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doi:10.1111/jpc.12755
VIEWPOINT
Pulse oximetry screening of newborns: Not just a screening test for congenital heart disease Gary F Sholler Director of Cardiac Services, Sydney Children’s Hospitals Network, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia
A strong argument is being made internationally for pulse oximetry newborn screening to be introduced for early diagnosis of major congenital heart disease (mCHD) in the newborn; however, despite its importance, this may be too narrow a perspective. Pulse oximetry can identify newborns with some (but not all) forms of mCHD.1–3 Early diagnosis also reduces morbidity and mortality in some mCHD lesion groups.4 Several studies have now confirmed that screening patients in their newborn populations identifies mCHD prior to the onset of symptoms in some. The benefits of early diagnosis are already well demonstrated in the literature reviewing outcomes after prenatal detection of mCHD with obstetric ultrasound and fetal cardiology input.4,5 The American Academy of Pediatrics have supported pulse oximetry screening for the identification of mCHD,3 and the US Department of Health and Human Services have recommended oximetry screening and tasked the CDC and NIH with responsibilities related to this. In May 2014, the CDC6 recommended that after a confirmed positive screening result, ‘any infant with a positive screen should have a diagnostic echocardiogram, which would involve an echocardiogram within the hospital or birthing center (sic), transport to another institution for the procedure, or use of telemedicine for remote evaluation’. This care cascade, also proposed in other publications, does not formally engage medical assessment and triage prior to echocardiography. Other factors will influence the applicability, efficacy and identification rate of a pulse oximetry screening programme. Locally, the likelihood of fetal diagnosis of major neonatal cardiac lesions exceeds 60% in many Australian states,4,7 reducing the chance of an undiagnosed newborn presentation of mCHD. The case identification rate in most reported series suggests that the additional load for paediatric cardiology programmes is small.8,9 The identification rate of mCHD in the paper by Bhola et al.9 is 0.02%. Further, to satisfy the Wilson and Junger criteria10 for screening, for other countries and communities practical considerations will come into play. These include the distances and resources involved in transfer after a positive finding, the availability of reliable oximeters, expert neonatal Correspondence: A/Prof Gary F Sholler, Heart Centre for Children and Adolph Basser Cardiac Institute, The Children’s Hospital at Westmead, Locked Bag 4001, Westmead, NSW 2145, Australia. Fax: 61 2 9845 2163; email: [email protected] Conflict of interest: None. Accepted for publication 17 June 2014.
864
cardiac imaging, cardiac assessment, and, in some countries with limited resources, downstream treatment options. Families value the confidence that a major abnormality may be identified early; however, for those babies with false positives and possible relocation of infants for additional assessment, this may be associated with important issues of parental anxiety and consequential impacts on bonding.4,11,12 It is also imperative that programmes involved with oximetry screening make it clear to parents and professionals that a negative test does not rule out all serious illness. For example, some cardiac lesions may not be associated with desaturation early (e.g. tetralogy of Fallot) or not at all (e.g. later onset coarctation of the aorta, significant but not critical aortic stenosis, ventricular septal defect, etc.). This clarity should minimise the risk of late presentation based on parental misunderstanding regarding the certainty of oximetry screening. The paper by Bhola et al.9 not only offers further confirmation of the efficacy of newborn pulse oximetry screening but also offers a variation on some published triage paths. Importantly, the authors highlight the benefits of early diagnosis of significant, non-cardiac illness and propose that a positive result is not an immediate trigger for echocardiography but rather should prompt careful, expert medical evaluation. Expanding the longstanding strategies of vital signs assessment for newborns (pulse, respiration, temperature) to include oximetry could be seen more as an augmented ‘well-being evaluation’, with the associated significant benefit of identifying some forms of mCHD. The authors also recommend clinical review as part of the triage process, which should allow for early and appropriate initiation of treatment for non-cardiac disease and should minimise unnecessary patient transfers. Whether or not oximetry should be deemed screening or part of augmented vital sign evaluation remains an open question. If it is considered in the context of screening, the identification of all illnesses (cardiac and non-cardiac) in Bhola et al.9 is 0.08% and approximates the projected rate of identification of about 0.1% in current NHMRC Australian newborn screening.13 Irrespective of the institution of statewide or national screening, several large Australian obstetric centres have already developed neonatal oximetry programmes.9 Caution will also be needed to avoid resource deployment away from important prenatal diagnosis strategies to post-natal screening programmes. Adding oximetry as an additional means of expanded vital sign evaluation of newborn well-being is sensible and will identify some cases of newborn mCHD prior to decompensation. Recognising oximetry to be more than just screening for mCHD
Journal of Paediatrics and Child Health 50 (2014) 864–865 © 2014 The Author Journal of Paediatrics and Child Health © 2014 Paediatrics and Child Health Division (Royal Australasian College of Physicians).
