Prevalence, Clinical Correlates, and Functional Impact of Subaortic Ventricular Septal Bulge (from the Baltimore Longitudinal Study of Aging) Marco Canepa, MDa,b,c,d, Omar Malti, MDa,b, Melissa David, RDCSa,b,e, Majd AlGhatrif, MDa,b,c, James B. Strait, MD, PhDb, Pietro Ameri, MD, PhDd, Claudio Brunelli, MDd, Edward G. Lakatta, MDb, Luigi Ferrucci, MD, PhDa, and Theodore P. Abraham, MDc,* A localized hypertrophy of the subaortic segment of the ventricular septum—ventricular septal bulge (VSB)—has been frequently described in series of elderly population, but its prevalence with age, clinical correlates, and impact on cardiac function and exercise capacity remain uncertain. We explored these associations in a cross-sectional sample without known cardiac disease from the Baltimore Longitudinal Study of Aging. We randomly selected 700 participants (50% men, mean age 64 – 15, range 26 to 95 years) and reviewed their echocardiograms. We identified 28 men and 21 women with VSB (7% overall prevalence). The prevalence of VSB significantly increased with age in both genders (p 50% greater than the thickness of the septum at its mid-distal point (at the second third of the septum). In the example, a male participant who met the criteria for a diagnosis of septal bulge (i.e., proximal focal hypertrophy with a thickness of 18 mm and 63% greater than the thickness of the midseptum).

enrolled in the study if they are healthy at baseline and undergo 3 days of medical examinations approximately every 2 years.13 Seven hundred BLSA participants without a history of coronary artery disease and/or heart failure and without valvular disease greater than mild in severity and/or LV systolic dysfunction (defined as LV ejection fraction

Prevalence, clinical correlates, and functional impact of subaortic ventricular septal bulge (from the Baltimore Longitudinal Study of Aging).

A localized hypertrophy of the subaortic segment of the ventricular septum-ventricular septal bulge (VSB)-has been frequently described in series of e...
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