Original Article http://dx.doi.org/10.4070/kcj.2016.46.2.154 Print ISSN 1738-5520 • On-line ISSN 1738-5555
Korean Circulation Journal
Prognostic Value of Elevated Homocysteine Levels in Korean Patients with Coronary Artery Disease: A Propensity Score Matched Analysis Sung Woo Kwon, MD1, 2, Jong-Youn Kim, MD3, Young Ju Suh, PhD4, Dae Hyung Lee, MS5, Young Won Yoon, MD3, Byoung Kwon Lee, MD3, Young-Hak Jung, MD3, Eui-Young Choi, MD3, Bum-Kee Hong, MD3, Se-Joong Rim, MD3, and Hyuck Moon Kwon, MD3 1
Department of Cardiology, Inha University Hospital, Incheon,
2
Department of Medicine, Yonsei University Graduate School, Seoul,
3
Department of Cardiology and Cardiovascular Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul,
4
Clinical Research Institute, Inha University School of Medicine, Incheon,
5
Future Strategy, Inha University Hospital, Incheon, Korea
Background and Objectives: We sought to determine whether an elevated homocysteine (Hcy) level is associated with a worse prognosis in Korean patients with coronary artery disease (CAD). Subjects and Methods: A total of 5839 patients (60.4% male, mean age 61.3±11.2 years) with CAD were enrolled from 2000 to 2010 at Gangnam Severance Hospital. CAD was diagnosed by invasive coronary angiography. Laboratory values including Hcy level were obtained on the day of coronary angiography and analyses were performed shortly after sampling. Patients were divided into two groups according to their Hcy levels. Baseline risk factors, coronary angiographic findings, length of follow-up, and composite endpoints including cardiac death (CD) and non-fatal myocardial infarction (NFMI) were recorded. 1:1 propensity score matched analysis was also performed. Results: Over a mean follow-up period of 4.4±2.5 years, there were 132 composite endpoints (75 CD and 57 NFMI) with an event rate of 2.3%. Mean Hcy level was 9.9±4.3 μmol/L (normal Hcy 7.9±1.5 μmol/L and elevated Hcy 13.9±5.1 μmol/L). Kaplan-Meier survival analysis showed an association of elevated Hcy level with worse prognosis (p
Korean Circulation Journal
Prognostic Value of Elevated Homocysteine Levels in Korean Patients with Coronary Artery Disease: A Propensity Score Matched Analysis Sung Woo Kwon, MD1, 2, Jong-Youn Kim, MD3, Young Ju Suh, PhD4, Dae Hyung Lee, MS5, Young Won Yoon, MD3, Byoung Kwon Lee, MD3, Young-Hak Jung, MD3, Eui-Young Choi, MD3, Bum-Kee Hong, MD3, Se-Joong Rim, MD3, and Hyuck Moon Kwon, MD3 1
Department of Cardiology, Inha University Hospital, Incheon,
2
Department of Medicine, Yonsei University Graduate School, Seoul,
3
Department of Cardiology and Cardiovascular Center, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul,
4
Clinical Research Institute, Inha University School of Medicine, Incheon,
5
Future Strategy, Inha University Hospital, Incheon, Korea
Background and Objectives: We sought to determine whether an elevated homocysteine (Hcy) level is associated with a worse prognosis in Korean patients with coronary artery disease (CAD). Subjects and Methods: A total of 5839 patients (60.4% male, mean age 61.3±11.2 years) with CAD were enrolled from 2000 to 2010 at Gangnam Severance Hospital. CAD was diagnosed by invasive coronary angiography. Laboratory values including Hcy level were obtained on the day of coronary angiography and analyses were performed shortly after sampling. Patients were divided into two groups according to their Hcy levels. Baseline risk factors, coronary angiographic findings, length of follow-up, and composite endpoints including cardiac death (CD) and non-fatal myocardial infarction (NFMI) were recorded. 1:1 propensity score matched analysis was also performed. Results: Over a mean follow-up period of 4.4±2.5 years, there were 132 composite endpoints (75 CD and 57 NFMI) with an event rate of 2.3%. Mean Hcy level was 9.9±4.3 μmol/L (normal Hcy 7.9±1.5 μmol/L and elevated Hcy 13.9±5.1 μmol/L). Kaplan-Meier survival analysis showed an association of elevated Hcy level with worse prognosis (p
