Prenatal Diagnosis of Transposition of the Great Arteries over a 20-Year Period: Improved but Imperfect
Maria C Escobar-Diaz, MD*‡, Lindsay R Freud, MD*‡, Alejandra Bueno, MD*‡, David W Brown, MD*‡, Kevin Friedman, MD*‡, David Schidlow, MD*‡, Sitaram Emani, MD†§, Pedro del Nido, MD†§, Wayne Tworetzky, MD*‡. Departments of Cardiology * and Cardiac Surgery†, Boston Children’s Hospital, Boston, Massachusetts, USA Departments of Pediatrics ‡ and Surgery §, Harvard Medical School, Boston, Massachusetts, USA
Address correspondence to: Maria C Escobar-Diaz, Department of Cardiology, Boston Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115. [email protected] Tel: 617-355-8366; fax: 617-7349930
Key words: Prenatal diagnosis, transposition of the great arteries, outflow tract view, survival, metabolic acidosis.
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/uog.14751
This article is protected by copyright. All rights reserved
ABSTRACT Objective: To evaluate temporal trends in prenatal diagnosis of transposition of the great arteries with intact ventricular septum (TGA/IVS) and its impact on neonatal morbidity and mortality. Methods: Newborns with TGA/IVS referred for surgical management to our center over a 20-year period (1992 – 2011) were included. The study time was divided into 5 four-year periods, and the primary outcome was rate of prenatal diagnosis. Secondary outcomes included neonatal pre-operative status and perioperative survival. Results: Of the 340 patients, 81 (24%) had a prenatal diagnosis. Prenatal diagnosis increased over the study period from 6% to 41% (p
Maria C Escobar-Diaz, MD*‡, Lindsay R Freud, MD*‡, Alejandra Bueno, MD*‡, David W Brown, MD*‡, Kevin Friedman, MD*‡, David Schidlow, MD*‡, Sitaram Emani, MD†§, Pedro del Nido, MD†§, Wayne Tworetzky, MD*‡. Departments of Cardiology * and Cardiac Surgery†, Boston Children’s Hospital, Boston, Massachusetts, USA Departments of Pediatrics ‡ and Surgery §, Harvard Medical School, Boston, Massachusetts, USA
Address correspondence to: Maria C Escobar-Diaz, Department of Cardiology, Boston Children’s Hospital, 300 Longwood Avenue, Boston, MA 02115. [email protected] Tel: 617-355-8366; fax: 617-7349930
Key words: Prenatal diagnosis, transposition of the great arteries, outflow tract view, survival, metabolic acidosis.
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/uog.14751
This article is protected by copyright. All rights reserved
ABSTRACT Objective: To evaluate temporal trends in prenatal diagnosis of transposition of the great arteries with intact ventricular septum (TGA/IVS) and its impact on neonatal morbidity and mortality. Methods: Newborns with TGA/IVS referred for surgical management to our center over a 20-year period (1992 – 2011) were included. The study time was divided into 5 four-year periods, and the primary outcome was rate of prenatal diagnosis. Secondary outcomes included neonatal pre-operative status and perioperative survival. Results: Of the 340 patients, 81 (24%) had a prenatal diagnosis. Prenatal diagnosis increased over the study period from 6% to 41% (p