GF Sholler
not only permits sicker newborns with other conditions to benefit from early treatment but also ameliorates the impact for families carried by the stigma of oximetry being a cardiac investigation whilst offering the same benefits. Careful evaluation of the costs, manpower, expertise and tools is still required before wholesale Australian screening can be implemented; however, collaborative development of region-appropriate protocols is important and should involve relevant medical and nursing disciplines and government public health agencies. Tertiary cardiac programmes, especially given local Australasian prenatal detection rates for mCHD, are not likely to see a major impact but will see a substitution of a small additional inflow of stable newborns with cardiac abnormality, rather than unstable babies with late recognition of their lesion.
References 1 Beissel DJ, Goetz EM, Hokanson JS. Pulse oximetry screening in Wisconsin. Congenit. Heart Dis. 2012; 7: 460–5. 2 Ewer AK, Middleton LJ, Furmston AT et al. Pulse oximetry screening for congenital heart defects in newborn infants (PulseOx): a test accuracy study. Lancet 2011; 378: 785–94. 3 Mahle WT, Martin GR, Beekman RH III et al. Endorsement of health and human services recommendation for pulse oximetry screening for critical congenital heart disease. Pediatrics 2012; 129: 190–2. 4 Sholler GF, Kasparian NA, Pye VE, Cole AD, Winlaw DS. Fetal and post-natal diagnosis of major congenital heart disease: implications for medical and psychological care in the current era. J. Paediatr. Child Health 2011; 47: 717–22.
Pulse oximetry screening for newborns
5 Sivarajan V, Penny DJ, Filan P, Brizard C, Shekerdemian LS. Impact of antenatal diagnosis of hypoplastic left heart syndrome on the clinical presentation and surgical outcomes: the Australian experience. J. Paediatr. Child Health 2009; 45: 112–17. 6 Centre for Disease Control and Prevention. Screening for Critical Congenital Heart Defects. Centre for Disease Control and Prevention, 2013. Available from: http://www.cdc.gov/ncbddd/pediatricgenetics/ pulse.html [accessed May 2014]. 7 Soszyn N. Current Victorian antenatal detection rates of congenital heart disease in infancy. World Congress of Cardiology; May 5, 2014; Melbourne, 2014. 8 Singh A, Ewer AK. Pulse oximetry screening for critical congenital heart defects: a UK national survey. Lancet 2013; 381: 535. 9 Bhola K, Evans N, Kluckow M. Post-implementation review of pulse oximetry screening of well newborns in an Australian tertiary maternity hospital. J. Paediatr. Child Health 2014; doi:10.1111/jpc.12651. [Epub ahead of print] 10 Wilson JM, Jungner YG. [Principles and practice of mass screening for disease]. Bol. Oficina Sanit. Panam. 1968; 65: 281–393. 11 Kasparian NA, Fidock B, Sholler GF et al. Parents’ perceptions of genetics services for congenital heart disease: the role of demographic, clinical, and psychological factors in determining service attendance. Genet. Med. 2014; 16: 460–8. 12 Rychik J, Donaghue DD, Levy S et al. Maternal psychological stress after prenatal diagnosis of congenital heart disease. J. Pediatr. 2013; 162: 302–7. 13 National Health and Medical Research Council. Genetics in Family Medicine: The Australian Handbook for General Practitioners. Australia: National Health and Medical Research Council, 2007; 1–13. Available from: http://www.nhmrc.gov.au/_files_nhmrc/file/ your_health/egenetics/genetics_in_family_mdicine.pdf [accessed May 2014].
