Original Article doi: 10.1111/joim.12270
Pneumonia and the incidence of cancer: a Danish nationwide cohort study K. K. Søgaard1, D. K. Farkas1, L. Pedersen1, N. S. Weiss2, R. W. Thomsen1 & H. T. Sørensen1 From the 1Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; and 2Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA
Abstract. Søgaard KK, Farkas DK, Pedersen L, Weiss NS, Thomsen RW, Sørensen HT (Aarhus University Hospital, Aarhus, Denmark; University of Washington, Seattle, WA, USA). Pneumonia and the incidence of cancer: a Danish nationwide cohort study. J Intern Med 2015; 277: 429–438. Objectives. To examine the risk of a subsequent pulmonary or extra-pulmonary cancer diagnosis following a first-time hospital-based diagnosis of pneumonia. Design. Population-based cohort study using Danish medical registries. Setting. All hospitals in Denmark. Subjects. A total of 342 609 patients with a first-time hospital-based (inpatient, emergency room or outpatient clinic) diagnosis of pneumonia between 1995 and 2011. Main outcome measures. We quantified the excess risk of various cancers amongst pneumonia patients compared to the expected risk in the general population, using relative [standardised incidence ratios (SIRs)] and absolute risk calculations. Follow-up started 1 month after a
Introduction Pneumonia, which is a frequent cause of hospitalisation, may be associated with an increased risk of a cancer diagnosis, through one or more possible mechanisms. First, a primary tumour or metastasis may be misdiagnosed initially as pneumonia [1, 2]. Secondly, the compromised immune function that is observed with cancer, in addition to a direct tumour effect on infection barriers (such as local invasion of the lungs), may account for some of the association between pneumonia and a cancer diagnosis [3, 4]. Thirdly, pneumonia might initiate a chronic local inflammatory process, which may
hospital-based diagnosis of pneumonia and ended on 31 December 2011. Results. A total of 28 496 cancers were observed, compared with 21 625 expected, amongst 342 609 pneumonia patients followed for a median of 4.2 years. The absolute risk of a cancer diagnosis 1 to
Pneumonia and the incidence of cancer: a Danish nationwide cohort study K. K. Søgaard1, D. K. Farkas1, L. Pedersen1, N. S. Weiss2, R. W. Thomsen1 & H. T. Sørensen1 From the 1Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark; and 2Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA, USA
Abstract. Søgaard KK, Farkas DK, Pedersen L, Weiss NS, Thomsen RW, Sørensen HT (Aarhus University Hospital, Aarhus, Denmark; University of Washington, Seattle, WA, USA). Pneumonia and the incidence of cancer: a Danish nationwide cohort study. J Intern Med 2015; 277: 429–438. Objectives. To examine the risk of a subsequent pulmonary or extra-pulmonary cancer diagnosis following a first-time hospital-based diagnosis of pneumonia. Design. Population-based cohort study using Danish medical registries. Setting. All hospitals in Denmark. Subjects. A total of 342 609 patients with a first-time hospital-based (inpatient, emergency room or outpatient clinic) diagnosis of pneumonia between 1995 and 2011. Main outcome measures. We quantified the excess risk of various cancers amongst pneumonia patients compared to the expected risk in the general population, using relative [standardised incidence ratios (SIRs)] and absolute risk calculations. Follow-up started 1 month after a
Introduction Pneumonia, which is a frequent cause of hospitalisation, may be associated with an increased risk of a cancer diagnosis, through one or more possible mechanisms. First, a primary tumour or metastasis may be misdiagnosed initially as pneumonia [1, 2]. Secondly, the compromised immune function that is observed with cancer, in addition to a direct tumour effect on infection barriers (such as local invasion of the lungs), may account for some of the association between pneumonia and a cancer diagnosis [3, 4]. Thirdly, pneumonia might initiate a chronic local inflammatory process, which may
hospital-based diagnosis of pneumonia and ended on 31 December 2011. Results. A total of 28 496 cancers were observed, compared with 21 625 expected, amongst 342 609 pneumonia patients followed for a median of 4.2 years. The absolute risk of a cancer diagnosis 1 to
