This article was downloaded by: [Wayne State University] On: 26 November 2014, At: 02:43 Publisher: Taylor & Francis Informa Ltd Registered in England and Wales Registered Number: 1072954 Registered office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH, UK
Computer Methods in Biomechanics and Biomedical Engineering Publication details, including instructions for authors and subscription information: http://www.tandfonline.com/loi/gcmb20
Special issue on computational cellular and biomolecular mechanics and mechanobiology a
Amit Gefen (Guest editor) & Cees Oomens (Guest editor) a
b
Department of Biomedical Engineering, Tel Aviv University, Ramat Aviv, Israel
b
Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands Published online: 21 Oct 2013.
To cite this article: Amit Gefen (Guest editor) & Cees Oomens (Guest editor) (2013) Special issue on computational cellular and biomolecular mechanics and mechanobiology, Computer Methods in Biomechanics and Biomedical Engineering, 16:10, 1041-1041, DOI: 10.1080/10255842.2013.851520 To link to this article: http://dx.doi.org/10.1080/10255842.2013.851520
PLEASE SCROLL DOWN FOR ARTICLE Taylor & Francis makes every effort to ensure the accuracy of all the information (the “Content”) contained in the publications on our platform. However, Taylor & Francis, our agents, and our licensors make no representations or warranties whatsoever as to the accuracy, completeness, or suitability for any purpose of the Content. Any opinions and views expressed in this publication are the opinions and views of the authors, and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content should not be relied upon and should be independently verified with primary sources of information. Taylor and Francis shall not be liable for any losses, actions, claims, proceedings, demands, costs, expenses, damages, and other liabilities whatsoever or howsoever caused arising directly or indirectly in connection with, in relation to or arising out of the use of the Content. This article may be used for research, teaching, and private study purposes. Any substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing, systematic supply, or distribution in any form to anyone is expressly forbidden. Terms & Conditions of access and use can be found at http:// www.tandfonline.com/page/terms-and-conditions
Computer Methods in Biomechanics and Biomedical Engineering, 2013 Vol. 16, No. 10, 1041, http://dx.doi.org/10.1080/10255842.2013.851520
PREFACE
Downloaded by [Wayne State University] at 02:43 26 November 2014
Special issue on computational cellular and biomolecular mechanics and mechanobiology
Cells are subjected to mechanical loads as a result of physiological function of the body, including weightbearing, gravity, inertia or cavity pressures. The magnitudes and time profiles of these loads are determined by many extrinsic and intrinsic factors that are characteristic to the individual, including age, diseases and lifestyle. Mechanical loads around and within cells and cell organelles can substantially influence cellular function. Furthermore, exposure to mechanical loading within physiological thresholds is, in many cases, crucial for normal cell function and tissue maintenance. On the other hand, excessive loading or chronic sub-normal loading may cause cell damage or cell death, and thereby, lead to tissue degradation. For example, critically elevated loads may damage cells instantaneously as in an acute injury (trauma), or over time as in formation of chronic wounds. Cells are also dynamic living structures that change shape, move or migrate – by producing the adequate mechanical forces and by physically and chemically interacting with their surroundings. The intracellular architecture and the mechanical properties of cells and their organelles are important factors affecting these processes, and so are the physical, chemical, electrical and mechanical characteristics of the extracellular environment. Recently, new computational biomechanical and bioengineering methods have been developed to obtain data on cellular forces, mechanical properties and mechanical function of cells and organelles. Such information should ultimately provide better understanding of how cells actually function and how they biomechanically react to and interact with their
q 2013 Taylor & Francis
environment. The role of computational biomechanics in this arena is crucial to spawn hypotheses and to design and interpret the complex experimental measurements at the microscale. This special issue of Computer Methods in Biomechanics and Biomedical Engineering (CMBBE) hence focuses on new and stimulating developments in the field of computational cellular and biomolecular mechanics. Specific topics that are in the focus of the present issue are modelling cell adhesion and tissue deposition; cell motility and migration; fertilisation; cellular damage and injury; cell –cell and cell – extracellular matrix communications and mechanotransduction, particularly for tissue engineering applications. Contributions were made by leading groups in the field, from Europe, the USA and Asia, based on the Special Session held under the same title and organised by A.G. at the Berlin CMBBE 2012 Annual Conference. Together, the present collection of papers demonstrates the growing international interest in this new exciting field of computational cell and sub-cellular biomechanics. Amit Gefen (Guest editor) Department of Biomedical Engineering, Tel Aviv University, Ramat Aviv, Israel Email: [email protected] Cees Oomens (Guest editor) Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands Email: [email protected]
Computer Methods in Biomechanics and Biomedical Engineering Publication details, including instructions for authors and subscription information: http://www.tandfonline.com/loi/gcmb20
Special issue on computational cellular and biomolecular mechanics and mechanobiology a
Amit Gefen (Guest editor) & Cees Oomens (Guest editor) a
b
Department of Biomedical Engineering, Tel Aviv University, Ramat Aviv, Israel
b
Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands Published online: 21 Oct 2013.
