FEBS Letters 588 (2014) 205
journal homepage: www.FEBSLetters.org
Editorial
Protein Engineering The design, production, purification and optimization of modified proteins to answer specific biological requirements, a process commonly defined as Protein Engineering, has become a powerful tool for researchers interested in protein structure and function and the use of proteins for therapeutic purposes. Protein Engineering brings together molecular cell biological techniques and principles of organic chemistry to effectively design proteins and to efficiently fine tune their properties, such as stability, receptor and target recognition, folding, half life, enzyme activity, structure and synthetic production, according to requirement. The most frequent experimental strategies either utilize the detailed knowledge of protein structures or apply random mutagenesis followed by an appropriate selection process. Both these strategies are extensively described herewith. Specifically, this Special Issue deals with different lines of research focusing on questions related to protein structure (Dombkowski et al., Richter et al.), enzyme activity (Chen & Romesberg, Tanabe et al.), protein production (Lebendiker & Danieli, Hwang et al., Ashok et al., Rosenblum &
Cooperman), immuno-reagents (Rouet et al., Doerner et al., Ahmed & Cheung, Koellhoffer et al., Agrawal et al., Zhang et al., Weiss-Ottolenghi & Gershoni) and cancer therapy (Petrenko & Jayanna, Hong & Zeng, Zhang & Sidhu, Kyi & Postow, Feng & Ho). With a growing range of applications, and the onset of highthroughput technology, Protein Engineering is an ever-growing field that can not only deepen our understanding on the functions of natural proteins, but also leads to the development of artificial proteins modified for the benefit of human health. Reviews Editor Wilhelm Just FEBS Letters Editorial Office, University of Heidelberg, Im Neunheimer Feld 328, Germany Tel.: +49 6221 544286. E-mail address: [email protected]
0014-5793/$36.00 Ó 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. http://dx.doi.org/10.1016/j.febslet.2013.12.001
Available online 7 December 2013
journal homepage: www.FEBSLetters.org
Editorial
Protein Engineering The design, production, purification and optimization of modified proteins to answer specific biological requirements, a process commonly defined as Protein Engineering, has become a powerful tool for researchers interested in protein structure and function and the use of proteins for therapeutic purposes. Protein Engineering brings together molecular cell biological techniques and principles of organic chemistry to effectively design proteins and to efficiently fine tune their properties, such as stability, receptor and target recognition, folding, half life, enzyme activity, structure and synthetic production, according to requirement. The most frequent experimental strategies either utilize the detailed knowledge of protein structures or apply random mutagenesis followed by an appropriate selection process. Both these strategies are extensively described herewith. Specifically, this Special Issue deals with different lines of research focusing on questions related to protein structure (Dombkowski et al., Richter et al.), enzyme activity (Chen & Romesberg, Tanabe et al.), protein production (Lebendiker & Danieli, Hwang et al., Ashok et al., Rosenblum &
Cooperman), immuno-reagents (Rouet et al., Doerner et al., Ahmed & Cheung, Koellhoffer et al., Agrawal et al., Zhang et al., Weiss-Ottolenghi & Gershoni) and cancer therapy (Petrenko & Jayanna, Hong & Zeng, Zhang & Sidhu, Kyi & Postow, Feng & Ho). With a growing range of applications, and the onset of highthroughput technology, Protein Engineering is an ever-growing field that can not only deepen our understanding on the functions of natural proteins, but also leads to the development of artificial proteins modified for the benefit of human health. Reviews Editor Wilhelm Just FEBS Letters Editorial Office, University of Heidelberg, Im Neunheimer Feld 328, Germany Tel.: +49 6221 544286. E-mail address: [email protected]
0014-5793/$36.00 Ó 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. http://dx.doi.org/10.1016/j.febslet.2013.12.001
Available online 7 December 2013
