Clinical Infectious Diseases Advance Access published February 11, 2015 1

Prevalence and incidence of respiratory syncytial virus and other respiratory viral infections in children 6 months to 10 years of

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age with influenza-like illness enrolled in a randomized trial

Terry Nolan1,§, Charissa Borja-Tabora2, Pio Lopez3, Lily Weckx4, Rolando Ulloa-

Gutierrez5, Eduardo Lazcano-Ponce6, Angkool Kerdpanich7, Miguel Angel Rodriguez Weber8, Abiel Mascareñas de Los Santos9, Juan-Carlos Tinoco10, Marco Aurelio P.

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Aurelio Cruz-Valdez6, Yang Feng13, Ping Li14, Serge Durviaux13, Gerco Haars13, Sumita

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Roy-Ghanta14, David W. Vaughn15, Sylvia Taylor13,§

1

Murdoch Children’s Research Institute and Melbourne School of Population and Global

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Health, University of Melbourne, Carlton, Victoria, Australia 2

Research Institute for Tropical Medicine, Department of Health, Alabang, Muntinlupa City,

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Philippines Centro de Estudios en Infectologia Pediatrica, Cali, Colombia

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Pediatric Infectious Diseases, Department of Pediatrics, Universidade Federal de São

Paulo, São Paulo, Brazil 5

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Instituto Costarricense de Investigaciones Clínicas, San José, Costa Rica

6

Ac

National Institute of Public Health of Mexico, Cuernavaca Morelos, Mexico

7

Infectious Diseases Unit, Department of Pediatrics, Phramongkutklao Hospital, Thailand

© The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons AttributionNonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact [email protected].

Downloaded from http://cid.oxfordjournals.org/ at University of Michigan on June 12, 2015

Safadi11, Lim Fong Seng12, Marcela Hernandez-de Mezerville13, Idis Faingezicht5,

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Instituto Nacional de Pediatría de Mexico, Mexico

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Servicios Medicos Universidad Autonoma de Nuevo Leon, Monterray, Mexico

10

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Hospital General de Durango, Durango, Mexico

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Department of Pediatrics, Faculdade de Ciências Médicas da Santa Casa de São Paulo

and Associação Fundo de Incentivo à Pesquisa, São Paulo, Brazil 12

GlaxoSmithKline Vaccines, Wavre, Belgium

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GlaxoSmithKline Vaccines, King of Prussia, PA, USA

GlaxoSmithKline Vaccines, Rixensart, Belgium; Sylvia Taylor, GlaxoSmithKline Vaccines,

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Wavre, Belgium

Corresponding author: Terry Nolan, Murdoch Children’s Research Institute and Melbourne

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School of Population and Global Health, University of Melbourne, Carlton, Victoria 3010, Australia. Tel: +61 3 8344 9350; Fax: +61 3 9347 6929; E-mail: [email protected]. Alternative corresponding author: Sylvia Taylor, GlaxoSmithKline Vaccines, 20 Avenue Fleming, B-1330 Wavre, Belgium. Tel: +32 4721 92915; Email: [email protected]. §

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Authors Nolan and Taylor contributed equally to this manuscript.

Key point summary: The epidemiology of RSV in children aged 6 months to

Prevalence and Incidence of Respiratory Syncytial Virus and Other Respiratory Viral Infections in Children Aged 6 Months to 10 Years With Influenza-like Illness Enrolled in a Randomized Trial.

The high burden of respiratory syncytial virus (RSV)-associated morbidity and mortality makes vaccine development a priority...
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