Accepted Manuscript Title: Premotor symptoms and the risk of Parkinson’s disease: a case-control study in Mexican population. Authors: Mayela Rodr´ıguez-Violante, Adib Jorge de Sar´achaga, Amin Cervantes-Arriaga, Ned Merari Davila-Avila, Edith Carre´on-Bautista, Ingrid Estrada-Bellmann, Guillermo Parra-L´opez, Diego Cruz-Fino, Francisco Pascasio-Astudillo PII: DOI: Reference:
S0303-8467(17)30177-4 http://dx.doi.org/doi:10.1016/j.clineuro.2017.06.010 CLINEU 4723
To appear in:
Clinical Neurology and Neurosurgery
Received date: Revised date: Accepted date:
17-3-2017 9-6-2017 13-6-2017
Please cite this article as: Rodr´ıguez-Violante Mayela, de Sar´achaga Adib Jorge, Cervantes-Arriaga Amin, Davila-Avila Ned Merari, Carre´on-Bautista Edith, Estrada-Bellmann Ingrid, Parra-L´opez Guillermo, Cruz-Fino Diego, PascasioAstudillo Francisco.Premotor symptoms and the risk of Parkinson’s disease: a case-control study in Mexican population.Clinical Neurology and Neurosurgery http://dx.doi.org/10.1016/j.clineuro.2017.06.010 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Premotor symptoms and the risk of Parkinson’s disease: a case-control study in Mexican population.
Running title: Premotor risk for PD
Mayela Rodríguez-Violante a,b, Adib Jorge de Saráchaga a, Amin Cervantes-Arriaga a, Ned Merari Davila-Avila a, Edith Carreón-Bautista a, Ingrid Estrada-Bellmann c, Guillermo ParraLópez a,b, Diego Cruz-Fino a,b, Francisco Pascasio-Astudillo a,b
a
Clinical Neurodegenerative Research Unit, National Institute of Neurology and
Neurosurgery, Mexico City, Mexico. b
Movement Disorder Clinic, National Institute of Neurology and Neurosurgery, Mexico City,
Mexico. c
Movement Disorder Clinic, Hospital Universitario, Monterrey, Nuevo León, México.
Correspondence: Mayela Rodríguez Violante. Movement Disorders Clinic, National Institute of Neurology and Neurosurgery. Insurgentes Sur #3877 Col. La Fama 14269 Mexico City, Mexico. [email protected]
Highlights
Subjects with PD and healthy subjects were included.
Premotor symptoms prevalence was 77.7% in the PD group vs 41.3% in controls.
The presence of non-motor symptoms yield a prediction success of 71.2%.
Abstract Objectives. To assess the prevalence of pre-motor symptoms and estimate the risk for developing Parkinson’s disease in Mexican population. Patients and Methods. A case-control study was carried out with consecutive subjects with Parkinson’s disease from two different referral centers in Mexico. Gender- and age-matched controls were randomly selected from the participating hospitals. All subjects were assessed using
a structured questionnaire for the assessment of pre-motor symptoms (hyposmia, depression, anxiety, constipation, and sleep disorders). Odds ratios (OR) were calculated using logistic regression analysis. Results. A total of 430 subjects with PD and 430 healthy subjects were included. Premotor symptoms prevalence was 77.7% (n=334) for the PD group, compared to 41.3% (n=178) in the control group (p
S0303-8467(17)30177-4 http://dx.doi.org/doi:10.1016/j.clineuro.2017.06.010 CLINEU 4723
To appear in:
Clinical Neurology and Neurosurgery
Received date: Revised date: Accepted date:
17-3-2017 9-6-2017 13-6-2017
Please cite this article as: Rodr´ıguez-Violante Mayela, de Sar´achaga Adib Jorge, Cervantes-Arriaga Amin, Davila-Avila Ned Merari, Carre´on-Bautista Edith, Estrada-Bellmann Ingrid, Parra-L´opez Guillermo, Cruz-Fino Diego, PascasioAstudillo Francisco.Premotor symptoms and the risk of Parkinson’s disease: a case-control study in Mexican population.Clinical Neurology and Neurosurgery http://dx.doi.org/10.1016/j.clineuro.2017.06.010 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.
Premotor symptoms and the risk of Parkinson’s disease: a case-control study in Mexican population.
Running title: Premotor risk for PD
Mayela Rodríguez-Violante a,b, Adib Jorge de Saráchaga a, Amin Cervantes-Arriaga a, Ned Merari Davila-Avila a, Edith Carreón-Bautista a, Ingrid Estrada-Bellmann c, Guillermo ParraLópez a,b, Diego Cruz-Fino a,b, Francisco Pascasio-Astudillo a,b
a
Clinical Neurodegenerative Research Unit, National Institute of Neurology and
Neurosurgery, Mexico City, Mexico. b
Movement Disorder Clinic, National Institute of Neurology and Neurosurgery, Mexico City,
Mexico. c
Movement Disorder Clinic, Hospital Universitario, Monterrey, Nuevo León, México.
Correspondence: Mayela Rodríguez Violante. Movement Disorders Clinic, National Institute of Neurology and Neurosurgery. Insurgentes Sur #3877 Col. La Fama 14269 Mexico City, Mexico. [email protected]
Highlights
Subjects with PD and healthy subjects were included.
Premotor symptoms prevalence was 77.7% in the PD group vs 41.3% in controls.
The presence of non-motor symptoms yield a prediction success of 71.2%.
Abstract Objectives. To assess the prevalence of pre-motor symptoms and estimate the risk for developing Parkinson’s disease in Mexican population. Patients and Methods. A case-control study was carried out with consecutive subjects with Parkinson’s disease from two different referral centers in Mexico. Gender- and age-matched controls were randomly selected from the participating hospitals. All subjects were assessed using
a structured questionnaire for the assessment of pre-motor symptoms (hyposmia, depression, anxiety, constipation, and sleep disorders). Odds ratios (OR) were calculated using logistic regression analysis. Results. A total of 430 subjects with PD and 430 healthy subjects were included. Premotor symptoms prevalence was 77.7% (n=334) for the PD group, compared to 41.3% (n=178) in the control group (p
