Chin J Integr Med 2013 Dec;19(12):927-934

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ORIGINAL ARTICLE Qufeng Tongluo Prescription (祛风通络方) Inhibits Mesangial Cell Proliferation and Promotes Apoptosis through Regulating Cell Cycle Progression WU Xi-li (吴喜利)1, AN Peng (安 鹏)1, YE Bing-yu (叶冰玉)1, SHI Xing-min (石兴民)2, SUN Wan-sen (孙万森)1, FU Rong-guo (付荣国)3, WANG Zhu (王 竹)1, and QIAO Cheng-lin (乔成林)1 ABSTRACT Objective: To study the effects and possible underlying mechanism of Qufeng Tongluo Prescription (祛风通络方, QFTL) on the regulation of mesangial cells (MCs) proliferation and apoptosis. Methods: The MCs used in this experiment have undergone five passages induced by lipopolysaccharide (LPS). Changes in the proliferation, apoptosis, cell cycle regulatory proteins and mRNA expression levels of the MCs after administration of Benazepril or QFTL were measured by methyl thiazolyl tetrazolium (MTT) reduction assay, flow cytometry, Western blot and quantitative real-time polymerase chain reaction (qRT-PCR), respectively. Results: The addition of Benazepril or QFTL serum inhibited LPS-induced MC proliferation after treatment for 24, 48 and 72 h, respectively (P

Qufeng Tongluo Prescription () inhibits mesangial cell proliferation and promotes apoptosis through regulating cell cycle progression.

To study the effects and possible underlying mechanism of Qufeng Tongluo Prescription (, QFTL) on the regulation of mesangial cells (MCs) proliferatio...
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