Int J Clin Exp Med 2015;8(8):12056-12063 www.ijcem.com /ISSN:1940-5901/IJCEM0008634
Original Article Prognostic value of melanoma cell adhesion molecule expression in cancers: a meta-analysis Guoqing Zhu1, Xiao Zhang1, Yulan Wang1, Huizi Xiong2, Yinghui Zhao1, Jiayi Wang1, Fenyong Sun1 Departments of 1Clinical Laboratory Medicine, 2Dermatology, Shanghai Tenth People’s Hospital of Tongji University, Shanghai 200072, China Received March 31, 2015; Accepted June 2, 2015; Epub August 15, 2015; Published August 30, 2015 Abstract: Melanoma cell adhesion molecule (MACM) has been reported in many studies as a novel bio-marker for its prognosis value in cancers. But the prognosis significance of MACM expression in cancer remains inconclusive. Therefore, we conducted a system review and meta-analysis to assess its prognosis value in cancers. A systematic search through Pubmed, EMBASE and Cochran Library database was conducted. Hazard Ratios (HRs) and 95% confidence intervals (CIs) were used to evaluate the prognosis value of MACM expression. Eleven studies with 2657 cases were included after sorting out 462 articles for this meta-analysis. The results of the fixed-model depending on the heterogeneity in studies demonstrated that MACM expression was significantly associated with overall survival (OS) in cancer (HR=2.84, 95% CI: 1.10-7.31, P
Original Article Prognostic value of melanoma cell adhesion molecule expression in cancers: a meta-analysis Guoqing Zhu1, Xiao Zhang1, Yulan Wang1, Huizi Xiong2, Yinghui Zhao1, Jiayi Wang1, Fenyong Sun1 Departments of 1Clinical Laboratory Medicine, 2Dermatology, Shanghai Tenth People’s Hospital of Tongji University, Shanghai 200072, China Received March 31, 2015; Accepted June 2, 2015; Epub August 15, 2015; Published August 30, 2015 Abstract: Melanoma cell adhesion molecule (MACM) has been reported in many studies as a novel bio-marker for its prognosis value in cancers. But the prognosis significance of MACM expression in cancer remains inconclusive. Therefore, we conducted a system review and meta-analysis to assess its prognosis value in cancers. A systematic search through Pubmed, EMBASE and Cochran Library database was conducted. Hazard Ratios (HRs) and 95% confidence intervals (CIs) were used to evaluate the prognosis value of MACM expression. Eleven studies with 2657 cases were included after sorting out 462 articles for this meta-analysis. The results of the fixed-model depending on the heterogeneity in studies demonstrated that MACM expression was significantly associated with overall survival (OS) in cancer (HR=2.84, 95% CI: 1.10-7.31, P
