Holder et al. International Journal of Emergency Medicine (2016) 9:10 DOI 10.1186/s12245-016-0106-7
ORIGINAL RESEARCH
Open Access
Predictors of early progression to severe sepsis or shock among emergency department patients with nonsevere sepsis Andre L. Holder1,8*, Namita Gupta2, Elizabeth Lulaj3, Miriam Furgiuele4, Idaly Hidalgo5, Michael P. Jones6, Tiphany Jolly7, Paul Gennis4 and Adrienne Birnbaum4
Abstract Background: Progression from nonsevere sepsis—i.e., sepsis without organ failure or shock—to severe sepsis or shock among emergency department (ED) patients has been associated with significant mortality. Early recognition in the ED of those who progress to severe sepsis or shock during their hospital course may improve patient outcomes. We sought to identify clinical, demographic, and laboratory parameters that predict progression to severe sepsis, septic shock, or death within 96 h of ED triage among patients with initial presentation of nonsevere sepsis. Methods: This is a retrospective cohort of patients presenting to a single urban academic ED from November 2008 to October 2010. Patients aged 18 years or older who met criteria for sepsis and had a lactate level measured in the ED were included. Patients were excluded if they had any combination of the following: a systolic blood pressure
ORIGINAL RESEARCH
Open Access
Predictors of early progression to severe sepsis or shock among emergency department patients with nonsevere sepsis Andre L. Holder1,8*, Namita Gupta2, Elizabeth Lulaj3, Miriam Furgiuele4, Idaly Hidalgo5, Michael P. Jones6, Tiphany Jolly7, Paul Gennis4 and Adrienne Birnbaum4
Abstract Background: Progression from nonsevere sepsis—i.e., sepsis without organ failure or shock—to severe sepsis or shock among emergency department (ED) patients has been associated with significant mortality. Early recognition in the ED of those who progress to severe sepsis or shock during their hospital course may improve patient outcomes. We sought to identify clinical, demographic, and laboratory parameters that predict progression to severe sepsis, septic shock, or death within 96 h of ED triage among patients with initial presentation of nonsevere sepsis. Methods: This is a retrospective cohort of patients presenting to a single urban academic ED from November 2008 to October 2010. Patients aged 18 years or older who met criteria for sepsis and had a lactate level measured in the ED were included. Patients were excluded if they had any combination of the following: a systolic blood pressure
