego J, Bermejo-Pareja F. Obesity and impaired cognitive functioning in the elderly: a population-based cross-sectional study (NEDICES). Eur J Neurol 2013; 20: 899– 907. 219. Chen C, Xu T, Lu Y, Chen J, Wu S. The efficacy of temozolomide for recurrent glioblastoma multiforme. Eur J Neurol 2013; 20: 223–230. 220. Eddy CM, Cavanna AE. ‘It’s a curse!’: coprolalia in Tourette syndrome. Eur J Neurol 2013; 20: 1467– 1470. 221. Graff-Radford NR, Knopman DS, Penman AD, Coker LH, Mosley TH. Do systolic BP and pulse pressure relate to ventricular enlargement? Eur J Neurol 2013; 20: 720–724. 222. Hammer MB, Eleuch-Fayache G, Gibbs JR, et al. Exome sequencing: an efficient diagnostic tool for complex neurodegenerative disorders. Eur J Neurol 2013; 20: 486–492. 223. Jankelowitz SK, Spies JM, Burke D. Late-onset neurological symptoms in thalidomide-exposed subjects: a study of an Australasian cohort. Eur J Neurol 2013; 20: 509–514. 224. Lee CC, Su YC, Chien SH, et al. Increased stroke risk in Bell’s palsy patients without steroid treatment. Eur J Neurol 2013; 20: 616–622. 225. McColgan P, McKeown PP, Selai C, Doherty-Allan R, McCarron MO. Educational interventions in neurology: a comprehensive systematic review. Eur J Neurol 2013; 20: 1006–1016. 226. Miyajima M, Nakajima M, Ogino I, Miyata H, Motoi Y, Arai H. Soluble amyloid precursor protein alpha in the cerebrospinal fluid as a diagnostic and prognostic biomarker for idiopathic normal pressure hydrocephalus. Eur J Neurol 2013; 20: 236–242. 227. Olesen J. Ten-year anniversary of the European Brain Council: the major achievements. Eur J Neurol 2013; 20: 595–596. 228. Schapira AH. Progress in European neurology 2012– 2013. Eur J Neurol 2013; 20: 1499–1507. 229. Schestatsky P, Dall-Agnol L, Gheller L, et al. Pain autonomic interaction after work-induced sleep restriction. Eur J Neurol 2013; 20: 638–646.



230. Van ME, Wozniak A, Geussens pseudoprogression in glioblastoma Neurol 2013; 20: 1335–1341. 231. Welschehold S, Kerz T, Boor S, intracranial circulatory arrest in

Y, et al. Defining multiforme. Eur J et al. Detection of brain death using

cranial CT-angiography. Eur J Neurol 2013; 20: 173– 179. 232. Wijnia JW, Oudman E. Biomarkers of delirium as a clue to diagnosis and pathogenesis of Wernicke Korsakoff syndrome. Eur J Neurol 2013; 20: 1531–1538.

© 2014 EAN

Recent advances in neurology 2013-2014.

Recent advances in neurology 2013-2014. - PDF Download Free
132KB Sizes 2 Downloads 7 Views

Recommend Documents

Recent imaging advances in neurology.
Over the recent years, the application of neuroimaging techniques such as magnetic resonance imaging (MRI) and positron emission tomography (PET) has considerably advanced the understanding of complex neurological disorders. PET is a powerful molecul

Recent Advances in Voltammetry.
Recent progress in the theory and practice of voltammetry is surveyed and evaluated. The transformation over the last decade of the level of modelling and simulation of experiments has realised major advances such that electrochemical techniques can

Recent advances in epilepsy.
We have reviewed some of the important studies published within the last 18 months that have advanced our understanding of the epilepsies, their aetiology and treatment. Clinical studies have revealed new insights into old themes including seizure pr

Recent advances in electrochemiluminescence.
The great success of electrochemiluminescence (ECL) for in vitro diagnosis (IVD) and its promising potential in light-emitting devices greatly promote recent ECL studies. More than 45% of ECL articles were published after 2010, and the first internat

Recent advances in epilepsy.
This paper reviews advances in epilepsy in recent years with an emphasis on therapeutics and underlying mechanisms, including status epilepticus, drug and surgical treatments. Lessons from rarer epilepsies regarding the relationship between epilepsy

Recent advances in osteosarcoma.
Although osteosarcoma (OS) is a rare malignancy, it is ranked among the leading causes of cancer-related death in the pediatric age group. The cancer's low prevalence and its large tumor heterogeneity make it difficult to obtain meaningful progress i