Interactive CardioVascular and Thoracic Surgery Advance Access published December 23, 2014

Cite this article as: Minasian SM, Galagudza MM, Dmitriev YV, Karpov AA, Vlasov TD. Preservation of the donor heart: from basic science to clinical studies. Interact CardioVasc Thorac Surg 2014; doi:10.1093/icvts/ivu432.

Preservation of the donor heart: from basic science to clinical studies Sarkis M. Minasiana,b, Michael M. Galagudzaa,b,*, Yuri V. Dmitrieva, Andrey A. Karpova,b and Timur D. Vlasova,b a b

Institute of Experimental Medicine, Federal Almazov Medical Research Centre, St Petersburg, Russian Federation Department of Pathophysiology, First Pavlov State Medical University of St Petersburg, St Petersburg, Russian Federation

* Corresponding author. Institute of Experimental Medicine, Federal Almazov Medical Research Centre, Akkuratova Str. 2, 197341, St Petersburg, Russian Federation. Tel: +7-812-4997035; fax: +7-812-4997069; e-mail: [email protected] (M.M. Galagudza). Received 3 September 2014; received in revised form 7 November 2014; accepted 3 December 2014

Abstract The methods of donor heart preservation are aimed at minimizing graft dysfunction caused by ischaemia–reperfusion injury (IRI) which inevitably occurs during the ex vivo transport interval. At present, the standard technique of heart preservation is cardiac arrest followed by static cold storage in a crystalloid heart preservation solution (HPS). This technique ensures an acceptable level of heart protection against IRI for

Preservation of the donor heart: from basic science to clinical studies.

The methods of donor heart preservation are aimed at minimizing graft dysfunction caused by ischaemia-reperfusion injury (IRI) which inevitably occurs...
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