European Heart Journal: Acute Cardiovascular Care http://acc.sagepub.com/
Prognostic impact of atrial fibrillation in acute coronary syndromes: results from the ARIAM registry Manuel Almendro-Delia, María José Valle-Caballero, Juan C Garcia-Rubira, Blanca Muñoz-Calero, Angel Garcia-Alcantara, Antonio Reina-Toral, José Benítez-Parejo, Rafael Hidalgo-Urbano and on behalf of the ARIAM Andalucia Study Group European Heart Journal: Acute Cardiovascular Care 2014 3: 141 originally published online 17 December 2013 DOI: 10.1177/2048872613517370 The online version of this article can be found at: http://acc.sagepub.com/content/3/2/141
Published by: European Society of Cardiology
ESC Working Group on Acute Cardiac Care
and http://www.sagepublications.com
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517370 research-article2013
ACC0010.1177/2048872613517370European Heart Journal: Acute Cardiovascular CareAlmendro-Delia et al.
EUROPEAN SOCIETY OF CARDIOLOGY ®
Original scientific paper
European Heart Journal: Acute Cardiovascular Care 2014, Vol. 3(2) 141–148 © The European Society of Cardiology 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav DOI: 10.1177/2048872613517370 acc.sagepub.com
Prognostic impact of atrial fibrillation in acute coronary syndromes: results from the ARIAM registry
Manuel Almendro-Delia1,*, María José Valle-Caballero1,*, Juan C Garcia-Rubira1, Blanca Muñoz-Calero1, Angel Garcia-Alcantara2, Antonio Reina-Toral3, José Benítez-Parejo4 and Rafael HidalgoUrbano1; on behalf of the ARIAM Andalucia Study Group
Abstract Aims: The prognostic ability of atrial fibrillation (AF) in acute coronary syndromes (ACS) is unclear. Studies regarding patient outcomes with respect to the timing of AF are scarce and conflicting. The present study aimed to determine the frequency, predictors and impact on clinical outcome of AF in patients with ACS. Methods: We analysed 39,237 consecutive patients with ACS included in the ARIAM registry between January /2001 and December 2011. Patients with AF were compared with patients in sinus rhythm. We differentiate between new-onset AF and previous AF cases to analyse mortality and other major adverse cardiac events (MACE) during hospitalization. Results: Of the patients, 2851 (7.3%) developed AF; 1568 (55%) of these were new-onset AF and 1283 (45%) had previous AF. The AF group had a higher risk profile at baseline and poorer clinical presentation at admission than non-AF patients. Compared with previous AF patients, new-onset AF presented with fewer comorbidities, including hypertension, diabetes, prior myocardial infarction, and chronic renal impairment. The inhospital mortality for newonset AF, previous AF, and non-AF patients were 14, 11.6, and 5.2%, respectively (new-onset AF unadjusted HR 2.19, 95% CI 1.9–2.53, p
Prognostic impact of atrial fibrillation in acute coronary syndromes: results from the ARIAM registry Manuel Almendro-Delia, María José Valle-Caballero, Juan C Garcia-Rubira, Blanca Muñoz-Calero, Angel Garcia-Alcantara, Antonio Reina-Toral, José Benítez-Parejo, Rafael Hidalgo-Urbano and on behalf of the ARIAM Andalucia Study Group European Heart Journal: Acute Cardiovascular Care 2014 3: 141 originally published online 17 December 2013 DOI: 10.1177/2048872613517370 The online version of this article can be found at: http://acc.sagepub.com/content/3/2/141
Published by: European Society of Cardiology
ESC Working Group on Acute Cardiac Care
and http://www.sagepublications.com
Additional services and information for European Heart Journal: Acute Cardiovascular Care can be found at: Email Alerts: http://acc.sagepub.com/cgi/alerts Subscriptions: http://acc.sagepub.com/subscriptions Reprints: http://www.sagepub.com/journalsReprints.nav Permissions: http://www.sagepub.com/journalsPermissions.nav
>> Version of Record - May 2, 2014 OnlineFirst Version of Record - Dec 17, 2013 What is This?
Downloaded from acc.sagepub.com by guest on November 23, 2014
517370 research-article2013
ACC0010.1177/2048872613517370European Heart Journal: Acute Cardiovascular CareAlmendro-Delia et al.
EUROPEAN SOCIETY OF CARDIOLOGY ®
Original scientific paper
European Heart Journal: Acute Cardiovascular Care 2014, Vol. 3(2) 141–148 © The European Society of Cardiology 2013 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav DOI: 10.1177/2048872613517370 acc.sagepub.com
Prognostic impact of atrial fibrillation in acute coronary syndromes: results from the ARIAM registry
Manuel Almendro-Delia1,*, María José Valle-Caballero1,*, Juan C Garcia-Rubira1, Blanca Muñoz-Calero1, Angel Garcia-Alcantara2, Antonio Reina-Toral3, José Benítez-Parejo4 and Rafael HidalgoUrbano1; on behalf of the ARIAM Andalucia Study Group
Abstract Aims: The prognostic ability of atrial fibrillation (AF) in acute coronary syndromes (ACS) is unclear. Studies regarding patient outcomes with respect to the timing of AF are scarce and conflicting. The present study aimed to determine the frequency, predictors and impact on clinical outcome of AF in patients with ACS. Methods: We analysed 39,237 consecutive patients with ACS included in the ARIAM registry between January /2001 and December 2011. Patients with AF were compared with patients in sinus rhythm. We differentiate between new-onset AF and previous AF cases to analyse mortality and other major adverse cardiac events (MACE) during hospitalization. Results: Of the patients, 2851 (7.3%) developed AF; 1568 (55%) of these were new-onset AF and 1283 (45%) had previous AF. The AF group had a higher risk profile at baseline and poorer clinical presentation at admission than non-AF patients. Compared with previous AF patients, new-onset AF presented with fewer comorbidities, including hypertension, diabetes, prior myocardial infarction, and chronic renal impairment. The inhospital mortality for newonset AF, previous AF, and non-AF patients were 14, 11.6, and 5.2%, respectively (new-onset AF unadjusted HR 2.19, 95% CI 1.9–2.53, p
