Iranian Journal of Basic Medical Sciences ijbms.mums.ac.ir
Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats Gholam Hossein Farjah 1*, Shadi Salehi 2, Mohammad Hasan Ansari 3, Bagher Pourheidar 1 1 Neurophysiology
Research Center, Department of Anatomy, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran of Medicine, Urmia University of Medical Sciences, Urmia, Iran 3 Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran 2 Faculty
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ABSTRACT
Article type:
Objective(s): Ischemia/reperfusion (I/R) injury of spinal cord is leading to the paraplegia observed. In this study, we investigated the protective effect of the saffron extract on spinal cord I/R injury. Materials and Methods: Thirty five male Sprague-Dawley rats were divided into 5 groups: intact, sham surgery, normal saline (NS), low dose saffron aqua extract, high dose saffron aqua extract. Results: The mean motor deficit index (MDI) scores were significantly lower in the saffron extract groups than in the NS group at 48 hr after spinal cord ischemia (P
Protective effect of Crocus sativus L. (Saffron) extract on spinal cord ischemia-reperfusion injury in rats Gholam Hossein Farjah 1*, Shadi Salehi 2, Mohammad Hasan Ansari 3, Bagher Pourheidar 1 1 Neurophysiology
Research Center, Department of Anatomy, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran of Medicine, Urmia University of Medical Sciences, Urmia, Iran 3 Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran 2 Faculty
ARTICLE INFO
ABSTRACT
Article type:
Objective(s): Ischemia/reperfusion (I/R) injury of spinal cord is leading to the paraplegia observed. In this study, we investigated the protective effect of the saffron extract on spinal cord I/R injury. Materials and Methods: Thirty five male Sprague-Dawley rats were divided into 5 groups: intact, sham surgery, normal saline (NS), low dose saffron aqua extract, high dose saffron aqua extract. Results: The mean motor deficit index (MDI) scores were significantly lower in the saffron extract groups than in the NS group at 48 hr after spinal cord ischemia (P
