CLINICAL RESEARCH STUDY
Predictive Parameters of Accelerated Muscle Loss in Men—MINOS Study Alexia Renoud,a René Ecochard, MD, PhD,b François Marchand, MD,c Roland Chapurlat, MD, PhD,a Pawel Szulc, MD, PhDa a Institut National de la Santé et de la Recherche Médicale (INSERM) Unit 1033, University of Lyon, Lyon, France; bDepartment of Biostatistics, University of Lyon, UMR CNRS 5558, Lyon, France; cSociété de Secours Minière de Bourgogne, Montceau les Mines, France.
ABSTRACT BACKGROUND: Aging-related muscle loss is a public health problem. We investigated the association of lifestyle and hormonal factors with a prospectively assessed muscle loss in older men. METHODS: Among 608 home-dwelling men, aged 60-85 (mean 68) years, lifestyle and health status were evaluated through a questionnaire. Appendicular skeletal muscle mass was estimated using dual-energy x-ray absorptiometry and calculated as the sum of lean mass of the 4 limbs. Free testosterone concentration was calculated using concentrations of total testosterone and sex hormone-binding globulin. Longitudinal data were analyzed by hierarchical models. RESULTS: Average muscle loss was 0.63 0.05%/year. The results of our multivariable adjusted analyses showed that muscle loss was higher in men whose leisure physical activity was
Predictive Parameters of Accelerated Muscle Loss in Men—MINOS Study Alexia Renoud,a René Ecochard, MD, PhD,b François Marchand, MD,c Roland Chapurlat, MD, PhD,a Pawel Szulc, MD, PhDa a Institut National de la Santé et de la Recherche Médicale (INSERM) Unit 1033, University of Lyon, Lyon, France; bDepartment of Biostatistics, University of Lyon, UMR CNRS 5558, Lyon, France; cSociété de Secours Minière de Bourgogne, Montceau les Mines, France.
ABSTRACT BACKGROUND: Aging-related muscle loss is a public health problem. We investigated the association of lifestyle and hormonal factors with a prospectively assessed muscle loss in older men. METHODS: Among 608 home-dwelling men, aged 60-85 (mean 68) years, lifestyle and health status were evaluated through a questionnaire. Appendicular skeletal muscle mass was estimated using dual-energy x-ray absorptiometry and calculated as the sum of lean mass of the 4 limbs. Free testosterone concentration was calculated using concentrations of total testosterone and sex hormone-binding globulin. Longitudinal data were analyzed by hierarchical models. RESULTS: Average muscle loss was 0.63 0.05%/year. The results of our multivariable adjusted analyses showed that muscle loss was higher in men whose leisure physical activity was