To cite this article: Amit Gefen (Guest editor) & Cees Oomens (Guest editor) (2013) Special issue on computational cellular and biomolecular mechanics and mechanobiology, Computer Methods in Biomechanics and Biomedical Engineering, 16:10, 1041-1041, DOI: 10.1080/10255842.2013.851520 To link to this article: http://dx.doi.org/10.1080/10255842.2013.851520
PLEASE SCROLL DOWN FOR ARTICLE Taylor & Francis makes every effort to ensure the accuracy of all the information (the “Content”) contained in the publications on our platform. However, Taylor & Francis, our agents, and our licensors make no representations or warranties whatsoever as to the accuracy, completeness, or suitability for any purpose of the Content. Any opinions and views expressed in this publication are the opinions and views of the authors, and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content should not be relied upon and should be independently verified with primary sources of information. Taylor and Francis shall not be liable for any losses, actions, claims, proceedings, demands, costs, expenses, damages, and other liabilities whatsoever or howsoever caused arising directly or indirectly in connection with, in relation to or arising out of the use of the Content. This article may be used for research, teaching, and private study purposes. Any substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing, systematic supply, or distribution in any form to anyone is expressly forbidden. Terms & Conditions of access and use can be found at http:// www.tandfonline.com/page/terms-and-conditions
Computer Methods in Biomechanics and Biomedical Engineering, 2013 Vol. 16, No. 10, 1041, http://dx.doi.org/10.1080/10255842.2013.851520
PREFACE
Downloaded by [Wayne State University] at 02:43 26 November 2014
Special issue on computational cellular and biomolecular mechanics and mechanobiology
Cells are subjected to mechanical loads as a result of physiological function of the body, including weightbearing, gravity, inertia or cavity pressures. The magnitudes and time profiles of these loads are determined by many extrinsic and intrinsic factors that are characteristic to the individual, including age, diseases and lifestyle. Mechanical loads around and within cells and cell organelles can substantially influence cellular function. Furthermore, exposure to mechanical loading within physiological thresholds is, in many cases, crucial for normal cell function and tissue maintenance. On the other hand, excessive loading or chronic sub-normal loading may cause cell damage or cell death, and thereby, lead to tissue degradation. For example, critically elevated loads may damage cells instantaneously as in an acute injury (trauma), or over time as in formation of chronic wounds. Cells are also dynamic living structures that change shape, move or migrate – by producing the adequate mechanical forces and by physically and chemically interacting with their surroundings. The intracellular architecture and the mechanical properties of cells and their organelles are important factors affecting these processes, and so are the physical, chemical, electrical and mechanical characteristics of the extracellular environment. Recently, new computational biomechanical and bioengineering methods have been developed to obtain data on cellular forces, mechanical properties and mechanical function of cells and organelles. Such information should ultimately provide better understanding of how cells actually function and how they biomechanically react to and interact with their
q 2013 Taylor & Francis
environment. The role of computational biomechanics in this arena is crucial to spawn hypotheses and to design and interpret the complex experimental measurements at the microscale. This special issue of Computer Methods in Biomechanics and Biomedical Engineering (CMBBE) hence focuses on new and stimulating developments in the field of computational cellular and biomolecular mechanics. Specific topics that are in the focus of the present issue are modelling cell adhesion and tissue deposition; cell motility and migration; fertilisation; cellular damage and injury; cell –cell and cell – extracellular matrix communications and mechanotransduction, particularly for tissue engineering applications. Contributions were made by leading groups in the field, from Europe, the USA and Asia, based on the Special Session held under the same title and organised by A.G. at the Berlin CMBBE 2012 Annual Conference. Together, the present collection of papers demonstrates the growing international interest in this new exciting field of computational cell and sub-cellular biomechanics. Amit Gefen (Guest editor) Department of Biomedical Engineering, Tel Aviv University, Ramat Aviv, Israel Email: [email protected] Cees Oomens (Guest editor) Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, the Netherlands Email: [email protected]
