Clinical Radiology xxx (2015) e1ee8

Contents lists available at ScienceDirect

Clinical Radiology journal homepage: www.clinicalradiologyonline.net

Prospective glioma grading using single-dose dynamic contrast-enhanced perfusion MRI K.K. Jain a, P. Sahoo b, R. Tyagi a, A. Mehta a, R. Patir c, S. Vaishya c, N. Prakash d, N. Vasudev d, R.K. Gupta a, * a

Department of Radiology and Imaging, Fortis Memorial Research Institute, Gurgaon, India Philips Healthcare, Philips India Ltd, Gurgaon, India c Neurosurgery, Fortis Memorial Research Institute, Gurgaon, India d Pathology, Fortis Memorial Research Institute, Gurgaon, India b

art icl e i nformat ion Article history: Received 10 February 2015 Received in revised form 31 March 2015 Accepted 1 June 2015

AIM: To evaluate the sensitivity and specificity of single-dose dynamic contrast-enhanced (DCE) perfusion magnetic resonance imaging (MRI) in prospective evaluation of glioma grading and to correlate the relative cerebral blood volume (rCBV) values with mitotic and ki67 indexes obtained at histopathology. MATERIALS AND METHODS: A total of 53 histologically proven patients with glioma were included in this study. DCE-MRI perfusion with a single dose of contrast medium was included in brain tumour protocol and prospective grading of glioma into low and high grade was done based on a previously reported rCBV cut-off value of 3. Tumours with rCBV
3 were considered to be high grade and rCBV