Author's Accepted Manuscript Quality of life in patients treated for penile cancer Jacobien M. Kieffer, Rosa S. Djajadiningrat, Erik AM. van Muilekom, Niels M. Graafland, Simon Horenblas, Neil K. Aaronson
PII: DOI: Reference:
S0022-5347(14)03342-4 10.1016/j.juro.2014.04.014 JURO 11393
To appear in: The Journal of Urology Accepted Date: 10 April 2014 Please cite this article as: Kieffer JM, Djajadiningrat RS, van Muilekom EA, Graafland NM, Horenblas S, Aaronson NK, Quality of life in patients treated for penile cancer, The Journal of Urology® (2014), doi: 10.1016/j.juro.2014.04.014. DISCLAIMER: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our subscribers we are providing this early version of the article. The paper will be copy edited and typeset, and proof will be reviewed before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to The Journal pertain. All press releases and the articles they feature are under strict embargo until uncorrected proof of the article becomes available online. We will provide journalists and editors with full-text copies of the articles in question prior to the embargo date so that stories can be adequately researched and written. The standard embargo time is 12:01 AM ET on that date.
ACCEPTED MANUSCRIPT
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Quality of life in patients treated for penile cancer
Jacobien M Kieffer*, Rosa S Djajadiningrat*, Erik AM van Muilekom, Niels M Graafland, Simon Horenblas and Neil K Aaronson
(*These authors contributed equally to this work)
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From the Division of Psychosocial Research and Epidemiology (JMK, NKA) and the Department of Urology (RSD, EAMM, NMG, SH), the Netherlands Cancer Institute, Amsterdam, the Netherlands
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SC
12 Address all correspondence to:
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Neil K. Aaronson, Ph.D.
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Division of Psychosocial Research and Epidemiology
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The Netherlands Cancer Institute
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Plesmanlaan 121, NL-1066 CX Amsterdam, the Netherlands
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Phone: +31 20 512 2481; Fax: +31 20 512 2322; e-mail: [email protected]
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M AN U
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Conflict of interest or funding: None
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Keywords: Penile cancer, quality of life, sexual functioning, squamous cell carcinoma, cancer survivorship
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Running head: QoL after penile cancer treatment
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Word count text (excluding abstract): 2402 Word count abstract: 242
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ACCEPTED MANUSCRIPT Abstract Purpose: To assess the impact of primary surgery (penile-sparing surgery versus (partial) penectomy), and lymphadenectomy on sexuality and health-related quality of life (HRQOL).
Materials and Methods: We invited patients surgically treated for penile cancer in the Netherlands Cancer Institute between 2003 and 2008 (N=147) to complete the International Index of Erectile
RI PT
Function (IIEF-15), the Short Form-36 Health Survey (SF-36), the Impact of Cancer questionnaire (IOCv2), and questions about urinary function. We evaluated the impact of primary surgery type and lymphadenectomy on these outcomes. We also compared the patients’ SF-36 scores with those of an age- and sex-matched normative sample from the general Dutch population.
SC
Results: Ninety patients (62%) returned a completed questionnaire. Type and extent of surgery was not associated significantly with most of the study outcomes assessed. However, men who underwent (partial) penectomy reported significantly more problems than those who had had penile-sparing
M AN U
surgery with orgasm (p=0.031;ES=0.54), appearance concerns (p=0.008;(ES)=0.61), life interference (p=0.032;ES=0.49), and urinary function (83% versus 43%, p
PII: DOI: Reference:
S0022-5347(14)03342-4 10.1016/j.juro.2014.04.014 JURO 11393
To appear in: The Journal of Urology Accepted Date: 10 April 2014 Please cite this article as: Kieffer JM, Djajadiningrat RS, van Muilekom EA, Graafland NM, Horenblas S, Aaronson NK, Quality of life in patients treated for penile cancer, The Journal of Urology® (2014), doi: 10.1016/j.juro.2014.04.014. DISCLAIMER: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our subscribers we are providing this early version of the article. The paper will be copy edited and typeset, and proof will be reviewed before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to The Journal pertain. All press releases and the articles they feature are under strict embargo until uncorrected proof of the article becomes available online. We will provide journalists and editors with full-text copies of the articles in question prior to the embargo date so that stories can be adequately researched and written. The standard embargo time is 12:01 AM ET on that date.
ACCEPTED MANUSCRIPT
10
Quality of life in patients treated for penile cancer
Jacobien M Kieffer*, Rosa S Djajadiningrat*, Erik AM van Muilekom, Niels M Graafland, Simon Horenblas and Neil K Aaronson
(*These authors contributed equally to this work)
RI PT
1 2 3 4 5 6 7 8 9
From the Division of Psychosocial Research and Epidemiology (JMK, NKA) and the Department of Urology (RSD, EAMM, NMG, SH), the Netherlands Cancer Institute, Amsterdam, the Netherlands
11
SC
12 Address all correspondence to:
14
Neil K. Aaronson, Ph.D.
15
Division of Psychosocial Research and Epidemiology
16
The Netherlands Cancer Institute
17
Plesmanlaan 121, NL-1066 CX Amsterdam, the Netherlands
18
Phone: +31 20 512 2481; Fax: +31 20 512 2322; e-mail: [email protected]
TE D
19
M AN U
13
20
Conflict of interest or funding: None
21 22 23 24 25 26 27 28 29 30 31
Keywords: Penile cancer, quality of life, sexual functioning, squamous cell carcinoma, cancer survivorship
EP
Running head: QoL after penile cancer treatment
AC C
Word count text (excluding abstract): 2402 Word count abstract: 242
1
ACCEPTED MANUSCRIPT Abstract Purpose: To assess the impact of primary surgery (penile-sparing surgery versus (partial) penectomy), and lymphadenectomy on sexuality and health-related quality of life (HRQOL).
Materials and Methods: We invited patients surgically treated for penile cancer in the Netherlands Cancer Institute between 2003 and 2008 (N=147) to complete the International Index of Erectile
RI PT
Function (IIEF-15), the Short Form-36 Health Survey (SF-36), the Impact of Cancer questionnaire (IOCv2), and questions about urinary function. We evaluated the impact of primary surgery type and lymphadenectomy on these outcomes. We also compared the patients’ SF-36 scores with those of an age- and sex-matched normative sample from the general Dutch population.
SC
Results: Ninety patients (62%) returned a completed questionnaire. Type and extent of surgery was not associated significantly with most of the study outcomes assessed. However, men who underwent (partial) penectomy reported significantly more problems than those who had had penile-sparing
M AN U
surgery with orgasm (p=0.031;ES=0.54), appearance concerns (p=0.008;(ES)=0.61), life interference (p=0.032;ES=0.49), and urinary function (83% versus 43%, p
