Menopause: The Journal of The North American Menopause Society Vol. 22, No. 6, pp. 667/673 DOI: 10.1097/gme.0000000000000352 * 2014 by The North American Menopause Society
Prevalence of nonalcoholic fatty liver disease and its metabolic risk factors in women of different ages and body mass index Zhongli Wang, MD, PhD,1 Ming Xu, MD,1 Zhengguo Hu, MD,1 and Umid Kumar Shrestha, MD, PhD2 Abstract Objective: This study aims to investigate the prevalence of nonalcoholic fatty liver disease (NAFLD), to determine the metabolic risk factors of this disease, and to predict nonalcoholic steatohepatitis (NASH) with liver fibrosis in women of different ages and body mass index (BMI). Methods: In 2010-2011, a cross-sectional survey was conducted among 9,360 women at the health checkup center of Zhongnan Hospital (Wuhan, China). The probability of NASH with liver fibrosis was predicted using BAAT (BMI, age, alanine aminotransferase, and triglycerides) score. Results: The prevalence of NAFLD increased from 5.3% to 18.8% in women younger than 45 years versus women aged 45 to 55 years and rose to 27.8% in women older than 55 years. In obese women, the prevalence of NAFLD was 48.4%. Women older than 45 years and obese women with NAFLD had more unfavorable metabolic risk factors. Multiple regression analyses showed that increased BMI and low aspartate aminotransferaseYtoYalanine aminotransferase ratio were closely related to NAFLD in women of different ages, whereas increasing BMI, BAAT score, age, high triglycerides, alanine aminotransferase, and low aspartate aminotransferaseYtoYalanine aminotransferase ratio were all closely related to NAFLD in obese women. The prevalence of NASH with a BAAT index of 3 or higher was 13.2% and 14.9% in women older than 55 years and obese women with NAFLD, respectively. Conclusions: Obese and postmenopausal women have a high prevalence of NAFLD and severe metabolic disorders. The prevalence of NASH seems to be considerably higher in obese and postmenopausal women with NAFLD. Key Words: Nonalcoholic fatty liver disease Y Risk factors Y Steatohepatitis Y Obesity Y Postmenopausal women.
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onalcoholic fatty liver disease (NAFLD) affects approximately 15% to 30% of the general population in various countries; its prevalence is increasing globally, along with an increase in overweight and obese populations.1
Prevalence of nonalcoholic fatty liver disease and its metabolic risk factors in women of different ages and body mass index Zhongli Wang, MD, PhD,1 Ming Xu, MD,1 Zhengguo Hu, MD,1 and Umid Kumar Shrestha, MD, PhD2 Abstract Objective: This study aims to investigate the prevalence of nonalcoholic fatty liver disease (NAFLD), to determine the metabolic risk factors of this disease, and to predict nonalcoholic steatohepatitis (NASH) with liver fibrosis in women of different ages and body mass index (BMI). Methods: In 2010-2011, a cross-sectional survey was conducted among 9,360 women at the health checkup center of Zhongnan Hospital (Wuhan, China). The probability of NASH with liver fibrosis was predicted using BAAT (BMI, age, alanine aminotransferase, and triglycerides) score. Results: The prevalence of NAFLD increased from 5.3% to 18.8% in women younger than 45 years versus women aged 45 to 55 years and rose to 27.8% in women older than 55 years. In obese women, the prevalence of NAFLD was 48.4%. Women older than 45 years and obese women with NAFLD had more unfavorable metabolic risk factors. Multiple regression analyses showed that increased BMI and low aspartate aminotransferaseYtoYalanine aminotransferase ratio were closely related to NAFLD in women of different ages, whereas increasing BMI, BAAT score, age, high triglycerides, alanine aminotransferase, and low aspartate aminotransferaseYtoYalanine aminotransferase ratio were all closely related to NAFLD in obese women. The prevalence of NASH with a BAAT index of 3 or higher was 13.2% and 14.9% in women older than 55 years and obese women with NAFLD, respectively. Conclusions: Obese and postmenopausal women have a high prevalence of NAFLD and severe metabolic disorders. The prevalence of NASH seems to be considerably higher in obese and postmenopausal women with NAFLD. Key Words: Nonalcoholic fatty liver disease Y Risk factors Y Steatohepatitis Y Obesity Y Postmenopausal women.
N
onalcoholic fatty liver disease (NAFLD) affects approximately 15% to 30% of the general population in various countries; its prevalence is increasing globally, along with an increase in overweight and obese populations.1
