1187
Report on the 8th International histocompatibility testing workshop, 1980: 285-86. 19. Vento S, McFarlane BM, McSorley CG, et al. Liver autoreactivity in acute virus A, B and non-A, non-B hepatitis. J Clin Lab Immunol 1988; ed.
25: 1-7. 20. Vallbracht A, Gabriel P, Maier K, et al. Cell-mediated cytotoxicity in hepatitis A virus infection. Hepatology 1986; 6: 1308-14. 21. Allison AC, Denman AM, Barnes RD. Cooperating and controlling functions of thymus-derived lymphocytes in relation to autoimmunity. Lancet 1971; ii: 135-40. 22. Vento S, McFarlane BM, Garofano T, et al. Serial study of liver-directed
23.
24.
25. 26.
autoantibodies and autoreactive T lymphocytes in acute viral hepatitis B. J Autoimmunity 1988; 1: 299-307. Mieli-Vergani G, Vergani D, Jenkins PJ, et al. Lymphocyte cytotoxicity to autologous hepatocytes in HBsAg-negative chronic active hepatitis. Clin Exp Immunol 1979; 38: 16-25. Robertson DAF, Zhang SL, Guy EC, Wright R. Persistent measles virus genome in autoimmune chronic active hepatitis. Lancet 1987; ii: 9-11. Esteban JI, Esteban R, Viladomiu L, et al. Hepatitis C virus antibodies among risk groups in Spain. Lancet 1989; ii: 294-96. Mieli-Vergani G, Sutherland S, Mowat AP. Measles and autoimmune chronic active hepatitis. Lancet 1989; ii: 688.
Possible association between mutant frequency in peripheral lymphocytes and domestic radon concentrations
investigate whether previously found geographical correlations between leukaemia
To
incidence and exposure to radon are reflected in a detectable mutagenic effect on individuals, the frequency of mutations in the hypoxanthine guanine phosphoribosyl transferase gene (hprt) in peripheral blood T lymphocytes was measured in subjects with known domestic radon concentrations. These concentrations were measured in December, 1989, in houses in Street, Somerset, UK, by passive alpha-track radon detectors. 20 non-smoking subjects aged 36-55 years were selected from the patient list at the local health centre on the basis of the radon concentrations in their homes—the range selected varied by a factor of ten. Blood samples for preparation of T lymphocytes were taken in July, 1990. There was a significant association between the log mutant frequency and radon concentration (t= 3·47, p
Report on the 8th International histocompatibility testing workshop, 1980: 285-86. 19. Vento S, McFarlane BM, McSorley CG, et al. Liver autoreactivity in acute virus A, B and non-A, non-B hepatitis. J Clin Lab Immunol 1988; ed.
25: 1-7. 20. Vallbracht A, Gabriel P, Maier K, et al. Cell-mediated cytotoxicity in hepatitis A virus infection. Hepatology 1986; 6: 1308-14. 21. Allison AC, Denman AM, Barnes RD. Cooperating and controlling functions of thymus-derived lymphocytes in relation to autoimmunity. Lancet 1971; ii: 135-40. 22. Vento S, McFarlane BM, Garofano T, et al. Serial study of liver-directed
23.
24.
25. 26.
autoantibodies and autoreactive T lymphocytes in acute viral hepatitis B. J Autoimmunity 1988; 1: 299-307. Mieli-Vergani G, Vergani D, Jenkins PJ, et al. Lymphocyte cytotoxicity to autologous hepatocytes in HBsAg-negative chronic active hepatitis. Clin Exp Immunol 1979; 38: 16-25. Robertson DAF, Zhang SL, Guy EC, Wright R. Persistent measles virus genome in autoimmune chronic active hepatitis. Lancet 1987; ii: 9-11. Esteban JI, Esteban R, Viladomiu L, et al. Hepatitis C virus antibodies among risk groups in Spain. Lancet 1989; ii: 294-96. Mieli-Vergani G, Sutherland S, Mowat AP. Measles and autoimmune chronic active hepatitis. Lancet 1989; ii: 688.
Possible association between mutant frequency in peripheral lymphocytes and domestic radon concentrations
investigate whether previously found geographical correlations between leukaemia
To
incidence and exposure to radon are reflected in a detectable mutagenic effect on individuals, the frequency of mutations in the hypoxanthine guanine phosphoribosyl transferase gene (hprt) in peripheral blood T lymphocytes was measured in subjects with known domestic radon concentrations. These concentrations were measured in December, 1989, in houses in Street, Somerset, UK, by passive alpha-track radon detectors. 20 non-smoking subjects aged 36-55 years were selected from the patient list at the local health centre on the basis of the radon concentrations in their homes—the range selected varied by a factor of ten. Blood samples for preparation of T lymphocytes were taken in July, 1990. There was a significant association between the log mutant frequency and radon concentration (t= 3·47, p