Journal of Paediatrics and Child Health 50 (2014) 864–865 © 2014 The Author Journal of Paediatrics and Child Health © 2014 Paediatrics and Child Health Division (Royal Australasian College of Physicians)
865
Copyright of Journal of Paediatrics & Child Health is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
doi:10.1111/jpc.12755
VIEWPOINT
Pulse oximetry screening of newborns: Not just a screening test for congenital heart disease Gary F Sholler Director of Cardiac Services, Sydney Children’s Hospitals Network, Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia
A strong argument is being made internationally for pulse oximetry newborn screening to be introduced for early diagnosis of major congenital heart disease (mCHD) in the newborn; however, despite its importance, this may be too narrow a perspective. Pulse oximetry can identify newborns with some (but not all) forms of mCHD.1–3 Early diagnosis also reduces morbidity and mortality in some mCHD lesion groups.4 Several studies have now confirmed that screening patients in their newborn populations identifies mCHD prior to the onset of symptoms in some. The benefits of early diagnosis are already well demonstrated in the literature reviewing outcomes after prenatal detection of mCHD with obstetric ultrasound and fetal cardiology input.4,5 The American Academy of Pediatrics have supported pulse oximetry screening for the identification of mCHD,3 and the US Department of Health and Human Services have recommended oximetry screening and tasked the CDC and NIH with responsibilities related to this. In May 2014, the CDC6 recommended that after a confirmed positive screening result, ‘any infant with a positive screen should have a diagnostic echocardiogram, which would involve an echocardiogram within the hospital or birthing center (sic), transport to another institution for the procedure, or use of telemedicine for remote evaluation’. This care cascade, also proposed in other publications, does not formally engage medical assessment and triage prior to echocardiography. Other factors will influence the applicability, efficacy and identification rate of a pulse oximetry screening programme. Locally, the likelihood of fetal diagnosis of major neonatal cardiac lesions exceeds 60% in many Australian states,4,7 reducing the chance of an undiagnosed newborn presentation of mCHD. The case identification rate in most reported series suggests that the additional load for paediatric cardiology programmes is small.8,9 The identification rate of mCHD in the paper by Bhola et al.9 is 0.02%. Further, to satisfy the Wilson and Junger criteria10 for screening, for other countries and communities practical considerations will come into play. These include the distances and resources involved in transfer after a positive finding, the availability of reliable oximeters, expert neonatal Correspondence: A/Prof Gary F Sholler, Heart Centre for Children and Adolph Basser Cardiac Institute, The Children’s Hospital at Westmead, Locked Bag 4001, Westmead, NSW 2145, Australia. Fax: 61 2 9845 2163; email: [email protected] Conflict of interest: None. Accepted for publication 17 June 2014.
864
cardiac imaging, cardiac assessment, and, in some countries with limited resources, downstream treatment options. Families value the confidence that a major abnormality may be identified early; however, for those babies with false positives and possible relocation of infants for additional assessment, this may be associated with important issues of parental anxiety and consequential impacts on bonding.4,11,12 It is also imperative that programmes involved with oximetry screening make it clear to parents and professionals that a negative test does not rule out all serious illness. For example, some cardiac lesions may not be associated with desaturation early (e.g. tetralogy of Fallot) or not at all (e.g. later onset coarctation of the aorta, significant but not critical aortic stenosis, ventricular septal defect, etc.). This clarity should minimise the risk of late presentation based on parental misunderstanding regarding the certainty of oximetry screening. The paper by Bhola et al.9 not only offers further confirmation of the efficacy of newborn pulse oximetry screening but also offers a variation on some published triage paths. Importantly, the authors highlight the benefits of early diagnosis of significant, non-cardiac illness and propose that a positive result is not an immediate trigger for echocardiography but rather should prompt careful, expert medical evaluation. Expanding the longstanding strategies of vital signs assessment for newborns (pulse, respiration, temperature) to include oximetry could be seen more as an augmented ‘well-being evaluation’, with the associated significant benefit of identifying some forms of mCHD. The authors also recommend clinical review as part of the triage process, which should allow for early and appropriate initiation of treatment for non-cardiac disease and should minimise unnecessary patient transfers. Whether or not oximetry should be deemed screening or part of augmented vital sign evaluation remains an open question. If it is considered in the context of screening, the identification of all illnesses (cardiac and non-cardiac) in Bhola et al.9 is 0.08% and approximates the projected rate of identification of about 0.1% in current NHMRC Australian newborn screening.13 Irrespective of the institution of statewide or national screening, several large Australian obstetric centres have already developed neonatal oximetry programmes.9 Caution will also be needed to avoid resource deployment away from important prenatal diagnosis strategies to post-natal screening programmes. Adding oximetry as an additional means of expanded vital sign evaluation of newborn well-being is sensible and will identify some cases of newborn mCHD prior to decompensation. Recognising oximetry to be more than just screening for mCHD
Journal of Paediatrics and Child Health 50 (2014) 864–865 © 2014 The Author Journal of Paediatrics and Child Health © 2014 Paediatrics and Child Health Division (Royal Australasian College of Physicians).
