European Journal of Haematology 92 (156–163)

ORIGINAL ARTICLE

Pulmonary involvement in patients with thrombotic thrombocytopenic purpura Timothy Nokes1, James N. George2,3, Sara K. Vesely3, Ahmed Awab1 1

Pulmonary Diseases, Critical Care & Sleep Medicine Section; 2Hematology-Oncology Section, Department of Medicine, College of Medicine, Oklahoma City, OK; 3Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA

Abstract Objectives: To determine the frequency of pulmonary involvement in patients with thrombotic thrombocytopenic purpura (TTP). Methods: The experience of the Oklahoma TTP-HUS (hemolytic–uremic syndrome) Registry, a population-based cohort of consecutive patients without selection or referral bias, 1995–2012, was analyzed. Evidence for pulmonary involvement in patients with TTP was also documented with a systematic review of published reports. Results: Only one of 74 Registry patients with acquired severe ADAMTS13 deficiency (activity