Antimicrobial Reviews

Population Pharmacokinetics of Intravenous Acyclovir in Preterm and Term Infants Mario R. Sampson, PharmD,*† Barry T. Bloom, MD,‡ Robert W. Lenfestey, MD, MHS,* Barrie Harper, BSMT (ASCP),* Angela D. Kashuba, PharmD,† Ravinder Anand, PhD,§ Daniel K. Benjamin Jr., MD, PhD, MPH,* Edmund Capparelli, PharmD,*¶ Michael Cohen-Wolkowiez, MD, PhD,* and P. Brian Smith, MD, MPH, MHS,* on behalf of the Best Pharmaceuticals for Children Act–Pediatric Trials Network

Background: Acyclovir is used to treat herpes infections in preterm and term infants; however, the influence of maturation on drug disposition and dosing requirements is poorly characterized in this population. Methods: We administered intravenous acyclovir to preterm and term infants

Population pharmacokinetics of intravenous acyclovir in preterm and term infants.

Acyclovir is used to treat herpes infections in preterm and term infants; however, the influence of maturation on drug disposition and dosing requirem...
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