This article was downloaded by: [Michigan State University] On: 27 February 2015, At: 12:54 Publisher: Routledge Informa Ltd Registered in England and Wales Registered Number: 1072954 Registered office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH, UK
Journal of Clinical and Experimental Neuropsychology Publication details, including instructions for authors and subscription information: http://www.tandfonline.com/loi/ncen20
Posterior brain white matter abnormalities in older adults with probable mild cognitive impairment a
b
b
c
Sarah A. Cooley , Ryan P. Cabeen , David H. Laidlaw , Thomas E. Conturo , d
ae
a
a
Elizabeth M. Lane , Jodi M. Heaps , Jacob D. Bolzenius , Laurie M. Baker , Lauren a
a
E. Salminen , Staci E. Scott & Robert H. Paul
ae
a
Department of Psychology, University of Missouri–Saint Louis, Saint Louis, MO, USA
b
Computer Science Department, Brown University, Providence, RI, USA
c
Click for updates
Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, USA d
Vanderbilt University Medical Center, Nashville, TN, USA
e
Missouri Institute of Mental Health, Saint Louis, MO, USA Published online: 18 Dec 2014.
To cite this article: Sarah A. Cooley, Ryan P. Cabeen, David H. Laidlaw, Thomas E. Conturo, Elizabeth M. Lane, Jodi M. Heaps, Jacob D. Bolzenius, Laurie M. Baker, Lauren E. Salminen, Staci E. Scott & Robert H. Paul (2014): Posterior brain white matter abnormalities in older adults with probable mild cognitive impairment, Journal of Clinical and Experimental Neuropsychology, DOI: 10.1080/13803395.2014.985636 To link to this article: http://dx.doi.org/10.1080/13803395.2014.985636
PLEASE SCROLL DOWN FOR ARTICLE Taylor & Francis makes every effort to ensure the accuracy of all the information (the “Content”) contained in the publications on our platform. However, Taylor & Francis, our agents, and our licensors make no representations or warranties whatsoever as to the accuracy, completeness, or suitability for any purpose of the Content. Any opinions and views expressed in this publication are the opinions and views of the authors, and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content should not be relied upon and should be independently verified with primary sources of information. Taylor and Francis shall not be liable for any losses, actions, claims, proceedings, demands, costs, expenses, damages, and other liabilities whatsoever or howsoever caused arising directly or indirectly in connection with, in relation to or arising out of the use of the Content. This article may be used for research, teaching, and private study purposes. Any substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing, systematic supply, or distribution in any form to anyone is expressly forbidden. Terms & Conditions of access and use can be found at http://www.tandfonline.com/page/terms-and-conditions
Journal of Clinical and Experimental Neuropsychology, 2014 http://dx.doi.org/10.1080/13803395.2014.985636
Posterior brain white matter abnormalities in older adults with probable mild cognitive impairment Sarah A. Cooley1, Ryan P. Cabeen2, David H. Laidlaw2, Thomas E. Conturo3, Elizabeth M. Lane4, Jodi M. Heaps1,5, Jacob D. Bolzenius1, Laurie M. Baker1, Lauren E. Salminen1, Staci E. Scott1, and Robert H. Paul1,5 1
Department of Psychology, University of Missouri–Saint Louis, Saint Louis, MO, USA Computer Science Department, Brown University, Providence, RI, USA 3 Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, USA 4 Vanderbilt University Medical Center, Nashville, TN, USA 5 Missouri Institute of Mental Health, Saint Louis, MO, USA
Downloaded by [Michigan State University] at 12:54 27 February 2015
2
(Received 26 June 2014; accepted 5 November 2014) Objective: Much of the mild cognitive impairment (MCI) neuroimaging literature has exclusively focused on regions associated with Alzheimer’s disease. Little research has examined white matter abnormalities of other brain regions, including those associated with visual processing, despite evidence that other brain abnormalities appear in these regions in early disease stages. Method: Diffusion tensor imaging (DTI) was utilized to examine participants (n = 44) that completed baseline imaging as part of a longitudinal healthy aging study. Participants were divided into two groups based on scores from the Montreal Cognitive Assessment (MoCA), a brief screening tool for MCI. Participants who scored 5 min, past or current substance abuse, a major psychiatric condition (e.g., schizophrenia, untreated anxiety or depression, bipolar disorder), or other medical conditions that could affect cognition including thyroid disease, HIV, epilepsy, multiple sclerosis, or cancer within the last 10 years. All participants were administered the Lawton Instrumental Activities of Daily Living (IADL) to confirm independence in daily functioning (Lawton & Brody, 1969). Montreal Cognitive Assessment The Montreal Cognitive Assessment (MoCA) is a brief test to determine cognitive status and has demonstrated sensitivity to MCI and early AD (Nasreddine et al., 2005). The MoCA consists of 13 tasks that assess several cognitive domains including visuospatial (visuoconstruction), naming, memory, attention, language, abstraction, delayed recall, and orientation. The scores for each task are summed for a total score of 30 points. The education correction was applied for participants with 12 years of education or less that scored fewer than 30 total points. Older adults were subdivided based on the total score on the MoCA. Following conventional cutoffs, individuals with scores
Journal of Clinical and Experimental Neuropsychology Publication details, including instructions for authors and subscription information: http://www.tandfonline.com/loi/ncen20
Posterior brain white matter abnormalities in older adults with probable mild cognitive impairment a
b
b
c
Sarah A. Cooley , Ryan P. Cabeen , David H. Laidlaw , Thomas E. Conturo , d
ae
a
a
Elizabeth M. Lane , Jodi M. Heaps , Jacob D. Bolzenius , Laurie M. Baker , Lauren a
a
E. Salminen , Staci E. Scott & Robert H. Paul
ae
a
Department of Psychology, University of Missouri–Saint Louis, Saint Louis, MO, USA
b
Computer Science Department, Brown University, Providence, RI, USA
c
Click for updates
Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, USA d
Vanderbilt University Medical Center, Nashville, TN, USA
e
Missouri Institute of Mental Health, Saint Louis, MO, USA Published online: 18 Dec 2014.
