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PICTURES IN CLINICAL MEDICINE
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Primary Lung Sebaceous Carcinoma Tetsuya Hanaka 1,2, Kosuke Makihara 3, Yasutaka Hachiya 4 and Hiroshi Mukae 2 Key words: sebaceous carcinoma, oil red O stain, epithelial membrane antigen, operation, chemotherapy (Intern Med 54: 351-352, 2015) (DOI: 10.2169/internalmedicine.54.3339)
100 μm
Picture.
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Department of Respiratory Medicine, Kyushu Rosai Hospital, Japan, ２Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, ３Department of Surgical Pathology, Kyushu Rosai Hospital, Japan and ４Department of Surgery, Kyushu Rosai Hospital, Japan Received for publication May 23, 2014; Accepted for publication May 29, 2014 Correspondence to Dr. Hiroshi Mukae, [email protected]
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Intern Med 54: 351-352, 2015
DOI: 10.2169/internalmedicine.54.3339
A 75-year-old Japanese man with a one-month history of a productive cough was admitted to our hospital. Chest computed tomography showed a mass shadow in S6 of the right lung (Picture A). The patient underwent lobectomy for cT2aN1M0, stage IIA primary lung cancer in the right lower lobe. The macroscopic findings showed that the tumor grew circumferentially around the bronchial wall (Picture B). The tumor cells were histologically vacuolated (Picture C), histochemically positive for oil red O staining (Picture D) and negative for periodic acid-Schiff and mucicarmine staining and immunohistochemically positive for epithelial membrane antigens. Therefore, the tumor was diagnosed to be sebaceous carcinoma. The patient ultimately died due to disease progression five months after surgery, despite receiving post-
operative chemotherapy. Sebaceous carcinoma normally occurs in the eyelid (1), with only one case of primary lung sebaceous carcinoma having been reported to date (2). This is the first such case reported in Japan. The authors state that they have no Conflict of Interest (COI).
References 1. Dasgupta T, Wilson LD, Yu JB. A retrospective review of 1349 cases of sebaceous carcinoma. Cancer 115: 158-165, 2009. 2. Borczuk AC, Sha KK, Hisler SE, Mann JM, Hajdu SI. Sebaceous carcinoma of the lung: histologic and immunohistochemical characterization of an unusual pulmonary neoplasm. Am J Surg Pathol 26: 795-798, 2002.
Ⓒ 2015 The Japanese Society of Internal Medicine http://www.naika.or.jp/imonline/index.html
352
PICTURES IN CLINICAL MEDICINE
□
Primary Lung Sebaceous Carcinoma Tetsuya Hanaka 1,2, Kosuke Makihara 3, Yasutaka Hachiya 4 and Hiroshi Mukae 2 Key words: sebaceous carcinoma, oil red O stain, epithelial membrane antigen, operation, chemotherapy (Intern Med 54: 351-352, 2015) (DOI: 10.2169/internalmedicine.54.3339)
100 μm
Picture.
１
Department of Respiratory Medicine, Kyushu Rosai Hospital, Japan, ２Department of Respiratory Medicine, University of Occupational and Environmental Health, Japan, ３Department of Surgical Pathology, Kyushu Rosai Hospital, Japan and ４Department of Surgery, Kyushu Rosai Hospital, Japan Received for publication May 23, 2014; Accepted for publication May 29, 2014 Correspondence to Dr. Hiroshi Mukae, [email protected]
351
Intern Med 54: 351-352, 2015
DOI: 10.2169/internalmedicine.54.3339
A 75-year-old Japanese man with a one-month history of a productive cough was admitted to our hospital. Chest computed tomography showed a mass shadow in S6 of the right lung (Picture A). The patient underwent lobectomy for cT2aN1M0, stage IIA primary lung cancer in the right lower lobe. The macroscopic findings showed that the tumor grew circumferentially around the bronchial wall (Picture B). The tumor cells were histologically vacuolated (Picture C), histochemically positive for oil red O staining (Picture D) and negative for periodic acid-Schiff and mucicarmine staining and immunohistochemically positive for epithelial membrane antigens. Therefore, the tumor was diagnosed to be sebaceous carcinoma. The patient ultimately died due to disease progression five months after surgery, despite receiving post-
operative chemotherapy. Sebaceous carcinoma normally occurs in the eyelid (1), with only one case of primary lung sebaceous carcinoma having been reported to date (2). This is the first such case reported in Japan. The authors state that they have no Conflict of Interest (COI).
References 1. Dasgupta T, Wilson LD, Yu JB. A retrospective review of 1349 cases of sebaceous carcinoma. Cancer 115: 158-165, 2009. 2. Borczuk AC, Sha KK, Hisler SE, Mann JM, Hajdu SI. Sebaceous carcinoma of the lung: histologic and immunohistochemical characterization of an unusual pulmonary neoplasm. Am J Surg Pathol 26: 795-798, 2002.
Ⓒ 2015 The Japanese Society of Internal Medicine http://www.naika.or.jp/imonline/index.html
352