GF Sholler
not only permits sicker newborns with other conditions to benefit from early treatment but also ameliorates the impact for families carried by the stigma of oximetry being a cardiac investigation whilst offering the same benefits. Careful evaluation of the costs, manpower, expertise and tools is still required before wholesale Australian screening can be implemented; however, collaborative development of region-appropriate protocols is important and should involve relevant medical and nursing disciplines and government public health agencies. Tertiary cardiac programmes, especially given local Australasian prenatal detection rates for mCHD, are not likely to see a major impact but will see a substitution of a small additional inflow of stable newborns with cardiac abnormality, rather than unstable babies with late recognition of their lesion.
References 1 Beissel DJ, Goetz EM, Hokanson JS. Pulse oximetry screening in Wisconsin. Congenit. Heart Dis. 2012; 7: 460–5. 2 Ewer AK, Middleton LJ, Furmston AT et al. Pulse oximetry screening for congenital heart defects in newborn infants (PulseOx): a test accuracy study. Lancet 2011; 378: 785–94. 3 Mahle WT, Martin GR, Beekman RH III et al. Endorsement of health and human services recommendation for pulse oximetry screening for critical congenital heart disease. Pediatrics 2012; 129: 190–2. 4 Sholler GF, Kasparian NA, Pye VE, Cole AD, Winlaw DS. Fetal and post-natal diagnosis of major congenital heart disease: implications for medical and psychological care in the current era. J. Paediatr. Child Health 2011; 47: 717–22.
Pulse oximetry screening for newborns
5 Sivarajan V, Penny DJ, Filan P, Brizard C, Shekerdemian LS. Impact of antenatal diagnosis of hypoplastic left heart syndrome on the clinical presentation and surgical outcomes: the Australian experience. J. Paediatr. Child Health 2009; 45: 112–17. 6 Centre for Disease Control and Prevention. Screening for Critical Congenital Heart Defects. Centre for Disease Control and Prevention, 2013. Available from: http://www.cdc.gov/ncbddd/pediatricgenetics/ pulse.html [accessed May 2014]. 7 Soszyn N. Current Victorian antenatal detection rates of congenital heart disease in infancy. World Congress of Cardiology; May 5, 2014; Melbourne, 2014. 8 Singh A, Ewer AK. Pulse oximetry screening for critical congenital heart defects: a UK national survey. Lancet 2013; 381: 535. 9 Bhola K, Evans N, Kluckow M. Post-implementation review of pulse oximetry screening of well newborns in an Australian tertiary maternity hospital. J. Paediatr. Child Health 2014; doi:10.1111/jpc.12651. [Epub ahead of print] 10 Wilson JM, Jungner YG. [Principles and practice of mass screening for disease]. Bol. Oficina Sanit. Panam. 1968; 65: 281–393. 11 Kasparian NA, Fidock B, Sholler GF et al. Parents’ perceptions of genetics services for congenital heart disease: the role of demographic, clinical, and psychological factors in determining service attendance. Genet. Med. 2014; 16: 460–8. 12 Rychik J, Donaghue DD, Levy S et al. Maternal psychological stress after prenatal diagnosis of congenital heart disease. J. Pediatr. 2013; 162: 302–7. 13 National Health and Medical Research Council. Genetics in Family Medicine: The Australian Handbook for General Practitioners. Australia: National Health and Medical Research Council, 2007; 1–13. Available from: http://www.nhmrc.gov.au/_files_nhmrc/file/ your_health/egenetics/genetics_in_family_mdicine.pdf [accessed May 2014].
Journal of Paediatrics and Child Health 50 (2014) 864–865 © 2014 The Author Journal of Paediatrics and Child Health © 2014 Paediatrics and Child Health Division (Royal Australasian College of Physicians)
865
Copyright of Journal of Paediatrics & Child Health is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use.