To cite this article: Sarah A. Cooley, Ryan P. Cabeen, David H. Laidlaw, Thomas E. Conturo, Elizabeth M. Lane, Jodi M. Heaps, Jacob D. Bolzenius, Laurie M. Baker, Lauren E. Salminen, Staci E. Scott & Robert H. Paul (2014): Posterior brain white matter abnormalities in older adults with probable mild cognitive impairment, Journal of Clinical and Experimental Neuropsychology, DOI: 10.1080/13803395.2014.985636 To link to this article: http://dx.doi.org/10.1080/13803395.2014.985636
PLEASE SCROLL DOWN FOR ARTICLE Taylor & Francis makes every effort to ensure the accuracy of all the information (the “Content”) contained in the publications on our platform. However, Taylor & Francis, our agents, and our licensors make no representations or warranties whatsoever as to the accuracy, completeness, or suitability for any purpose of the Content. Any opinions and views expressed in this publication are the opinions and views of the authors, and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content should not be relied upon and should be independently verified with primary sources of information. Taylor and Francis shall not be liable for any losses, actions, claims, proceedings, demands, costs, expenses, damages, and other liabilities whatsoever or howsoever caused arising directly or indirectly in connection with, in relation to or arising out of the use of the Content. This article may be used for research, teaching, and private study purposes. Any substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing, systematic supply, or distribution in any form to anyone is expressly forbidden. Terms & Conditions of access and use can be found at http://www.tandfonline.com/page/terms-and-conditions
Journal of Clinical and Experimental Neuropsychology, 2014 http://dx.doi.org/10.1080/13803395.2014.985636
Posterior brain white matter abnormalities in older adults with probable mild cognitive impairment Sarah A. Cooley1, Ryan P. Cabeen2, David H. Laidlaw2, Thomas E. Conturo3, Elizabeth M. Lane4, Jodi M. Heaps1,5, Jacob D. Bolzenius1, Laurie M. Baker1, Lauren E. Salminen1, Staci E. Scott1, and Robert H. Paul1,5 1
Department of Psychology, University of Missouri–Saint Louis, Saint Louis, MO, USA Computer Science Department, Brown University, Providence, RI, USA 3 Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, USA 4 Vanderbilt University Medical Center, Nashville, TN, USA 5 Missouri Institute of Mental Health, Saint Louis, MO, USA
Downloaded by [Michigan State University] at 12:54 27 February 2015
2
(Received 26 June 2014; accepted 5 November 2014) Objective: Much of the mild cognitive impairment (MCI) neuroimaging literature has exclusively focused on regions associated with Alzheimer’s disease. Little research has examined white matter abnormalities of other brain regions, including those associated with visual processing, despite evidence that other brain abnormalities appear in these regions in early disease stages. Method: Diffusion tensor imaging (DTI) was utilized to examine participants (n = 44) that completed baseline imaging as part of a longitudinal healthy aging study. Participants were divided into two groups based on scores from the Montreal Cognitive Assessment (MoCA), a brief screening tool for MCI. Participants who scored 5 min, past or current substance abuse, a major psychiatric condition (e.g., schizophrenia, untreated anxiety or depression, bipolar disorder), or other medical conditions that could affect cognition including thyroid disease, HIV, epilepsy, multiple sclerosis, or cancer within the last 10 years. All participants were administered the Lawton Instrumental Activities of Daily Living (IADL) to confirm independence in daily functioning (Lawton & Brody, 1969). Montreal Cognitive Assessment The Montreal Cognitive Assessment (MoCA) is a brief test to determine cognitive status and has demonstrated sensitivity to MCI and early AD (Nasreddine et al., 2005). The MoCA consists of 13 tasks that assess several cognitive domains including visuospatial (visuoconstruction), naming, memory, attention, language, abstraction, delayed recall, and orientation. The scores for each task are summed for a total score of 30 points. The education correction was applied for participants with 12 years of education or less that scored fewer than 30 total points. Older adults were subdivided based on the total score on the MoCA. Following conventional cutoffs, individuals with scores
