202

4TH ANNUAL MEETING, HEIDELBERG

modal numbers and karyotypes are similar. Neither is there any difference in anlount> of DNA repair replication after treatment of the two cell lines with sulphur mustard. Lesions that give rise to chromosoinal aberrations inav be different from, or represent only a small proportion of, those that elicit repair replication. Other repair (or lnisrepair) processes m a y be involved in aberration formation. Tile same pair of Yoshida cell lines showed equal survival, chromosome damage and DNA repair replication after X-irradiation.

13 STEGNER, [., AND A. HERWIG, Institut ftir Anthropologie und Humangenetik der Universit~it Heidelberg, 69 Heidelberg I, Neuenheimer Feld 328 (West-Germany).

Comparative mutagenicity test of three cyclophosphamides in the bone ma rrow of Chinese hamsters ( Cricetulus griseus) During two experimental set-ups, dose dependency and time dependency of induced chromosomal aberrations were tested after i.p. application of three cyclophosphamides. The substances analysed in the bone marrow of Chinese hamsters were Cytoxan, Trofosfamide and Isofosfanfide. Two applications were made with an interval of 24 tl. The bone marrow was prepared 6, I2, 24 and 48 h after tile second application. Doses of I/3O, 3/3 o and 9/30 of LDs0 were used. With cytoxan a linear dose-dependency was observed. Concerning time dependency we observed that tile mutation rate decreased to the control level within 48 1,. This work was sponsored by the Deutsche Forschungsgemeinschaft.

Proceedings: Comparative mutagenicity test of three cyclophosphamides in the bone marrow of Chinese hamsters (Cricetulus griseus).

202 4TH ANNUAL MEETING, HEIDELBERG modal numbers and karyotypes are similar. Neither is there any difference in anlount> of DNA repair replication a...
35KB Sizes 0 Downloads 0 Views