pISSN : 2093-582X, eISSN : 2093-5641 J Gastric Cancer 2016;16(1):21-27 http://dx.doi.org/10.5230/jgc.2016.16.1.21
Original Article
Prognostic and Clinicopathological Significance of TransducerLike Enhancer of Split 1 Expression in Gastric Cancer Ji-Hye Lee, Myoung-Won Son1, Kyung-Ju Kim, Mee-Hye Oh, Hyundeuk Cho2, Hyun Ju Lee, Si-Hyong Jang, and Moon Soo Lee1 Departments of Pathology and 1General Surgery, Soonchunhyang University Cheonan Hospital, 3 Department of Pathology, Soonchunhyang University College of Medicine, Cheonan, Korea
Purpose: Transducer-like enhancer of split 1 (TLE1) is a member of the Groucho/TLE family of transcriptional co-repressors that regulate the transcriptional activity of numerous genes. TLE1 is involved in the tumorigenesis of various tumors. We investigated the prognostic significance of TLE1 expression and its association with clinicopathological parameters in gastric cancer (GC) patients. Materials and Methods: Immunohistochemical analysis of six tissue microarrays was performed to examine TLE1 expression using 291 surgically resected GC specimens from the Soonchunhyang University Cheonan Hospital between July 2006 and December 2009. Results: In the non-neoplastic gastric mucosa, TLE1 expression was negative. In GC, 121 patients (41.6%) were positive for TLE1. The expression of TLE1 was significantly associated with male gender (P=0.021), less frequent lymphatic (P=0.017) or perineural invasion (P=0.029), intestinal type according to the Lauren classification (P=0.024), good histologic grade (P
Original Article
Prognostic and Clinicopathological Significance of TransducerLike Enhancer of Split 1 Expression in Gastric Cancer Ji-Hye Lee, Myoung-Won Son1, Kyung-Ju Kim, Mee-Hye Oh, Hyundeuk Cho2, Hyun Ju Lee, Si-Hyong Jang, and Moon Soo Lee1 Departments of Pathology and 1General Surgery, Soonchunhyang University Cheonan Hospital, 3 Department of Pathology, Soonchunhyang University College of Medicine, Cheonan, Korea
Purpose: Transducer-like enhancer of split 1 (TLE1) is a member of the Groucho/TLE family of transcriptional co-repressors that regulate the transcriptional activity of numerous genes. TLE1 is involved in the tumorigenesis of various tumors. We investigated the prognostic significance of TLE1 expression and its association with clinicopathological parameters in gastric cancer (GC) patients. Materials and Methods: Immunohistochemical analysis of six tissue microarrays was performed to examine TLE1 expression using 291 surgically resected GC specimens from the Soonchunhyang University Cheonan Hospital between July 2006 and December 2009. Results: In the non-neoplastic gastric mucosa, TLE1 expression was negative. In GC, 121 patients (41.6%) were positive for TLE1. The expression of TLE1 was significantly associated with male gender (P=0.021), less frequent lymphatic (P=0.017) or perineural invasion (P=0.029), intestinal type according to the Lauren classification (P=0.024), good histologic grade (P
