Expert Review of Anti-infective Therapy Downloaded from informahealthcare.com by National Taiwan University on 01/15/15 For personal use only.
Review
Predictors of severity for postnatal cytomegalovirus infection in preterm infants and implications for treatment Expert Rev. Anti Infect. Ther. 12(11), 1345–1355 (2014)
Julia Gunkel1, Tom FW Wolfs2, Linda S de Vries1 and Joppe Nijman*1 1 Department of Neonatology, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, The Netherlands 2 Department of Pediatric Infectious Diseases, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, The Netherlands *Author for correspondence: Tel.: +31 887 554 545 Fax: +31 887 555 320 [email protected]
informahealthcare.com
Postnatal cytomegalovirus (CMV) infection is common in neonates and is mostly acquired through infected breast milk from seropositive mothers. In this review, risk factors of postnatal CMV transmission and predictors of severity, preventive measures and treatment of symptomatic postnatal CMV infection in preterm infants are discussed. Several viral, transmission route and host factors have been associated with a higher risk of postnatal CMV transmission from mother to child. Severity predictors of symptomatic postnatal CMV infection may include extreme prematurity (gestational age
Review
Predictors of severity for postnatal cytomegalovirus infection in preterm infants and implications for treatment Expert Rev. Anti Infect. Ther. 12(11), 1345–1355 (2014)
Julia Gunkel1, Tom FW Wolfs2, Linda S de Vries1 and Joppe Nijman*1 1 Department of Neonatology, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, The Netherlands 2 Department of Pediatric Infectious Diseases, University Medical Center Utrecht, P.O. Box 85500, 3508 GA Utrecht, The Netherlands *Author for correspondence: Tel.: +31 887 554 545 Fax: +31 887 555 320 [email protected]
informahealthcare.com
Postnatal cytomegalovirus (CMV) infection is common in neonates and is mostly acquired through infected breast milk from seropositive mothers. In this review, risk factors of postnatal CMV transmission and predictors of severity, preventive measures and treatment of symptomatic postnatal CMV infection in preterm infants are discussed. Several viral, transmission route and host factors have been associated with a higher risk of postnatal CMV transmission from mother to child. Severity predictors of symptomatic postnatal CMV infection may include extreme prematurity (gestational age
