Predictive value of serum transthyretin for outcome in acute ischemic stroke Wojciech Ambrosius1☯*, Slawomir Michalak2☯, Radosław Kazmierski3‡, Natalia Andrzejewska3, Wojciech Kozubski1‡ 1 Department of Neurology, Poznan University of Medical Sciences, Poznan, Poland, 2 Department of Neurochemistry and Neuropathology, Poznan University of Medical Sciences, Poznan, Poland, 3 Department of Neurology and Cerebrovascular Disorders, Ludwik Bierkowski Hospital, Poznan University of Medical Sciences, Poznan, Poland ☯ These authors contributed equally to this work. ‡ These authors also contributed equally to this work. * [email protected]
Abstract Introduction The impact of choroid plexus with its blood–cerebrospinal fluid barrier in the ischemic stroke pathology is poorly explored. Transthyretin (TTR) is a protein synthesized in liver and just in choroid plexus.
Objectives The current study was designed to assess the prognostic value of serum TTR for functional outcome (at the time of hospital discharge) and long-term (one-year) overall mortality in ischemic stroke patients.
Patients and methods We conducted a prospective observational study. Patients (n = 81) with acute (< 24 hours of symptoms onset) ischemic stroke consecutively admitted to Stroke Unit were included. An unfavorable outcome was defined as a modified Rankin Scale (mRS) score 3. The relationships between serum TTR levels and clinical outcome were analyzed using multivariate analysis. One-year mortality was analyzed by Kaplan–Meier survival curves stratified by mean value of TTR.
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