976

LETTERS TO THE EDITOR

virus-specific immunoglobulin M, J. Pediatr., been described in numerous viscera and in 111,592-595. the brain (Alkalay et a/., 1987). In cases of chickenpox during pregnancy, Gray, F., Mohr, M., Rozenberg, F., Belec, F., Lescs, M.C., Dournon, E., Saint-Clair, E., the following clinical management can be Scaravili, F. (1992). Varicella zoster virus proposed: encephalitis in acquired immunodeficiency syn(a) Maternal contact with the virus and drome: report of 4 cases, Neuropafhol. Appl. absence of immunity: early injection of Neurobiol. (in press). specific gamma-globulin (0.3 ml/kg), Grose, C., Itani, 0. (1989). Pathogenesis of congenital infection with three diverse viruses: possibly repeated. varicella-zoster virus, human parvovirus, and (b) In pregnancies complicated by chickenhuman immunodeficiencyvirus, Semin. Perinat., pox between 8 and 20 weeks’ gestational 13,278-293. age, repeated sonography should be performed to detect VZV congenital syndrome, but some defects cannot be diagnosed (chorioretinitis, cataract, parPrenatal diagnosis of Roberts syndrome alysis). Amniocentesis and fetal blood sampling should be performed to isolate We enjoyed reading the excellent article by the virus or to detect specific IgM or Stioui et al. (1992) regarding first-trimester indirect signs such as elevated interferon prenatal diagnosis of Roberts syndrome. and haematological or hepatological In their conclusion, the authors postulate disorders. that at a later time in pregnancy than in their (c) Acyclovir is not recommended during studies, the skeletal abnormalities can probpregnancy as its safety has not been ably be detected. In fact, in 1977, we reported clearly established. a prenatal diagnosis of Roberts syndrome in JEAN-CLAUDE PONS, FLOREROZENBERG, a family at risk by detection of skeletal and MARIE-CLAIRE IMBERT, PIERRE LEBON, renal abnormalities. FRANGOIS OLIVENNES, CHRISTOPHE K. HIRSCHHORN A N D S . KAFFE LELAIDIER, NADIASTRUB,M I C ~ LVIAL E Department of Pediatrics, AND RENEFRYDMAN The Mount Sinai Medical Center, H6pital Antoine BPclere, 92141 Clarnart, 1 Gustave L. Levy Place, France and H6pital Saint- Vincent-de-Paul, New York. N Y 10029-6574, Paris, France U.S.A.

REFERENCES Alkalay, A.L., Pomerance, J.J., Rimoin, D.L. (1987). Fetal varicella syndrome, J . Pediafr., 111,320-323.

Brunell, P.A., Kotchmar, G.S. (1981). Zoster in infancy: failure to maintain virus latency following intra-uterine infection, J . Pediafr.,98,71. Cuthbertson, G . , Weiner, C.P., Giller, R.H., Grose, C. (1987). Prenatal diagnosis of secondtrimester congenital varicella syndrome by

REFERENCES Kaffe, S., Rose, J.S., Godmilow, L., Walker, B.A., Kerenyi, T., Beratis, N., Reyes, P., Hirschhorn, K. (1977). Prenatal diagnosis ofrenal anomalies, Am. J . Med. Genet.,6,447-451. Stioui, S . , Privitera, O.,Brambati, B., Zuliani, G . , Lalatta, F., Simoni, G. (1992). First-trimester prenatal diagnosis of Roberts syndrome, Prenat. Diugn., 12, 145-149.

Prenatal diagnosis of Roberts syndrome.

976 LETTERS TO THE EDITOR virus-specific immunoglobulin M, J. Pediatr., been described in numerous viscera and in 111,592-595. the brain (Alkalay et...
69KB Sizes 0 Downloads 0 Views