Harada et al. BMC Infectious Diseases (2017) 17:638 DOI 10.1186/s12879-017-2745-6
RESEARCH ARTICLE
Open Access
Predictive implications of albumin and C-reactive protein for progression to pneumonia and poor prognosis in Stenotrophomonas maltophilia bacteremia following allogeneic hematopoietic stem cell transplantation Kaito Harada1, Noritaka Sekiya2* , Tatsuya Konishi1, Akihito Nagata1, Yuta Yamada1, Toshiaki Takezaki1, Satoshi Kaito1, Shuhei Kurosawa1, Masahiro Sakaguchi1, Shunichiro Yasuda1, Shugo Sasaki2, Kosuke Yoshioka1, Kyoko Watakabe-Inamoto1, Aiko Igarashi1, Yuho Najima1, Takeshi Hagino1, Hideharu Muto1, Takeshi Kobayashi1, Noriko Doki1, Kazuhiko Kakihana1, Hisashi Sakamaki1 and Kazuteru Ohashi1
Abstract Background: Stenotrophomonas maltophilia (S. maltophilia) bacteremia causes significant morbidity and mortality in immunocompromised hosts. However, incidence and risk factors for mortality in S. maltophilia bacteremia following allogeneic hematopoietic stem cell transplantation (allo-HSCT) remain controversial. The primary aim of this study is to clarify factors associated with poor prognosis of allo-HSCT recipients with S. maltophilia bacteremia. Methods: From January 2005 to December 2014, patients with hematological diseases and S. maltophilia bacteremia at a single transplantation center in Japan were examined for incidence and 90-day mortality. Prognostic factors associated with 90-day mortality among allo-HSCT recipients were analyzed by log-rank test, and significant variables in the univariate analysis were included in the multivariate Cox proportional-hazards regression model. Results: A total of 65 patients, including 47 patients undergoing allo-HSCT, developed S. maltophilia bacteremia. The incidence of S. maltophilia bacteremia was significantly higher in allo-HSCT recipients compared to patients not receiving allo-HSCT (6.53 vs. 0.36 per 100 admissions, respectively; p < 0.01). The overall 90-day mortality in allo-HSCT recipients was 43%. Independent risk factors for 90-day mortality were low serum albumin (
RESEARCH ARTICLE
Open Access
Predictive implications of albumin and C-reactive protein for progression to pneumonia and poor prognosis in Stenotrophomonas maltophilia bacteremia following allogeneic hematopoietic stem cell transplantation Kaito Harada1, Noritaka Sekiya2* , Tatsuya Konishi1, Akihito Nagata1, Yuta Yamada1, Toshiaki Takezaki1, Satoshi Kaito1, Shuhei Kurosawa1, Masahiro Sakaguchi1, Shunichiro Yasuda1, Shugo Sasaki2, Kosuke Yoshioka1, Kyoko Watakabe-Inamoto1, Aiko Igarashi1, Yuho Najima1, Takeshi Hagino1, Hideharu Muto1, Takeshi Kobayashi1, Noriko Doki1, Kazuhiko Kakihana1, Hisashi Sakamaki1 and Kazuteru Ohashi1
Abstract Background: Stenotrophomonas maltophilia (S. maltophilia) bacteremia causes significant morbidity and mortality in immunocompromised hosts. However, incidence and risk factors for mortality in S. maltophilia bacteremia following allogeneic hematopoietic stem cell transplantation (allo-HSCT) remain controversial. The primary aim of this study is to clarify factors associated with poor prognosis of allo-HSCT recipients with S. maltophilia bacteremia. Methods: From January 2005 to December 2014, patients with hematological diseases and S. maltophilia bacteremia at a single transplantation center in Japan were examined for incidence and 90-day mortality. Prognostic factors associated with 90-day mortality among allo-HSCT recipients were analyzed by log-rank test, and significant variables in the univariate analysis were included in the multivariate Cox proportional-hazards regression model. Results: A total of 65 patients, including 47 patients undergoing allo-HSCT, developed S. maltophilia bacteremia. The incidence of S. maltophilia bacteremia was significantly higher in allo-HSCT recipients compared to patients not receiving allo-HSCT (6.53 vs. 0.36 per 100 admissions, respectively; p < 0.01). The overall 90-day mortality in allo-HSCT recipients was 43%. Independent risk factors for 90-day mortality were low serum albumin (
