Surgical Neurology International

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Editor: James I. Ausman, MD, PhD University of California, Los Angeles, CA, USA

Original Article

Prognostic value of the preoperative immunological profile in patients with glioblastoma Konstantinos Gousias1,2, Spiridon Voulgaris2, Georgios Vartholomatos3, Paraskevi Voulgari4, Athanasios P. Kyritsis5, Markella Markou6 Departments of Neurosurgery, University Hospital of Bonn, Sigmund‑Freud‑Strasse 25, 53105, 6Psychiatry, Landschaftsverband Rheinland Klinik, Kaiser‑Karl‑Ring 20, Bonn, 53111, Germany, 2Neurosurgery, 3Haematology, 4Rheumatology and 5Neurology, University Hospital of Ioannina, 45500, Greece 1

E‑mail: *Konstantinos Gousias ‑ [email protected]‑bonn.de; Spiridon Voulgaris ‑ [email protected]; Georgios Vartholomatos ‑ [email protected]; Paraskevi Voulgari ‑ [email protected]; Athanasios P. Kyritsis ‑ [email protected]; Markella Markou ‑ [email protected] *Corresponding author Received: 19 March 14   Accepted: 10 April 14    Published: 07 June 14 This article may be cited as: Gousias K,Voulgaris S,Vartholomatos G,Voulgari P, Kyritsis AP, Markou M. Prognostic value of the preoperative immunological profile in patients with glioblastoma. Surg Neurol Int 2014;5:89. Available FREE in open access from: http://www.surgicalneurologyint.com/text.asp?2014/5/1/89/134104 Copyright: © 2014 Gousias K. This is an open‑access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract Background: Aim of our study was to determine the predictive impact of certain serum immunological markers on overall survival (OS) in patients with glioblastoma multiforme (GBM). Methods: We assayed prospectively values of interleukin 2 (IL‑2), immunoglobulin G  (IgG), C4, CD3+, CD4+  and CD8+  cells via flow cytometry, enzyme‑linked immunosorbent assay (ELISA)  and radial immunodiffusion in preoperative sera of adult patients with de novo histologically confirmed supratentorial GBM. KaplanMeier method and Cox proportional hazards models were used to assess clinical, laboratory, and treatment prognostic factors for OS. Results: Twenty‑six consecutive patients were identified with a mean age of 59.6 years. Median follow up was 12 months. Lower IL‑2 values (

Prognostic value of the preoperative immunological profile in patients with glioblastoma.

Aim of our study was to determine the predictive impact of certain serum immunological markers on overall survival (OS) in patients with glioblastoma ...
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