HHS Public Access Author manuscript Author Manuscript
Clin Gastroenterol Hepatol. Author manuscript; available in PMC 2016 November 01. Published in final edited form as: Clin Gastroenterol Hepatol. 2015 November ; 13(11): 1907–1918. doi:10.1016/j.cgh.2015.07.050.
The Prevalence of Barrett’s Esophagus in Asian Countries: A Systematic Review and Meta-analysis Seiji Shiota1,2, Siddharth Singh3, Ashraf Anshasi2, and Hashem B. El-Serag1,2 1Section
of Gastroenterology and Hepatology, Department of Medicine, Michael E. DeBakey VA Medical Center, Houston, Texas, USA
Author Manuscript
2Sections
of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
3Division
of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota
Abstract Background & Aims—The prevalence and risk factors of Barrett’s esophagus (BE) in Asian countries are unclear. Studies report a wide range of BE prevalence in Asian countries. We conducted a systematic review and meta-analysis to examine the prevalence of BE, its temporal changes and risk factors in Asian countries.
Author Manuscript
Methods—Two investigators performed independent literature searches using PubMed and EMBASE databases, and subsequent data abstraction for studies had to meet several set inclusion and exclusion criteria. Pooled BE prevalence was calculated using a random-effect model. Estimates of relative risk for possible risk or protective factors were also calculated. Results—A total of 51 studies (N = 453,147), mainly from Eastern Asia, were included. The pooled prevalence of endoscopic BE was 7.8% (95% CI = 5.0 – 12.1; 23 studies) and of histologically confirmed BE was 1.3% (95% CI = 0.7 – 2.2; 28 studies). Most (82.1%) of histologic BE was short-segment BE (
Clin Gastroenterol Hepatol. Author manuscript; available in PMC 2016 November 01. Published in final edited form as: Clin Gastroenterol Hepatol. 2015 November ; 13(11): 1907–1918. doi:10.1016/j.cgh.2015.07.050.
The Prevalence of Barrett’s Esophagus in Asian Countries: A Systematic Review and Meta-analysis Seiji Shiota1,2, Siddharth Singh3, Ashraf Anshasi2, and Hashem B. El-Serag1,2 1Section
of Gastroenterology and Hepatology, Department of Medicine, Michael E. DeBakey VA Medical Center, Houston, Texas, USA
Author Manuscript
2Sections
of Gastroenterology and Hepatology, Department of Medicine, Baylor College of Medicine, Houston, Texas, USA
3Division
of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota
Abstract Background & Aims—The prevalence and risk factors of Barrett’s esophagus (BE) in Asian countries are unclear. Studies report a wide range of BE prevalence in Asian countries. We conducted a systematic review and meta-analysis to examine the prevalence of BE, its temporal changes and risk factors in Asian countries.
Author Manuscript
Methods—Two investigators performed independent literature searches using PubMed and EMBASE databases, and subsequent data abstraction for studies had to meet several set inclusion and exclusion criteria. Pooled BE prevalence was calculated using a random-effect model. Estimates of relative risk for possible risk or protective factors were also calculated. Results—A total of 51 studies (N = 453,147), mainly from Eastern Asia, were included. The pooled prevalence of endoscopic BE was 7.8% (95% CI = 5.0 – 12.1; 23 studies) and of histologically confirmed BE was 1.3% (95% CI = 0.7 – 2.2; 28 studies). Most (82.1%) of histologic BE was short-segment BE (
